High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting

Bayliak, Maria M.; Sorochynska, Oksana M.; Kuzniak, Oksana V.; Drohomyretska, Ivanna Z.; Klonovskyi, Andriy Ya.; Hrushchenko, Anastasia O.; Vatashchuk, Myroslava; Mosiichuk, Nadia M.; Storey, Kenneth B.; Garaschuk, Olga; Lushchak, Volodymyr I.

doi:10.1007/s10522-022-09982-x

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…As a result, the overall decrease in ATP production deprives brain cells of the energy they need to perform their physiological functions ( Mohamad Kamal et al, 2020 ). Moreover, we found that proteins belonging to tricarboxylic acid/dicarboxylic acid metabolic processes, namely glutamate dehydrogenase, isocitrate dehydrogenase, and malate dehydrogenase 1 ( Dong and Brewer, 2019 ; Aldana et al, 2020 ; Bayliak et al, 2022 ), were down-regulated in the old animal samples, thus allowing us to hypothesize a crucial role of the mitochondrial homeostasis and metabolism upon the modulation of the age-dependent bioenergetics and cognitive processes.…”

Section: Discussionmentioning

confidence: 95%

Proteomic signature profiling in the cortex of dairy cattle unravels the physiology of brain aging

Cozzolino,

Canè,

Gatto

et al. 2023

Front. Aging Neurosci.

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IntroductionAging is a physiological process occurring in all living organisms. It is characterized by a progressive deterioration of the physiological and cognitive functions of the organism, accompanied by a gradual impairment of mechanisms involved in the regulation of tissue and organ homeostasis, thus exacerbating the risk of developing pathologies, including cancer and neurodegenerative disorders.MethodsIn the present work, for the first time, the influence of aging has been investigated in the brain cortex of the Podolica cattle breed, through LC–MS/MS-based differential proteomics and the bioinformatic analysis approach (data are available via ProteomeXchange with identifier PXD044108), with the aim of identifying potential aging or longevity markers, also associated with a specific lifestyle.Results and discussionWe found a significant down-regulation of proteins involved in cellular respiration, dendric spine development, synaptic vesicle transport, and myelination. On the other hand, together with a reduction of the neurofilament light chain, we observed an up-regulation of both GFAP and vimentin in the aged samples. In conclusion, our data pave the way for a better understanding of molecular mechanisms underlying brain aging in grazing cattle, which could allow strategies to be developed that are aimed at improving animal welfare and husbandry practices of dairy cattle from intensive livestock.

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