High-speed nanometer-resolved imaging vibrometer and velocimeter

Mahjoubfar, Ata; Goda, Keisuke; Ayazi, Ali; Fard, Ali; Kim, Sang Hyup; Jalali, Bahram

doi:10.1063/1.3563707

Cited by 73 publications

(29 citation statements)

References 11 publications

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“…Ultrafast imaging has traditionally been used to observe fast transient dynamics in a fixed object (e.g., explosions and chemical reactions) [2,21], but can also be used for monitoring, evaluating, and characterizing a large number of objects in a short period of time for highprecision statistical analysis. For this reason, STEAM has been found the most useful in applications that require fast continuous monitoring, such as surface inspection of parts for manufacturing and quality control [22,23], surface vibrometry for diagnosing aerospace components and music instruments [24,25], and flow cytometry of biological cells [26,27].…”

Section: Serial Time-encoded Amplified Imaging / Microscopy (Steam)mentioning

confidence: 99%

Ultrafast optical imaging technology: principles and applications of emerging methods

2016

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High-speed optical imaging is an indispensable technology for blur-free observation of fast transient dynamics in virtually all areas including science, industry, defense, energy, and medicine. High temporal resolution is particularly important for microscopy as even a slow event appears to occur "fast" in a small field of view. Unfortunately, the shutter speed and frame rate of conventional cameras based on electronic image sensors are significantly constrained by their electrical operation and limited storage. Over the recent years, several unique and unconventional approaches to high-speed optical imaging have been reported to circumvent these technical challenges and achieve a frame rate and shutter speed far beyond what can be reached with the conventional image sensors. In this article, we review the concepts and principles of such ultrafast optical imaging methods, compare their advantages and disadvantages, and discuss an entirely new class of applications that are possible using them.

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Section: Serial Time-encoded Amplified Imaging / Microscopy (Steam)mentioning

confidence: 99%

Ultrafast optical imaging technology: principles and applications of emerging methods

2016

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“…Primarily because of the wide availability of the lowloss dispersive fibers-the key element for the timestretch process-in the telecommunication band (∼1550 nm), the prior works on time-stretch imaging were all demonstrated in this wavelength band [1,[4][5][6][7]. However, its potential use in a more favorable spectral window for biophotonic applications (∼1 μm) is yet to be explored so far.…”

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confidence: 96%

“…Because of the low fiber loss (<1 dB ∕ km), we can afford to use a longer fiber to further enhance the GVD, and thus to achieve the spatial-dispersion-limited resolution. More importantly, the intrinsic dispersive loss can be circumvented by optically amplifying the timestretched signal either using distributed Raman amplification in the same fiber [1,[4][5][6]9,11,12] or the discrete optical amplifiers, which are commonly available in the 1 μm range (e.g., YDFA, and semiconductor optical amplifiers).…”

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confidence: 99%

Optical time-stretch confocal microscopy at 1 μm

et al. 2012

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We demonstrate optical time-stretch confocal microscopy in the 1 μm spectral window for high-speed and high-resolution cellular imaging. In contrast to the prior demonstrations of time-stretch imaging, which all operated in the telecommunication band, the present work extends the utility of this imaging modality to a wavelength regime (~1 μm), which is well known to be the optimal diagnostic window in biophotonics. This imaging technique enables us to image the nasopharyngeal epithelial cells with cellular resolution (<2 μm), at a line scan rate of 10 MHz, and with a field of view as wide as ~0.44 mm × 0.1 mm. We also theoretically and experimentally characterized the system performance. As the low-loss dispersive fibers for the time-stretch process as well as other essential optical components for enhancing the imaging sensitivity are commonly available at 1 μm, time-stretch confocal microscopy in this wavelength range could usher in realizing high-speed cell imaging with an unprecedented throughput.

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“…High-throughput real-time instruments are needed to acquire large data sets and to detect and classify rare events. Examples include the time stretch camera [2][3][4][5][6][7][8][9][10][11][12]-a MHz-frame-rate bright-field imager, and the fluorescence imaging using radio frequency-tagged excitation (FIRE)-an ultra-high-frame-rate fluorescent camera for biological imaging [13]. The record throughputs of these instruments have enabled the discovery of optical rogue waves [14], the detection of cancer cells in blood with false positive rate of one cell in a million [15], and the highest performance analog-to-digital converter ever reported [16].…”

Section: Introductionmentioning

confidence: 99%

Optical Data Compression in Time Stretch Imaging

Mahjoubfar¹,

Chen²,

Jalali³

2017

Artificial Intelligence in Label-Free Microscopy

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Time stretch imaging offers real-time image acquisition at millions of frames per second and subnanosecond shutter speed, and has enabled detection of rare cancer cells in blood with record throughput and specificity. An unintended consequence of high throughput image acquisition is the massive amount of digital data generated by the instrument. Here we report the first experimental demonstration of real-time optical image compression applied to time stretch imaging. By exploiting the sparsity of the image, we reduce the number of samples and the amount of data generated by the time stretch camera in our proof-of-concept experiments by about three times. Optical data compression addresses the big data predicament in such systems.

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High-speed nanometer-resolved imaging vibrometer and velocimeter

Cited by 73 publications

References 11 publications

Ultrafast optical imaging technology: principles and applications of emerging methods

Ultrafast optical imaging technology: principles and applications of emerging methods

Optical time-stretch confocal microscopy at 1 μm

Optical Data Compression in Time Stretch Imaging

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