High-speed X-ray phase imaging and X-ray phase tomography with Talbot interferometer and white synchrotron radiation

Momose, Atsushi; Yashiro, Wataru; Maikusa, Hirohide; Takeda, Yoshihiro

doi:10.1364/oe.17.012540

Cited by 133 publications

(90 citation statements)

References 12 publications

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“…Furthermore, the surface dose can be significantly reduced through an optimization of the experimental setup-namely, thinning of the grating wafers (which currently comprise 1 mm of silicon), optimization of grating design energy, and an overall increase in X-ray energy. Shorter exposure times can be achieved by using single-shot Moiré techniques (42,43), where image resolution is reduced, while the sensitivity of the dark-field signal to changes in lung structure is not altered.…”

Section: Discussionmentioning

confidence: 99%

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

Schleede

Meinel²,

Bech

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

174

128

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In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.

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Section: Discussionmentioning

confidence: 99%

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

Schleede

Meinel²,

Bech

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

174

128

View full text Add to dashboard Cite

show abstract

“…[6][7][8][9] In terms of microtomography, a thirdgeneration synchrotron radiation source provides partially coherent x-ray beam with enough brilliance to image a millimeter-sized sample at better than 10/micropixel resolution in a few seconds with high sensitivity. [10][11][12] In comparison to other nondestructive inspection techniques, such as magnetic resonance imaging, conventional micro-CT, and confocal microscopy, synchrotron-radiation-based micro-CT (SR-μCT) provides the unique capability of performing 3D dynamic studies. In SR-μCT, a synchrotron source can deliver intense x-rays over a wide energy spectrum, ranging from a few electrovolts to more than a hundred kiloelectrovolts.…”

Section: Introductionmentioning

confidence: 99%

Image reconstruction from sparse data in synchrotron-radiation-based microtomography

Xia

Xiao

Bian

et al. 2011

Review of Scientific Instruments

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Synchrotron-radiation-based microcomputed-tomography (SR-μCT) is a powerful tool for yielding 3D structural information of high spatial and contrast resolution about a specimen preserved in its natural state. A large number of projection views are required currently for yielding SR-μCT images by use of existing algorithms without significant artifacts. When a wet biological specimen is imaged, synchrotron x-ray radiation from a large number of projection views can result in significant structural deformation within the specimen. A possible approach to reducing imaging time and specimen deformation is to decrease the number of projection views. In the work, using reconstruction algorithms developed recently for medical computed tomography (CT), we investigate and demonstrate image reconstruction from sparse-view data acquired in SR-μCT. Numerical results of our study suggest that images of practical value can be obtained from data acquired at a number of projection views significantly lower than those used currently in a typical SR-μCT imaging experiment.

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“…Transfer function due to finite focal spot T 3 Transfer function due to spread of optical photons T 5 Transfer function due to photodiode aperture T 10 Reconstruction kernel T 11 Apodization filter T 12 Interpolation filter T 13 Backprojection transfer function 13 Backprojection transfer function of the noise…”

Section: Iia Differential Phase Contrast Imagingmentioning

confidence: 99%

Fundamental relationship between the noise properties of grating-based differential phase contrast CT and absorption CT: Theoretical framework using a cascaded system model and experimental validation

Bevins

Zambelli

et al. 2013

Med. Phys.

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Purpose: Using a grating interferometer, a conventional x-ray cone beam computed tomography (CT) data acquisition system can be used to simultaneously generate both conventional absorption CT (ACT) and differential phase contrast CT (DPC-CT) images from a single data acquisition. Since the two CT images were extracted from the same set of x-ray projections, it is expected that intrinsic relationships exist between the noise properties of the two contrast mechanisms. The purpose of this paper is to investigate these relationships. Methods: First, a theoretical framework was developed using a cascaded system model analysis to investigate the relationship between the noise power spectra (NPS) of DPC-CT and ACT. Based on the derived analytical expressions of the NPS, the relationship between the spatial-frequencydependent noise equivalent quanta (NEQ) of DPC-CT and ACT was derived. From these fundamental relationships, the NPS and NEQ of the DPC-CT system can be derived from the corresponding ACT system or vice versa. To validate these theoretical relationships, a benchtop cone beam DPC-CT/ACT system was used to experimentally measure the modulation transfer function (MTF) and NPS of both DPC-CT and ACT. The measured three-dimensional (3D) MTF and NPS were then combined to generate the corresponding 3D NEQ. Results: Two fundamental relationships have been theoretically derived and experimentally validated for the NPS and NEQ of DPC-CT and ACT: (1) the 3D NPS of DPC-CT is quantitatively related to the corresponding 3D NPS of ACT by an inplane-only spatial-frequency-dependent factor 1/f 2 , the ratio of window functions applied to DPC-CT and ACT, and a numerical factor C g determined by the geometry and efficiency of the grating interferometer. Note that the frequency-dependent factor is independent of the frequency component f z perpendicular to the axial plane. (2) The 3D NEQ of DPC-CT is related to the corresponding 3D NEQ of ACT by an f 2 scaling factor and numerical factors that depend on both the attenuation and refraction properties of the image object, as well as C g and the MTF of the grating interferometer. Conclusions: The performance of a DPC-CT system is intrinsically related to the corresponding ACT system. As long as the NPS and NEQ of an ACT system is known, the corresponding NPS and NEQ of the DPC-CT system can be readily estimated using additional characteristics of the grating interferometer.

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High-speed X-ray phase imaging and X-ray phase tomography with Talbot interferometer and white synchrotron radiation

Cited by 133 publications

References 12 publications

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

Image reconstruction from sparse data in synchrotron-radiation-based microtomography

Fundamental relationship between the noise properties of grating-based differential phase contrast CT and absorption CT: Theoretical framework using a cascaded system model and experimental validation

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