High shear granulation of binary mixtures: Effect of powder composition on granule properties

Mangwandi, Chirangano; Liu, Jiangtao; Albadarin, Ahmad B.; Dhenge, Ranjit M.; Walker, Gavin

doi:10.1016/j.powtec.2014.06.021

Cited by 22 publications

(16 citation statements)

References 35 publications

(49 reference statements)

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“…More granules with a size under 3.35 mm were produced when a lower L/S was used. These findings were consistent with the literature, where the granule size was found to be very sensitive to binder to solid ratio [35,36,37]. Higher L/S 0.97 was also tried to make granules, some small lumps were formed during the experiments.…”

Section: Effect Of the Binder To Solid Ratio (L/s) On The Properties supporting

confidence: 91%

Production of solid biofuel granules from drum granulation of bio-waste with silicate-based binders

2019

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Herein compost was selected as a model bio-waste substrate to make solid biofuel granules using wet drum granulation and a sodium silicate binder. Using a laboratoryscale drum granulator (300 g/batch), spherical compost granules within the targeted size range (3.35-14 mm) could be produced with a good compressive strength in good to excellent yields. The effects of compost moisture content, process parameters (drum speed, granulation time) and binder parameters (binder concentration, binder to compost ratio) on the properties of the resulting granules (size distribution, bulk density, compressive strength, water resistance, gross calorific value, ash content) were investigated. The optimal conditions for producing granules as a solid biofuel with competitive properties when compared with woody biomass fuels were achieved by applying a drum rotational speed of 32-37 rpm, granulation time of 15 min, sodium silicate solution 1-3 wt% and binder to solid ratio 0.77-0.90.

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Section: Effect Of the Binder To Solid Ratio (L/s) On The Properties supporting

confidence: 91%

Production of solid biofuel granules from drum granulation of bio-waste with silicate-based binders

2019

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“…Ten tablets were used for each experimental condition to produce reproducible data. The strength of tablets ( σ) was determined by inputting maximum force ( F ), tablet diameter ( D ), and thickness ( T ) in Equation (2) [ 27 , 28 ].

…”

Section: Methodsmentioning

confidence: 99%

Twin Screw Granulation: Effects of Properties of Primary Powders

2018

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Lactose and mannitol are some of the most commonly used powders in the pharmaceutical industry. The limited research published so far highlights the effects of process and formulation parameters on the properties of the granules and the tablets produced using these two types of powders separately. However, the comparison of the performance of these two types of powders during twin screw wet granulation has received no attention. The present research is focused on understanding the granulation mechanism of different grades of two pharmaceutical powders with varying properties (i.e., primary particle size, structure, and compressibility). Three grades each of lactose and mannitol were granulated at varying liquid to solid ratios (L/S) and screw speed. It was noticed that primary powder morphology plays an important role in determining the granule size and structure, and tablet tensile strength. It was indicated that the processed powders such as spray-dried and granulated lactose and mannitol can be used in formulation for wet granulation where flowability of active pharmaceutical ingredient (API) is poor.

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“…The effect of the concentration of the liquid binder is investigated on the contact angle behavior as in the pharmaceutical industry viscosity is a critical parameter as it determines the strength of the liquid bridge between the particles which affects the resultant granule and final tablet properties. The contact angle measurements of the binary mixtures were then measured by a sessile drop method First Ten Angstroms FTA 125 goniometer [19]. The sessile drop method was used to measure the contact angle by using a video camera positioned from the side, adjusting the lighting to obtain good contrast between the droplet and the background [20].…”

Section: ! Experimentsmentioning

confidence: 99%

Wetting of binary powder mixtures

Mundozah

Tridon

Cartwright

et al. 2019

International Journal of Pharmaceutics

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The wetting process involved when a liquid droplet comes into contact with a mixture of particles is a complex phenomenon which is often understood by reference to Cassie-Baxter theory. However, various authors have applied the Cassie-Baxter theory for the prediction of contact angles on two-component mixtures without success. We hypothesise that the main difficulty in applying the Cassie-Baxter theory to mixtures is that if the particles differ in size, it is possible for the small particles to coat the large particles, so reducing the available surface area of the large particles. This leads to the view that bulk volume fractions are not good estimates of surface fractions of the components within the mixture. We argue that the Cassie-Baxter theory over represents the influence of large particles and that below a certain critical volume fraction they exert no influence. We present a simple geometrical model that relates the critical surface coverage volume fraction to the Sauter mean particle size of the binary mixture components. As a consequence, the wetting behaviour can be determined from the bulk volume fractions and the calculated critical surface coverage volume fraction, by means of a simple geometric model. We show that the simple model describes the five two-components systems reported here and a further four systems reported in the literature, irrespective of whether the larger or small particles are hydrophobic/hydrophilic. With this model, it is possible to predict the wetting behaviour of mixtures of particles that coat each other using very simple characterisation methods, so reducing the development time in the creation of formulations in the pharmaceutical industry.

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High shear granulation of binary mixtures: Effect of powder composition on granule properties

Cited by 22 publications

References 35 publications

Production of solid biofuel granules from drum granulation of bio-waste with silicate-based binders

Production of solid biofuel granules from drum granulation of bio-waste with silicate-based binders

Twin Screw Granulation: Effects of Properties of Primary Powders

Wetting of binary powder mixtures

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