High strength and bioactivity polyvinyl alcohol/collagen composite hydrogel with tannic acid as cross‐linker

Bai, Zhongxiang; Wang, Tianyou; Zheng, Xin; Huang, Yanping; Chen, Yining; Dan, Weihua

doi:10.1002/pen.25574

Cited by 55 publications

(35 citation statements)

References 48 publications

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“…[ 3–5 ] Similar to other natural polymers, CLG also lacks sufficient mechanical stability and it is very susceptible to enzymatic degradation from macrophages, polymorph nuclear leukocytes, and bacteria. [ 6, 7 ] Various synthetic cross‐linkers such as glutaraldehyde, epoxy compounds, or oxazolidine increase the tensile strength and resistance to enzymatic degradation of the adsorbent made from only CLG. [ 8 ] However, the amine (─NH 2 ) functionality of CLG, responsible for its electrostatic interaction with dye molecules become unavailable due to chemical crosslinking and the crosslinker also increases toxicity of the CLG.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and adsorption properties of collagen and attapulgite‐filled copolymer biocomposites: Batch and column studies

Choudhury

Ray

2021

Polymer Engineering & Sci

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Several biocomposites were synthesized by copolymerizing hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) at varied molar ratios in the presence of different wt% of collagen (CLG) and attapulgite (APG) clay. The structure and properties of the biocomposite adsorbents were characterized by Fourier transform infrared apectroscopy, nuclear magnetic resonance, X‐ray photo electron spectroscopy, X‐ray diffraction, scanning electron microscope, transfer electron microscopy, energy‐dispersive X‐ray analysis, differential thermal analysis–thermogravimetric analysis, point zero charge analysis, mechanical properties, and pH reversibility tests. The synthesis variables were optimized with a central composite design of response surface methodology (RSM). The biocomposite prepared with an optimized composition of 1.5 wt% CLG, 1.7 wt% APG, and 5:1 molar ratio of HEMA:IA showed an adsorption capacity (Qe, mg/g) of 674.4/602.4 for methylene blue (MB)/Rose Bengal (RB) dye from a feed containing 200 mg/L of MB + RB dye mixture in batch mode. In a fixed bed in column mode, the optimized biocomposite showed a removal% of 82.8/71.3 for 100 mg/L inlet concentration, 20 ml/min flow rate, and 20 mm bed height with a breakthrough time of 23/31 min and a mass transfer coefficient (kmtc × 105 cm/s) of 8.36/7.67 for MB/RB as single dye solution.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and adsorption properties of collagen and attapulgite‐filled copolymer biocomposites: Batch and column studies

Choudhury

Ray

2021

Polymer Engineering & Sci

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“…Still, their biological inertness, blocking any chances of tuning cell behavior towards a healthier state, limits their use in biomedicine [ 63 , 64 ]. Hybrid hydrogels, combining natural and synthetic polymers [ 65 ], have been proven useful to create smart hydrogels (alginate-g-(PEO-poly(propylene oxide)-PEO) [ 66 ]), in biomedical materials (PVA/collagen [ 67 ]) and in tissue engineering applications (CS/PCL [ 47 ]), to name a few examples. Their polymer composition may also subdivide hydrogels in homopolymers, copolymers, multipolymers or interpenetrating polymer networks (IPN) [ 68 ].…”

Section: Hydrogelmentioning

confidence: 99%

Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

2021

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In the last decades, much research has been done to fasten wound healing and target-direct drug delivery. Hydrogel-based scaffolds have been a recurrent solution in both cases, with some reaching already the market, even though their mechanical stability remains a challenge. To overcome this limitation, reinforcement of hydrogels with fibers has been explored. The structural resemblance of fiber–hydrogel composites to natural tissues has been a driving force for the optimization and exploration of these systems in biomedicine. Indeed, the combination of hydrogel-forming techniques and fiber spinning approaches has been crucial in the development of scaffolding systems with improved mechanical strength and medicinal properties. In this review, a comprehensive overview of the recently developed fiber–hydrogel composite strategies for wound healing and drug delivery is provided. The methodologies employed in fiber and hydrogel formation are also highlighted, together with the most compatible polymer combinations, as well as drug incorporation approaches creating stimuli-sensitive and triggered drug release towards an enhanced host response.

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“…Periodate compounds are commonly used for the oxidation of functional groups [ 15 ] and could be used for the selective oxidation of vicinal diols to aldehyde groups [ 16 ]. Usage of those oxidizers is well known for obtaining hydrogels, linking tannin in their network [ 17 , 18 , 19 ]. Additionally, increasing the pH in oxidation reactions with periodate-containing substances is another important thing to mention.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Oxidant on Gelatin–Tannin Hydrogel Properties and Structure for Potential Biomedical Application

2021

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Nowadays, there is a widespread usage of sodium periodate as an oxidant for synthesizing gelatin–tannin hydrogels. The impact of iodine compounds could have a harmful effect on human health. The study focuses on the proposal of alternative oxidizing systems for tannin oxidation. Gelatin–tannin hydrogels were obtained based on the usage of H2O2/DMSO/KMnO4/KIO4 oxidants and characterized with sorption, thermal (TGA, DTG, DSC), mechanical, FTIR and other methods. The sorption experiments were carried out in a phosphate buffer (pH = 5.8/7.4/9) and distilled water and were investigated with Fick’s law and pseudosecond order equation. The pH dependence of materials in acid media indicates the possibility of further usage as stimuli-responsive systems for drug delivery. Thermal transitions demonstrate the variation of structure with melting (306 ÷ 319 °C) and glass transition temperatures (261 ÷ 301 °C). The activation energy of water evaporation was calculated by isoconversional methods (Kissinger–Akahira–Sunose, Flynn–Wall–Ozawa) ranging from 4 ÷ 18 to 14 ÷ 38 kJ/mole and model-fitting (Coats–Redfern, Kennedy–Clark) methods at 24.7 ÷ 45.3 kJ/mole, indicating the smooth growth of values with extent of conversion. The network parameters of the hydrogels were established by modified Flory–Rehner and rubber elasticity theories, which demonstrated differences in values (5.96 ÷ 21.27·10−3 mol/cm3), suggesting the limitations of theories. The sorption capacity, tensile strength and permeability for water/oxygen indicate that these materials may find their application in field of biomaterials.

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High strength and bioactivity polyvinyl alcohol/collagen composite hydrogel with tannic acid as cross‐linker

Cited by 55 publications

References 48 publications

Synthesis, characterization, and adsorption properties of collagen and attapulgite‐filled copolymer biocomposites: Batch and column studies

Synthesis, characterization, and adsorption properties of collagen and attapulgite‐filled copolymer biocomposites: Batch and column studies

Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

The Influence of Oxidant on Gelatin–Tannin Hydrogel Properties and Structure for Potential Biomedical Application

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