High strength, biodegradable and cytocompatible alpha tricalcium phosphate-iron composites for temporal reduction of bone fractures

Montúfar, Edgar B.; Casas-Luna, Mariano; Horynová, Miroslava; Tkachenko, Serhii; Fohlerová, Zdenka; Torre, S.D. De la; Dvořák, Karel; Čelko, Ladislav; Kaiser, Jozef

doi:10.1016/j.actbio.2018.02.002

Cited by 31 publications

(25 citation statements)

References 51 publications

(83 reference statements)

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“…The toughening mechanism of TCP-Fe biocermet both in tension and compression was attributed to crack bridging caused by the plastic deformation of Fe reinforcement. Furthermore, Montufar et al [75] incorporated 25 vol% Fe into β-TCP ceramic matrix to prepare β-TCP-Fe biocermet, which presented high mechanical strength and degradation rate, as well as good biocompatibility to osteoblast cells. It was found that there are no significant differences in the tensile strength of the β-TCP-Fe biocermet during 8 weeks' degradation, but a slight decrease after 16 weeks.…”

Section: Tricalcium Phosphate (Tcp)-based Biocermetsmentioning

confidence: 99%

Advances in biocermets for bone implant applications

et al. 2020

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As two promising biomaterials for bone implants, biomedical metals have favorable mechanical properties and good machinability but lack of bioactivity; while bioceramics are known for good biocompatibility or even bioactivity but limited by their high brittleness. Biocermets, a kind of composites composing of bioceramics and biomedical metals, have been developed as an effective solution by combining their complementary advantages. This paper focused on the recently studied biocermets for bone implant applications. Concretely, biocermets were divided into ceramic-based biocermets and metal-based biocermets according to the phase percentages. Their characteristics were systematically summarized, and the fabrication methods for biocermets were reviewed and compared. Emphases were put on the interactions between bioceramics and biomedical metals, as well as the performance improvement mechanisms. More importantly, the main methods for the interfacial reinforcing were summarized, and the corresponding interfacial reinforcing mechanisms were discussed. In addition, the in vitro and in vivo biological performances of biocermets were also reviewed. Finally, future research directions were proposed on the advancement in component design, interfacial reinforcing and forming mechanisms for the fabrication of high-performance biocermets.

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Section: Tricalcium Phosphate (Tcp)-based Biocermetsmentioning

confidence: 99%

Advances in biocermets for bone implant applications

et al. 2020

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“…Compared with Mg-based alloys and Zn-based alloys, Fe-based alloys are used less frequently in soft and hard oral and maxillofacial tissues because of their degradation properties and biological activities. In recent years, researchers have improved the degradation rate of Fe-based materials by alloying [ 261 , 262 ], surface coating [ 52 , 263 ], changing the material structure [ 264 ], or forming composite materials [ 52 , 265 , 266 ]. The addition of manganese (Mn) is an alloying strategy to speed up the corrosion of Fe-based alloys.…”

Section: Fe-based Bms For Oral and Maxillofacial Applicationmentioning

confidence: 99%

Research status of biodegradable metals designed for oral and maxillofacial applications: A review

Xia

Yang

Zheng

et al. 2021

Bioactive Materials

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The oral and maxillofacial regions have complex anatomical structures and different tissue types, which have vital health and aesthetic functions. Biodegradable metals (BMs) is a promising bioactive materials to treat oral and maxillofacial diseases. This review summarizes the research status and future research directions of BMs for oral and maxillofacial applications. Mg-based BMs and Zn-based BMs for bone fracture fixation systems, and guided bone regeneration (GBR) membranes, are discussed in detail. Zn-based BMs with a moderate degradation rate and superior mechanical properties for GBR membranes show great potential for clinical translation. Fe-based BMs have a relatively low degradation rate and insoluble degradation products, which greatly limit their application and clinical translation. Furthermore, we proposed potential future research directions for BMs in the oral and maxillofacial regions, including 3D printed BM bone scaffolds, surface modification for BMs GBR membranes, and BMs containing hydrogels for cartilage regeneration, soft tissue regeneration, and nerve regeneration. Taken together, the progress made in the development of BMs in oral and maxillofacial regions has laid a foundation for further clinical translation.

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“…However, the low mechanical properties and unsatisfactory stability of SMPs always hinder their development in terms of bone repair implants, especially in load-bearing locations [17]. For instance, the modulus of cancellous bone is usually more than 100 MPa, but the modulus of pure polyurethane (PU) falls in the range of ∼10−50 MPa [18,19].…”

Section: Introductionmentioning

confidence: 99%

Isocyanate Modified GO Shape-Memory Polyurethane Composite

Zhang

2020

Polymers

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Shape-memory composites have benefits for minimally invasive surgery, but their wider applications for bone repair are hindered by conflicts between the mechanical and memory performances, especially at load-bearing locations. In this study, we fabricated a graphene oxide shape-memory polyurethane composite through the chemical combination of graphene oxide and isocyanate, in order to realize satisfactory mechanical and shape-memory effects. As desired, a modulus of ~339 MPa and a shape recovery ratio of 98% were achieved, respectively, in the composite. In addition, finite element analysis demonstrated that, after being implanted in a defective bone through a minimally invasive treatment, where the highest stress was distributed at the implant–bone interface, this composite could offer a generated force during the recovery process. Furthermore, we also discuss the origins of the improved mechanical and memory properties of the composites, which arise from increased net-points and the stable molecular structure inside. Therefore, with its superior structure and properties, we envision that this shape-memory composite can provide new insights toward the practical application of shape-memory polymers and composites in the field of bone repair.

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High strength, biodegradable and cytocompatible alpha tricalcium phosphate-iron composites for temporal reduction of bone fractures

Cited by 31 publications

References 51 publications

Advances in biocermets for bone implant applications

Advances in biocermets for bone implant applications

Research status of biodegradable metals designed for oral and maxillofacial applications: A review

Isocyanate Modified GO Shape-Memory Polyurethane Composite

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