High-specificity protection against radiation-induced bone loss by a pulsed electromagnetic field

Yan, Zedong; Wang, Dan; Cai, Jing; Shen, Liangliang; Jiang, Maogang; Liu, Xiyu; Huang, Jinghui; Zhang, Yong; Luo, Erping; Jing, Da

doi:10.1126/sciadv.abq0222

Cited by 10 publications

(5 citation statements)

References 67 publications

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“…Tis study gains insights into the mechanism of osteogenic diferentiation that may contribute to new strategies for the prevention and treatment of PMOP and even other metabolic bone diseases (Figure 7). It is reported that PEMF has multiple biological functions in bone metabolism, including promoting osteogenesis, [39,40] attenuating osteoclast activity [41,42], inhibiting cellular infammation [43,44], etc. PEMF is also a novel potential physiotherapy to promote osteogenesis and has attractive traits including good safety, noninvasiveness, low cost, and easy operation [15].…”

Section: Discussionmentioning

confidence: 99%

Pulsed Electromagnetic Field Promotes Bone Anabolism in Postmenopausal Osteoporosis through the miR-6976/BMP/Smad4 Axis

Huang

Zhu

et al. 2023

Journal of Tissue Engineering and Regenerative Medicine

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Background. Insufficient bone formation is the key reason for the imbalance of bone metabolism and one of the main mechanisms for the occurrence and deterioration of postmenopausal osteoporosis (PMOP). Accumulating evidence has demonstrated that pulsed electromagnetic field (PEMF), as a physiotherapy, can treat osteoporosis by promoting osteogenic differentiation in osteoblasts. However, little is known about its mechanisms. Methods. In vivo, ovariectomized mice were administered PEMF for 4 weeks, and skeletal analysis was conducted. In vitro, hydrogen peroxide-treated mouse osteoblast precursor cells with or without PEMF intervention were subjected to osteogenic differentiation testing and miRNA microarrays. The potential target miRNAs were validated, followed by gene expression assays to further clarify their regulatory relationships with target pathways. Results. We found that PEMF reduced bone loss in ovariectomized mice and promoted osteogenic differentiation of hydrogen peroxide-treated osteoblast precursor cells via downregulation of miR-6976-5p. Mechanistically, reduced miR-6976-5p enhanced the nuclear transport of phosphorylated Smad1/5/9 by upregulating Smad4, thereby activating the BMP/Smad pathway. Additionally, the administration of miR-6976-5p inhibitors successfully promoted osteogenic differentiation in vitro, and its antagomirs protected bone mass in vivo. miR-6976-5p mimics and agomirs acted in the opposite way. Conclusion. These results provide evidence that PEMF alleviates estrogen deficiency-induced bone loss by activating osteoblastic progenitor cells and maintaining their osteogenic differentiation and shed light on the mechanisms involved, which may provide a potential option for the clinical application of PEMF in PMOP.

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Section: Discussionmentioning

confidence: 99%

Pulsed Electromagnetic Field Promotes Bone Anabolism in Postmenopausal Osteoporosis through the miR-6976/BMP/Smad4 Axis

Huang

Zhu

et al. 2023

Journal of Tissue Engineering and Regenerative Medicine

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“…The optimal waveform and parameter regimen for a particular site of fracture, as well as the electromagnetic field sensation and signalling mechanisms in osteoblasts, remain unclear. Therefore, further exploration of these parameters and mechanisms is required to guide clinical treatment ( Maziarz et al, 2016 ; Yan et al, 2022 ).…”

Section: Research Progress On Pemf Applications In Bone Repairmentioning

confidence: 99%

Signalling pathways underlying pulsed electromagnetic fields in bone repair

Wang,

Ma,

Bian

et al. 2024

Front. Bioeng. Biotechnol.

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Pulsed electromagnetic field (PEMF) stimulation is a prospective non-invasive and safe physical therapy strategy for accelerating bone repair. PEMFs can activate signalling pathways, modulate ion channels, and regulate the expression of bone-related genes to enhance osteoblast activity and promote the regeneration of neural and vascular tissues, thereby accelerating bone formation during bone repair. Although their mechanisms of action remain unclear, recent studies provide ample evidence of the effects of PEMF on bone repair. In this review, we present the progress of research exploring the effects of PEMF on bone repair and systematically elucidate the mechanisms involved in PEMF-induced bone repair. Additionally, the potential clinical significance of PEMF therapy in fracture healing is underscored. Thus, this review seeks to provide a sufficient theoretical basis for the application of PEMFs in bone repair.

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“…For this aspect, there are multiple related reviews where people can find more information. [9][10][11] For SMFs, although they have not been FDA-approved, there are also quite a few reports related to its potential application in bone regeneration (Table I), which show that SMFs have multiple beneficial effects on the bone systems both in vitro and in vivo.…”

Section: Bone Regenerationmentioning

confidence: 99%

Static magnetic fields in regenerative medicine

Xie,

Song,

Guo

et al. 2024

APL Bioengineering

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All organisms on Earth live in the weak but ubiquitous geomagnetic field. Human beings are also exposed to magnetic fields generated by multiple sources, ranging from permanent magnets to magnetic resonance imaging (MRI) in hospitals. It has been shown that different magnetic fields can generate various effects on different tissues and cells. Among them, stem cells appear to be one of the most sensitive cell types to magnetic fields, which are the fundamental units of regenerative therapies. In this review, we focus on the bioeffects of static magnetic fields (SMFs), which are related to regenerative medicine. Most reports in the literature focus on the influence of SMF on bone regeneration, wound healing, and stem cell production. Multiple aspects of the cellular events, including gene expression, cell signaling pathways, reactive oxygen species, inflammation, and cytoskeleton, have been shown to be affected by SMFs. Although no consensus yet, current evidence indicates that moderate and high SMFs could serve as a promising physical tool to promote bone regeneration, wound healing, neural differentiation, and dental regeneration. All in vivo studies of SMFs on bone regeneration and wound healing have shown beneficial effects, which unravel the great potential of SMFs in these aspects. More mechanistic studies, magnetic field parameter optimization, and clinical investigations on human bodies will be imperative for the successful clinical applications of SMFs in regenerative medicine.

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High-specificity protection against radiation-induced bone loss by a pulsed electromagnetic field

Cited by 10 publications

References 67 publications

Pulsed Electromagnetic Field Promotes Bone Anabolism in Postmenopausal Osteoporosis through the miR-6976/BMP/Smad4 Axis

Pulsed Electromagnetic Field Promotes Bone Anabolism in Postmenopausal Osteoporosis through the miR-6976/BMP/Smad4 Axis

Signalling pathways underlying pulsed electromagnetic fields in bone repair

Static magnetic fields in regenerative medicine

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