High strength gelatin-based nanocomposites reinforced by surface-deacetylated chitin nanofiber networks

Chen, Chuchu; Wang, Yiren; Yang, Yini; Pan, Mingzhu; Ye, Ting

doi:10.1016/j.carbpol.2018.04.095

Cited by 39 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, specific modifications should be involved for reinforcing G5 without affecting its degradability because the weak mechanical strength and relative low gelation temperature of G5 can dramatically jeopardize printability, resulting in the poor structural control of the printed scaffolds. Chen et al demonstrated that the mechanical strength of gelatin hydrogels can be reinforced 2.7-fold by introducing reinforcing fillers composed of deacetylated chitin nanofibers [46], which could be considered as an effective route to optimize the printability and enzymatic degradability of gelatin-based bioinks.…”

Section: Hdf-laden Scaffold Fabricationmentioning

confidence: 99%

Effects of Gelatin Methacrylate Bio-ink Concentration on Mechano-Physical Properties and Human Dermal Fibroblast Behavior

Shie

Lee

et al. 2020

Polymers

View full text Add to dashboard Cite

Gelatin-methacryloyl (GelMa) is a very versatile biomaterial widely used in various biomedical applications. The addition of methacryloyl makes it possible to have hydrogels with varying mechanical properties due to its photocuring characteristics. In addition, gelatin is obtained and derived from natural material; thus, it retains various cell-friendly motifs, such as arginine-glycine-aspartic acid, which then provides implanted cells with a friendly environment for proliferation and differentiation. In this study, we fabricated human dermal fibroblast cell (hDF)-laden photocurable GelMa hydrogels with varying physical properties (5%, 10%, and 15%) and assessed them for cellular responses and behavior, including cell spreading, proliferation, and the degree of extracellular matrix remodeling. Under similar photocuring conditions, lower concentrations of GelMa hydrogels had lower mechanical properties than higher concentrations. Furthermore, other properties, such as swelling and degradation, were compared in this study. In addition, our findings revealed that there were increased remodeling and proliferation markers in the 5% GelMa group, which had lower mechanical properties. However, it was important to note that cellular viabilities were not affected by the stiffness of the hydrogels. With this result in mind, we attempted to fabricate 5–15% GelMa scaffolds (20 × 20 × 3 mm3) to assess their feasibility for use in skin regeneration applications. The results showed that both 10% and 15% GelMa scaffolds could be fabricated easily at room temperature by adjusting several parameters, such as printing speed and extrusion pressure. However, since the sol-gel temperature of 5% GelMa was noted to be lower than its counterparts, 5% GelMa scaffolds had to be printed at low temperatures. In conclusion, GelMa once again was shown to be an ideal biomaterial for various tissue engineering applications due to its versatile mechanical and biological properties. This study showed the feasibility of GelMa in skin tissue engineering and its potential as an alternative for skin transplants.

show abstract

Section: Hdf-laden Scaffold Fabricationmentioning

confidence: 99%

Effects of Gelatin Methacrylate Bio-ink Concentration on Mechano-Physical Properties and Human Dermal Fibroblast Behavior

Shie

Lee

et al. 2020

Polymers

View full text Add to dashboard Cite

show abstract

“…Two significant peaks at approximately 3358 and 3290 cm −1 were attributed to O−H and N−H stretching vibrations of functional groups engaged in intramolecular hydrogen bonding between chitosan molecules. 30 The hydroxy (−OH), acetylamino (−CH 3 CONH 2 ), and amino (−NH 2 ) side groups located along the a-axis could induce numerous intra-and intermolecular hydrogen bonds, which made it difficult to peel off the molecular chains from each other.…”

Section: Resultsmentioning

confidence: 99%

Strong, Water-Resistant, and Ionic Conductive All-Chitosan Film with a Self-Locking Structure

Wang

Wan

et al. 2022

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Renewable and biodegradable natural polymeric materials are attractive candidates for replacing nonbiodegradable plastics. However, it is challenging to fabricate polysaccharide-based materials (such as cellulose and chitin) that can be used in humid or even watery environments due to their inferior stability against water. Here, a self-locking structure is constructed to develop a strong, water-resistant, and ionic conductive all-chitosan film without other additives. The densely packed self-locking structure introduces strong interactions between chitosan nanofibers, preventing the fibers from disentangling even in watery environments. The resulting film exhibits outstanding tensile strength of ∼144 MPa, superior wet strength of ∼54.3 MPa, and high ionic conductivity of 0.0012 S/cm at 10 −4 M KCl, which are significantly higher than those of conventional polysaccharide-based materials and many commercially used plastics. Additionally, it also possesses outstanding flexibility, excellent thermal stability, good antimicrobial ability, and biodegradability, which make it a promising eco-friendly alternative to plastics for many potential applications, such as packaging bags, drinking straws, and ion regulation membranes.

show abstract

“…Other scholars have followed this approach by extracting chitin from crustaceans and obtaining nanoscale chitin. [ 63–65 ]…”

Section: Preparation Methods Of Nano‐chitinmentioning

confidence: 99%

“…Other scholars have followed this approach by extracting chitin from crustaceans and obtaining nanoscale chitin. [63][64][65] High-pressure water-jet (HPWJ) system is also a common device for fine treatment of fibers, and the diameter of treated fibers can reach nanometer level. The HPWJ system uses high pressure to inject the fiber suspension into the valve body with a diameter of tens to hundreds of microns and produces a huge pressure gradient around the entrance of the valve hole, so that the fibers in the suspension are subjected to high-speed shearing action to achieve the purpose of initial crushing.…”

Section: Mechanical Treatmentmentioning

confidence: 99%

Recent Progress in Preparation and Application of Nano‐Chitin Materials

Yang

Liu

Pei

et al. 2020

Energy & Environ Materials

View full text Add to dashboard Cite

Chitin is a kind of natural macromolecule material which was first discovered in mushrooms and was widely found in the shells of crustaceans and arthropods, the cell walls of fungi (yeast and mold) and algae, and the mollusks. The original chitin in nature usually has an antiparallel molecular chain alignment forming nanofibers connected by inter-and intramolecular hydrogen bonds. These microfibers consist of nanofibers about 2-5 nm in diameter, and about 300 nm long, embedded by protein matrices. Due to their unique dimensional, optical, mechanical, and other characteristics, the preparation of nano-chitin materials is an important subject. It is possible to extract nano-chitins from their sources with various methods, including acid hydrolysis, mechanical disintegration, TEMPO-mediated oxidation, electrospinning, and others. In this article, the latest progress in recent years in the preparation and applications of nano-chitin were reviewed. The morphology of the nano-chitins obtained from the above methods was presented. The advantages and disadvantages of each method were analyzed. An overview of applications of nano-chitins was discussed, including biomedicine, food applications, water treatment, green electronic materials, enzyme immobilization carriers, cotton textile materials, cosmetics, and others. REVIEW Nano-Chitin Materials

show abstract

High strength gelatin-based nanocomposites reinforced by surface-deacetylated chitin nanofiber networks

Cited by 39 publications

References 31 publications

Effects of Gelatin Methacrylate Bio-ink Concentration on Mechano-Physical Properties and Human Dermal Fibroblast Behavior

Effects of Gelatin Methacrylate Bio-ink Concentration on Mechano-Physical Properties and Human Dermal Fibroblast Behavior

Strong, Water-Resistant, and Ionic Conductive All-Chitosan Film with a Self-Locking Structure

Recent Progress in Preparation and Application of Nano‐Chitin Materials

Contact Info

Product

Resources

About