High speed and high density organic electrochemical transistor arrays

Khodagholy, Dion; Gurfinkel, M.; Stavrinidou, Eleni; Leleux, Pierre; Hervé, Thierry; Sanaur, Sébastien; Malliaras, George G.

doi:10.1063/1.3652912

Cited by 100 publications

(80 citation statements)

References 16 publications

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“…22 It has also been shown that one can conduct photolithography on parylene, which enables the fabrication of micro-patterned electrode structures on parylene. 23 …”

Section: Resultsmentioning

confidence: 99%

Towards flexible organic thin film transistors (OTFTs) for biosensing

Werkmeister

Nickel

2013

J. Mater. Chem. B

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We have studied parylene-N and parylene-C for their use as substrates and gate dielectrics in OTFTs. Parylene-N films with a thickness of 300 nm show the required dielectric properties, as verified by breakthrough-voltage measurements. The surface roughness measured for 300 nm thick parylene-N films is 4-5 nm. However, initial growth of parylene depends on the subjacent surface. This results in different thicknesses on Au electrodes and substrate materials for thin films. Capping of micro-

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“…22 It has also been shown that one can conduct photolithography on parylene, which enables the fabrication of micro-patterned electrode structures on parylene. 23 …”

Section: Resultsmentioning

confidence: 99%

Towards flexible organic thin film transistors (OTFTs) for biosensing

Werkmeister

Nickel

2013

J. Mater. Chem. B

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“…The fabrication and in vivo validation of PEDOT:PSS electrodes34 and the patterning of PEDOT:PSS OECTs38 were discussed in previous publications. Here we used an adapted fabrication process that involved the deposition and patterning of parylene, Au and PEDOT:PSS films as follows: Parylene C was deposited using an SCS Labcoater 2 to a thickness of 2 μm (at which thickness parylene films are pinhole-free).…”

Section: Methodsmentioning

confidence: 99%

In vivo recordings of brain activity using organic transistors

et al. 2013

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In vivo electrophysiological recordings of neuronal circuits are necessary for diagnostic purposes and for brain-machine interfaces. Organic electronic devices constitute a promising candidate because of their mechanical flexibility and biocompatibility. Here we demonstrate the engineering of an organic electrochemical transistor embedded in an ultrathin organic film designed to record electrophysiological signals on the surface of the brain. The device, tested in vivo on epileptiform discharges, displayed superior signal-to-noise ratio due to local amplification compared with surface electrodes. The organic transistor was able to record on the surface low-amplitude brain activities, which were poorly resolved with surface electrodes. This study introduces a new class of biocompatible, highly flexible devices for recording brain activity with superior signal-to-noise ratio that hold great promise for medical applications.

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“…Recent advances have permitted the development of OECTs that can transduce low level gate currents over a broad range of frequencies. 19,20 This new generation of devices has a flat band frequency response up to at least 1-10 kHz. In this letter, we demonstrate the use of the OECT to carry out electrochemical impedance spectroscopy on epithelial layers, with the goal of demonstrating high confidence at both low and high frequencies.…”

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confidence: 99%

Organic electrochemical transistors for cell-based impedance sensing

Rivnay

Ramuz

Leleux

et al. 2015

Applied Physics Letters

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105

156

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Electrical impedance sensing of biological systems, especially cultured epithelial cell layers, is now a common technique to monitor cell motion, morphology, and cell layer/tissue integrity for high throughput toxicology screening. Existing methods to measure electrical impedance most often rely on a two electrode configuration, where low frequency signals are challenging to obtain for small devices and for tissues with high resistance, due to low current. Organic electrochemical transistors (OECTs) are conducting polymer-based devices, which have been shown to efficiently transduce and amplify low-level ionic fluxes in biological systems into electronic output signals. In this work, we combine OECT-based drain current measurements with simultaneous measurement of more traditional impedance sensing using the gate current to produce complex impedance traces, which show low error at both low and high frequencies. We apply this technique in vitro to a model epithelial tissue layer and show that the data can be fit to an equivalent circuit model yielding trans-epithelial resistance and cell layer capacitance values in agreement with literature. Importantly, the combined measurement allows for low biases across the cell layer, while still maintaining good broadband signal.

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High speed and high density organic electrochemical transistor arrays

Cited by 100 publications

References 16 publications

Towards flexible organic thin film transistors (OTFTs) for biosensing

Towards flexible organic thin film transistors (OTFTs) for biosensing

In vivo recordings of brain activity using organic transistors

Organic electrochemical transistors for cell-based impedance sensing

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