High-strength, porous additively manufactured implants with optimized mechanical osseointegration

Kelly, Cambre; Wang, Tian; Crowley, J. D.; Wills, Daniel; Pelletier, Matthew H.; Westrick, Edward; Adams, Samuel B.; Gall, Ken; Walsh, William R.

doi:10.1016/j.biomaterials.2021.121206

Cited by 80 publications

(44 citation statements)

References 47 publications

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“…The above results show that the combination of TO design and a porous structure plays an important role in realizing the osseointegration of a prosthesis. The surface of a porous structure can reduce the elastic modulus of the prosthesis, and with an increase in porosity, the pore volume of bone growth also increases so as to improve the performance of bone integration ( Kelly et al, 2021 ). Shah et al (2016) also confirmed that metal implants with an interconnected pore structure have the potential to promote bone growth, and they may also reduce the stiffness mismatch between implant and bone so as to eliminate the stress-shielding effect.…”

Section: Discussionmentioning

confidence: 99%

Improving the Stability of a Hemipelvic Prosthesis Based on Bone Mineral Density Screw Channel and Prosthesis Optimization Design

Zhou

Xue²,

Wang³

et al. 2022

Front. Bioeng. Biotechnol.

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In pelvic reconstruction surgery, the hemipelvic prosthesis can cause significant changes in stress distribution due to its high stiffness, and its solid structure is not suitable for osseointegration. The purpose of this study was to identify a novel bone mineral density screw channel and design the structure of the prosthesis so as to improve the distribution of stress, promote bone growth, and enhance the biomechanical properties of the prosthesis. The mechanical characteristics of bone mineral density screw and traditional screw were compared by finite element analysis method, and redesigned by topology optimization. The direction of the newly proposed screw channel was the posterolateral entrance of the auricular surface, ending at the contralateral sacral cape. Compared to the original group, the maximum stress of the optimized prosthesis was decreased by 24.39%, the maximum stress of the sacrum in the optimized group was decreased by 27.23%, and the average strain energy density of the sacrum in the optimized group was increased by 8.43%. On the surface of screw and connecting plate, the area with micromotion more than 28 μm is reduced by 12.17%. On the screw surface, the area with micromotion more than 28 μm is reduced by 22.9%. The newly determined screw channel and optimized prosthesis design can effectively improve the biomechanical properties of a prosthesis and the microenvironment of osseointegration. This method can provide a reference for the fixation of prostheses in clinical pelvic reconstruction.

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Section: Discussionmentioning

confidence: 99%

Improving the Stability of a Hemipelvic Prosthesis Based on Bone Mineral Density Screw Channel and Prosthesis Optimization Design

Zhou

Xue²,

Wang³

et al. 2022

Front. Bioeng. Biotechnol.

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“…Cell adhesion is an important factor affecting the ability of bone integration ( Zhao et al, 2013 ; Taale et al, 2018 ; Kelly et al, 2021 ). Therefore, we further studied the adhesion of MSCs to the bone surface prepared by the two cutting tools.…”

Section: Discussionmentioning

confidence: 99%

Ultra-Pulsed CO2 Laser Osteotomy: A New Method for the Bone Preparation of Total Knee Arthroplasty

Ran

Lin

et al. 2022

Front. Bioeng. Biotechnol.

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Cementless total knee arthroplasty (TKA) can achieve long-term biological fixation, but its application is limited by the risk of early aseptic loosening. One of the important reasons for early aseptic loosening is that mechanical osteotomy tools cannot achieve ideal bone preparation because of poor accuracy and serious bone tissue damage produced by them. Therefore, we designed an ultra-pulsed CO2 laser osteotomy system to solve these problems. To reveal the safety at the tissue and cell levels of the ultra-pulsed CO2 laser osteotomy system, a series of experiments on distal femur osteotomy in animals were performed. Then, the bone surface characteristics were analyzed through scanning electron microscopy, and the bone thermal and mechanical damage was evaluated via histological analysis. Finally, mesenchymal stem cells (MSCs) were inoculated on the bone surfaces prepared by the two osteotomy tools, and the effect of cell adhesion was analyzed through a confocal laser scanning microscope (CLSM). We successfully achieved TKA bone preparation of animal knees with the ultra-pulsed CO2 laser osteotomy system. Moreover, the biological evaluation results indicated that compared with the traditional mechanical saw, the laser can preserve the natural bone structure and cause no thermal damage to the bone. In addition, CLSM examination results showed that the laser-cut bone surface was more conducive to cell adhesion and infiltration than the bone surface cut by a mechanical saw. Overall, these results indicate that ultra-pulsed CO2 laser can achieve non-invasive bone cutting, which can be a new option for TKA bone preparation and has the potential to lead in the future.

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“…The purpose of the present study is to investigate the effect of introducing TPMS lattices with varying porosity on the electrochemical performance of 60% and 80% porous gyroid lattices created by laser powder bed fusion (LPBF), and solid control samples produced in the same manner. The 60% and 80% gyroid test groups that were selected as a study by Kelly et al revealed that 60% samples experienced higher rates of osseointegration and increased mechanical fixation strength in a bicortical defect model, whilst samples exceeding 80% porosity were found to show diminishing bone ingrowth and strength [ 43 ]. Key identifiers from polarisation testing and qualitative analysis allowed for both the severity and susceptibility of samples to be compared, with an initial hypothesis being that an increase in porosity will increase both the susceptibility and severity of corrosion encountered.…”

Section: Introductionmentioning

confidence: 99%

Corrosion Resistance of 3D Printed Ti6Al4V Gyroid Lattices with Varying Porosity

et al. 2022

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Corrosion of medical implants is a possible failure mode via induced local inflammatory effects, systemic deposition and corrosion related mechanical failure. Cyclic potentiodynamic polarisation (CPP) testing was utilized to evaluate the effect of increased porosity (60% and 80%) and decreased wall thickness in gyroid lattice structures on the electrochemical behaviour of LPBF Ti6Al4V structures. The use of CPP allowed for the landmarks of breakdown potential, resting potential and vertex potential to be analysed, as well as facilitating the construction of Tafel plots and qualitative Goldberg analysis. The results indicated that 60% gyroid samples were most susceptible to the onset of pitting corrosion when compared to 80% gyroid and solid samples. This was shown through decreased breakdown and vertex potentials and were found to correlate to increased lattice surface area to void volume ratio. Tafel plots indicated that despite the earlier onset of pitting corrosion, both gyroid test groups displayed lower rates of corrosion per year, indicating a lower severity of corrosion. This study highlighted inherent tradeoffs between lattice optimisation and corrosion behaviour with a potential parabolic link between void volume, surface area and corrosion being identified. This potential link is supported by 60% gyroid samples having the lowest breakdown potentials, but investigation into other porosity ranges is suggested to support the hypothesis. All 3D printed materials studied here showed breakdown potentials higher than ASTM F2129′s suggestion of 800 mV for evaluation within the physiological environment, indicating that under static conditions pitting and crevice corrosion should not initiate within the body.

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High-strength, porous additively manufactured implants with optimized mechanical osseointegration

Cited by 80 publications

References 47 publications

Improving the Stability of a Hemipelvic Prosthesis Based on Bone Mineral Density Screw Channel and Prosthesis Optimization Design

Improving the Stability of a Hemipelvic Prosthesis Based on Bone Mineral Density Screw Channel and Prosthesis Optimization Design

Ultra-Pulsed CO2 Laser Osteotomy: A New Method for the Bone Preparation of Total Knee Arthroplasty

Corrosion Resistance of 3D Printed Ti6Al4V Gyroid Lattices with Varying Porosity

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