High SLC17A9 Expression Correlates with Poor Survival in Gastric Carcinoma

Li, Junqing; Su, Taiqiang; Deng, Lingna; Zhang, Changhua

doi:10.2217/fon-2019-0283

Cited by 15 publications

(18 citation statements)

References 30 publications

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“…Western blotting and immunohistochemical examination revealed that the expression of SLC17A9 in cancer tissue of patients with rectal cancer was significantly higher than that of adjacent tissues, and was significantly related to the poor prognosis of patients. To date, few studies (19)(20)(21) have reported the importance of SLC17A9 in HCC. The present study revealed that SLC17A9 was mainly located in the cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…Results revealed that patients with high expression of SLC17A9 had higher Edmondson grade and higher rate of distant metastasis, which may be related to tumor invasiveness and metastasis of HCC, however the expression of SLC17A9 was not related to age, sex, tumor size, tumor number and liver cirrhosis (P>0.05). At present, it has rarely been reported that the expression of SLC17A9 is associated with the clinicopathological parameters of cancer patients (20,21). It has previously been revealed that the high expression of SLC17A9 was closely related to the TNM stage of cancer patients in oral squamous cell carcinoma (21).…”

Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 97%

“…At present, it has rarely been reported that the expression of SLC17A9 is associated with the clinicopathological parameters of cancer patients (20,21). It has previously been revealed that the high expression of SLC17A9 was closely related to the TNM stage of cancer patients in oral squamous cell carcinoma (21).…”

Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 97%

“…These results indicated that SLC17A9 expression is a new biomarker for potentially predictable prognosis in patients with HCC. The association between SLC17A9 expression and cancer prognosis was limited to two different types of tumors (20,21). The high expression of SLC17A9 in patients with CRC was related to the poor prognosis of patients with colorectal cancer.…”

Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 99%

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Expression of SLC17A9 in hepatocellular carcinoma and its clinical significance

2020

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The present study aimed to investigate the expression and clinical significance of solute carrier family 17 member 9 (SLC17A9) in cancer tissues of patients with hepatocellular carcinoma (HCC). Ninety-eight patients with HCC were admitted to our hospital from January 2010 to December 2014. Their clinical data was retrospectively analyzed. The expression of SLC17A9 in HCC cancer tissues was detected by immunohistochemistry. Kaplan-Meier curve, log-rank test and Cox proportional hazard model analysis were used to analyze the tumor-free survival rate and overall survival rate. SLC17A9 expression was associated with Edmondson grade (P=0.04) and distant metastasis (P=0.03). The tumor-free survival (P=0.03) and overall survival (P= 0.01) of SLC17A9-high expression patients were significantly lower than those in SLC17A9-low expression patients. Multivariate analysis revealed that SLC17A9 expression (HR, 0.77; 95% CI, 0.27-2.47, P= 0.02) was an independent risk factor for tumor-free survival in patients with HCC, and the expression of SLC17A9 (HR, 1.81; 95% CI, 0.99-3.77, P=0.04) was an independent risk factor for overall survival in patients with HCC. In conclusion, SLC17A9 can be used as a new molecular marker to predict the poor prognosis of patients with HCC.

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Section: Discussionmentioning

confidence: 99%

Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 97%

Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 97%

Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 99%

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Expression of SLC17A9 in hepatocellular carcinoma and its clinical significance

2020

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“…EnVision Plus System-HRP (DAKO, Denmark) was used according to manufacturer's instruction and targeted protein was visualized using diaminobenzidine (DAB) as the substrate. And the nucleus was displayed by Mayer's hematoxylin counterstaining [21].…”

Section: Immunohistochemical Staining and Evaluationmentioning

confidence: 99%

Overexpression of TC2N is associated with poor prognosis in gastric cancer

et al. 2020

Preprint

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Abstract Background Tac2-N (TC2N) is a tandem C2 domain-containing protein, acting as a novel oncogene or suppressor in different kinds of cancers. However, the status of TC2N expression and its significance in gastric cancer (GC) is still unclear. The present study is aimed to elucidate the clinicopathological significance and prognostic value of TC2N level in GC. Methods We used sequencing data from the Cancer Genome Atlas (TCGA) database to analyze TC2N expression in GC by UALCAN database and Gene Expression Profiling Interactive Analysis tools (GEPIA). TC2N expression level in 12 pairs of fresh GC tissues and adjacent nontumorous tissues was detected by quantitative real-time reverse-transcription polymerase chain reaction(RT-PCR)and Western blot(WB) assays. Immunohistochemical (IHC) staining was used to detect TC2N protein expression in Paraffin-embedded tissues in our center. In vitro proliferation, migration and invasion assays were used to evaluate the effect of TC2N on functional capability of gastric cancer cells. LinkedOmics was used to identify gene expressions associated with TC2N. Results The mRNA and protein expression of TC2N in gastric cancer were both significantly higher than normal gastric mucosa. It was also elevated in gastric cancer cells compared with normal gastric epithelium cell. In vitro assays suggested that TC2N facilitated proliferation, migration and invasion of gastric cancer cells. Bioinformatic analysis showed a widespread impact of TC2N on the transcriptome and a strong interaction with tumor associated genes. We also found that TC2N was an independent prognostic factor for long-term survival in GC patients and its high expression was significantly associated with poor overall survival and recurrence-free survival. Conclusions Our results show that high level of TC2N correlates with poor prognosis in patients with gastric cancer and promotes the development of gastric cancer. Thus, TC2N expression can serve as a prognostic biomarker for patients with gastric cancer.

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