High Survival Rate in Childhood Non-Hodgkin Lymphoma without CNS Involvement: Results of BFM 95 Study in Kuwait

Abstract

Non-Hodgkin lymphomas (NHL) in children are the second most common malignant tumors in Kuwait. Until 1995 the patients (pts) received institutional protocols. From October 1995 to September 2000 21 children with NHL were treated. Five children were treated by NHL BFM 90 protocol, 7 pts received NHL BFM 95 scheme, and 9 children underwent therapy abroad or according to different types of protocols. The results of a retrospective analysis of NHL BFM 95 protocol in Kuwait are reported. Seven patients diagnosed with NHL--group B: 3 children with Burkitt lymphoma (B-cell NHL) and group A: 4 children with lymphoblastic lymphoma (T-cell NHL)--were treated from October 1995 to September 2000 in the Kuwait Cancer Control Centre according to NHL BFM 95 protocol. Group B consisted of 2 girls and 1 boy; median age at diagnosis was 4 years 8 months, 2 pts classified as stage II and 1 pt as stage III. All patients were assigned to risk group R2. Median follow-up is 2 years 8 months. Group A included 1 girl and 3 boys; median age at diagnosis was 5 years 8 months, 1 pt classified as stage III and 3 pts as stage IV. All patients were assigned to IR group. Median follow-up is 3 years 6 months. In group B all 3 pts are in 1st CR; in group A 3 pts are in 1st CR and 1 pt having Li-Fraumani syndrome died after the 3rd relapse of disease during therapy. In both groups there was no toxic death, myelotoxicity WHO grade III-IV, hepatotoxicity WHO grade II-III. Treatment results of NHL BFM 95 study in our small group of patients are very optimistic. Six patients are in 1st CR and one died due to progression of disease. Despite the small group of patients, the results suggest that NHL BFM 95 protocol is highly effective and safe with regular supportive care.

Clinicopathological Features of Extranodal Lymphomas: Kuwait Experience

“…Elsewhere, BL was rare, though the incidence was somewhat higher in Spain and North Africa. In Kuwait, NHL in children is the second most common malignant tumor [24]. We could demonstrate that the overwhelming majority (77.2%) was BL followed by DLBCL.…”

Genomic signatures in pediatric advanced stage Burkitt lymphoma/leukemia in a Chinese population detected by next generation sequencing

“…During this period, one patient classified into stage II was admitted, but his parents refused this study. The patients received chemotherapy in accordance with modified non-Hodgkin Lymphoma 1995, Berlin-Frankfurt-Münster, (BFM-95) protocol [8,9]. Intrathecal injections (iT) were administered as the protocol required and cranial radiotherapy was carried out for the patients with central nervous system (CNS) involvement.…”

Genomic signatures in pediatric advanced stage Burkitt lymphoma/leukemia in a Chinese population detected by next generation sequencing

“…Patients who were ≥18 yr at diagnosis or diagnosed with Burkitt-like lymphoma with 11q aberration, secondary lymphoma, or had human immunodeficiency virus infection were excluded; patients who were classi ed into local stages (stage I or stage II) or had received chemotherapy before hospitalization, were also excluded from the study. The patients received chemotherapy in accordance with the modi ed non-Hodgkin Lymphoma 1995, Berlin-Frankfurt-Münster, (BFM-95) protocol [8,9]. Intrathecal injections (iT) were administered as the protocol required and cranial radiotherapy was carried out for the patients with central nervous system (CNS) involvement.…”