High-strength, ultra-thin and fiber-reinforced pHEMA artificial skin

Young, C.D.; Wu, Jing-Ran; Tsou, Tai Li

doi:10.1016/s0142-9612(98)00083-0

Cited by 111 publications

(69 citation statements)

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“…Among different hydrogel systems being covalently crosslinked, Poly(2-hydroxyethyl methacrylate) (PHEMA) has received considerable attention as a biocompatible hydrogel with tunable mechanical properties (Voldrich et al, 1975;Lou et al, 2004;Young et al, 1998;Traian, 2001;Moghadam et al, 2014). HEMA monomers have a hydrophilic nature.…”

Section: Introductionmentioning

confidence: 99%

Improving hydrogels׳ toughness by increasing the dissipative properties of their network

Moghadam

Pioletti

2015

Journal of the Mechanical Behavior of Biomedical Materials

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a b s t r a c tThe weak mechanical performance and fragility of hydrogels limit their application as biomaterials for load bearing applications. The origin of this weakness has been explained by the low resistance to chains breakage composing the hydrogel and to the cracks propagation in the hydrogel submitted to loading conditions. These low resistance and crack propagation were in turn related to an insufficient energy dissipation mechanism in the hydrogel structure. The goal of this study is to evaluate the dissipation mechanism in covalently bonded hydrogels so that tougher hydrogels can be developed while keeping for the hydrogel a relatively high mechanical stiffness. By varying parameters such as crosslinker type or concentration as well as water ratio, the dissipative properties of HEMAbased hydrogels were investigated at large deformations. Different mechanisms such as special friction-like phenomena, nanoporosity, and hydrophobicity were proposed to explain the dissipative behavior of the tested hydrogels. Based on this analysis, it was possible to develop hydrogels with increased toughness properties.

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Section: Introductionmentioning

confidence: 99%

Improving hydrogels׳ toughness by increasing the dissipative properties of their network

Moghadam

Pioletti

2015

Journal of the Mechanical Behavior of Biomedical Materials

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“…In such case, original hydrogel usually acts as micro-or nanofibres to achieve the reinforcement of the composite hydrogel, by constructing its internal network structure similar to the reinforced concrete. The nanofibres can be short fibres like woven 11 , polymer fibrils formed by polyvinyl alcohol 12 , or bacterial cellulose 13 . Such fibre-reinforced hydrogels can exhibit high strength, high tolerance to tensile strain, and good fracture toughness.…”

Section: Introductionmentioning

confidence: 99%

Microstructural and mechanical characteristics of PHEMA-based nanofibre-reinforced hydrogel under compression

Zhao

Shi

Chen

et al. 2015

Composites Part B: Engineering

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Natural network-structured hydrogels (e.g. bacterial cellulose (BC)) can be synthesised with specific artificial hydrogels (e.g. poly(2-hydroxyethyl methacrylate)(PHEMA)) to form a tougher and stronger nanofibre-reinforced composite hydrogel, which possesses micro-and nano-porous structure.These synthetic hydrogels exhibit a number of advantages for biomedical applications, such as good biocompatibility and better permeability for molecules to pass through. In this paper, the mechanical properties of this nanofibre-reinforced hydrogel containing BC and PHEMA have been characterised in terms of their tangent modulus and fracture stress/strain by uniaxial compressive testing. Numerical simulations based on Mooney-Rivlin hyperelastic theory are also conducted to understand the internal stress distribution and possible failure of the nanofibre-reinforced hydrogel under compression. By comparing the mechanical characteristics of BC, PHEMA, and PHEMA-based nanofibre reinforced hydrogel (BC-PHEMA) under the compression, it is possible to develop a suitable scaffold for tissue engineering on the basis of fundamental understanding of mechanical and fracture behaviours of nanofibre-reinforced hydrogels.

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“…In such kind of materials, the mechanical properties are presumed to be improved and the biocompatible characteristics of the acrylic polymer should remain the same. Thus, acrylic resin polymers have been reinforced with glass fibers for dental applications [30], and acrylic hydrogels such as poly(2-hydroxyethyl methacrylate), which is one of the most popular biomaterials, have been manufactured by adding various kinds of weaved and knitted fabrics and fibers, in order to improve overall qualities of the poly(2-hydroxethyl methacrylate) (PHEMA)-based artificial skin for advanced wound dressing usage [31]. However, in the recent decades, natural fibers as an alternative reinforcement in polymer composites have attracted the attention of many research groups due to their advantages over conventional glass and carbon fibers [32].…”

Section: Compositesmentioning

confidence: 99%

Latest Improvements of Acrylic-Based Polymer Properties for Biomedical Applications

Serrano‐Aroca¹

2017

Acrylic Polymers in Healthcare

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Acrylic-based polymers have many currently important biomedical applications such as contact lenses, corneal prosthesis, bone cements, tissue engineering, etc. due to their excellent biocompatibility and suitable performance in mechanical properties, among many other applications. Many of these biomaterials have been approved by the US Food and Drug Administration (FDA) for various applications. However, the potential uses of these polymeric materials in the biomedical industry could be increased exponentially if some of their acrylic properties (mechanical strength, electrical and/or thermal properties, water sorption and diffusion, biological interactions, antibacterial activity, porosity, etc.) are enhanced. Thus, acrylics have been fabricated as multicomponent polymeric systems in the form of interpenetrated polymer networks or combined with other advanced materials such as fibers, nanofibers, graphene and its derivatives and/or many other kinds of nanoparticles to form composite or nanocomposite materials, which are expected to exhibit superior properties. Besides, in regenerative medicine, acrylic scaffolds need to be designed with the required extent and morphology of pores by sophisticated techniques. Even though the great advances have been achieved so far, much research has to be carried out still in order to find new strategies to improve the above-mentioned properties.

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High-strength, ultra-thin and fiber-reinforced pHEMA artificial skin

Cited by 111 publications

References 0 publications

Improving hydrogels׳ toughness by increasing the dissipative properties of their network

Improving hydrogels׳ toughness by increasing the dissipative properties of their network

Microstructural and mechanical characteristics of PHEMA-based nanofibre-reinforced hydrogel under compression

Latest Improvements of Acrylic-Based Polymer Properties for Biomedical Applications

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