High-shear-stress-induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells

Nomura, Shosaku; Tandon, Narendra N.; Nakamura, Takashi; Cone, James; Fukuhara, Shirou; Kambayashi, Jun-ichi

doi:10.1016/s0021-9150(01)00433-6

Cited by 271 publications

(240 citation statements)

References 66 publications

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“…32 There is experimental evidence that endothelial cells exposed to the shear stress resulting from elevated BP increase their production of IL-6 and TNF-a. 37,38 Unfortunately, there are few if any human data on the effect of elevated BP on the synthesis of cytokines and CRP. We have found no changes in CRP levels in subjects with drug-controlled hypertension as compared to noncontrolled subjects, 32 which suggests that CRP levels are not a consequence of elevated BP.…”

Section: Discussionmentioning

confidence: 99%

Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension

et al. 2004

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High blood pressure (HBP) has been associated with elevated C-reactive protein (CRP), a marker of chronic mild inflammation. However, the association between HBP and other inflammatory markers, particularly interleukin 6 (IL-6) and tumour necrosis alpha (TNF-a), has not been evaluated in well-controlled studies. We examined the cross-sectional relationship between IL-6, TNF-a, and CRP and HBP in a random sample of 196 healthy subjects. All markers were measured in duplicate with high-sensitivity ELISA tests. Three blood pressure (BP) measurments were averaged for the analysis, and subjects with systolic BP X140 and/or diastolic BP X90 mmHg were considered hypertensive. Log binomial regression was used to estimate multivariate-adjusted prevalence ratios (PR) of HBP. Of the subjects, 40% (79) were hypertensive (mean age: 44 years; range 30-64). After adjustment for age, sex, body mass index, family history of HBP, and the level of the other inflammatory markers, subjects in the second (PR: 3.10, P ¼ 0.003), third (PR: 2.32; P ¼ 0.031), and fourth quartiles (PR: 2.30; P ¼ 0.036) of IL-6 were more than twice as likely to be hypertensive than those in the first quartile. Corresponding PR estimates for TNF-a levels were 1.41 (P ¼ 0.014) for the second; 1.59 (P ¼ 0.001) for the third; and 1.61 (P ¼ 0.025) for the fourth quartile. The CRP-HBP association was not statistically significant. Our results suggest that TNF-a and IL-6 could be independent risk factors for HBP in apparently healthy subjects. Nevertheless, the temporal relationship between elevated inflammation markers and HBP should be ascertained in prospective cohort studies.

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Section: Discussionmentioning

confidence: 99%

Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension

et al. 2004

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“…54 Platelet MPs also simulate endothelial cells in vitro to release cytokines and express adhesion molecule. 55 In addition, platelet MPs can directly interact with activated vascular endothelial cells by increasing leukocytes/monocytes arrest after transcellu- lar delivery of the chemokine Regulated on Activation, Normal T Expressed and Secreted (RANTES). 56 MPs also impair the release of NO from vascular endothelial cells.…”

Section: Plasma Levels Of Mps In Cardiovascular Diseasesmentioning

confidence: 99%

Circulating Microparticles

2006

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“…81 Also, endothelial cells exposed to increased shear stress, as expected in HBP, increase their production of IL-1b, IL-6, IL-8, and TNF-a. 82,83 Finally, HBP may cause intramural hypoxia, which could increase the synthesis of free radicals and lead to IEDD. 84 However, HBP is an unlikely major determinant of MCI, because CRP level has been only weakly associated to prevalent cardiovascular disease and subclinical measures of atherosclerosis.…”

mentioning

confidence: 99%

Inflammation, endothelial dysfunction, and the risk of high blood pressure: epidemiologic and biological evidence

2003

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High-shear-stress-induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells

Cited by 271 publications

References 66 publications

Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension

Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension

Circulating Microparticles

Inflammation, endothelial dysfunction, and the risk of high blood pressure: epidemiologic and biological evidence

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