High success rate with new modified endoscopic treatment for high-grade VUR: A pilot study with preliminary report

Endoscopic correction of vesicoureteral reflux in children using polyacrylate-polyalcohol copolymer (Vantris): 5-years of prospective follow-up

“…A high level of reflux resolution using PPC is noted. The results showed that reflux was corrected in about 90% of cases after single PPC injection, with no recurrence during prospective follow-up [ 5 , 13 , 14 , 15 , 16 , 18 , 19 ].…”

“…PPC is used successfully to treat primary reflux and also for complex cases [ 9 , 10 , 13 , 14 , 16 , 18 , 19 ]. The use of PPC to correct grades IV and V is also very efficient with an overall success rate achieved of over 80% [ 8 , 11 , 13 , 15 , 17 ].…”

The Results of Endoscopic Treatment of Grade IV and V Persistent Vesiocoureteral Reflux in Children Using PolyacrylatePolyalcohol Copolymer (Vantris)

“…In 2010 Hunziker et al presenting 8-years experience with endoscopic correction of primary grade V reflux using Dx/HA (Deflux ®) (56 children, 63 RRUs) noted 52.4% success rate after single injection and downgrading to grade I in 11.1% whereas 30.2% of ureters required second and 6.3 % third injection to resolve VUR [9]. Recently published results with PPC (Vantris ®) to treat grade IV and V VUR showed significantly higher success rate as compared with Dx/HA (Deflux ®): 80-83,3 % resolution rate after single injection [10,11] or even 91.8% [12]. In 2013 we published our preliminary results: 13 RRUs grade IV VUR and 19 RRUs grade V with reflux resolution rate in 84.6 % and 89.5% of RRUs respectively after first injection and in 100% after repeated procedure [18].…”

“…A limited number of reports regarding results and efficacy of endoscopic management of high grade reflux is still available. Various bulking agents were used for this purpose: polytetrafluoroethylene (PTFE) before 2000, dextranomer/hyaluronic acid copolymer (Dx/HA, Deflux ®) since 2000 and recently polyacrylate-polyalcoholcopolymer (PPC, Vantris ®) [4,5,6,7,8,9,10,11,12]. PPC (Vantris ®) a synthetic, non-absorbable tissueaugmenting substance was introduced into clinical practice in 2010 [13] and is currently used in some centers Around the world [14,15,16,17,18,19,20].The aim of the present study was to evaluate the efficacy of PPC injection to correct reflux grade IV and V in children.…”

Modified unilateral periureteral injection technique in the treatment of patients with high-grade vesicoureteral reflux: A study of primary findings

“…Inevitably, ureteral reimplantation has become the standard therapy for high-grade VUR [ 7 ]. To overcome the shortcomings, we introduced a new modified endoscopic treatment, called bilateral periurethral injection technique (PIT) in a previous study and reported the primary outcome that had an acceptable success rate in patients with high-grade VUR [ 8 ]. In the bilateral PIT, injection is performed in the subureteral orifice at 5- and 7-o'clock positions.…”