SARS CoV-2 (COVID-19) Coronavirus cases are confirmed throughout the world and millions of people are being put into quarantine. A better understanding of the effective parameters in infection spreading can bring about a logical measurement toward COVID-19. The effect of climatic factors on spreading of COVID-19 can play an important role in the new Coronavirus outbreak. In this study, the main parameters, including the number of infected people with COVID-19, population density, intra-provincial movement, and infection days to end of the study period, average temperature, average precipitation, humidity, wind speed, and average solar radiation investigated to understand how can these parameters effects on COVID-19 spreading in Iran?The Partial correlation coefficient (PCC) and Sobol'-Jansen methods are used for analyzing the effect and correlation of variables with the COVID-19 spreading rate. The result of sensitivity analysis shows that the population density, intra-provincial movement have a direct relationship with the infection outbreak. Conversely, areas with low values of wind speed, humidity, and solar radiation exposure to a high rate of infection that support the virus's survival. The provinces such as Tehran, Mazandaran, Alborz, Gilan, and Qom are more susceptible to infection because of high population density, intra-provincial movements and high humidity rate in comparison with Southern provinces. Journal Pre-proof J o u r n a l P r e -p r o o f speed, and humidity. Consequently, based on the geographical maps, the average rate of disease spread in humid provinces is higher than in other areas of Iran, however in arid areas humidity has a reverse relationship with the disease infection rate; the central provinces of Iran are approximately higher than in non-central and southern regions. Journal Pre-proof J o u r n a l P r e -p r o o f 9The effective parameters in the COVID-19 outbreak show that Tehran, Mazandaran, Alborz, Gilan, and Qom people are more exposed to virus spreading because of the high population. Moreover, in provinces as a destination of intra-provincial movements, Tehran, Isfahan, Khorasan Razavi, and Fars population are more susceptible to the COVID-19 virus. The Gilan and Mazandaran provinces have wet weather; therefore, the high infection rate; besides, the wind speed is low in these cities plus Tehran and Gorgan. The southern region of Iran includes Sistan and Baluchestan, Kerman, Hormozgan, and Boushehr have lower infection rate because of high solar radiation. Based on literature results the coronavirus is created because of dramatic solar activity when in a period of years (~10) appearance of two peaks in sunspots creates coronavirus. Therefore, we should expect these types of pandemics once every 10 years. Future studies should pay more attention to provide results based on experimental and observational studies and considering how the factors can affect COVID-19 spreading.Also, long term studies of world climates can anticipate other possible pandemics.