High serum YKL-40 level is associated with poor prognosis in patients with lung cancer

Çiledağ, Aydın; Kabalak, Pınar Akın; Çelik, Gökhan; Demir, Nalan; Yüksel, Cabir; Köycü, Gözde; Öztuna, Derya; Rad, Abbas Yousefi; Kaya, Akın; Kutlay, Hakan; Savaş, İsmail; Numanoğlu, Numan

doi:10.5578/tt.67319

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…Özdemir found that YKL-40 may be a predictor of tumour load and metastasis of prostate cancer [ 6 ]. It was reported that YKL-40 could promote the invasion and metastasis of NSCLC by inducing EMT [ 7 ]. The previous study also showed that the increased expression of YKL-40 could promote the invasion and migration of prostate cancer cells [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

YKL-40 promotes invasion and metastasis of bladder cancer by regulating epithelial mesenchymal transition

et al. 2021

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Objective: This study aims to explore the relevance between YKL-40 and recurrence and progression of bladder cancer, and determine whether YKL-40 can be used as a potential target in patients with bladder cancer. Methods: We analyzed the invasion and metastasis ability of BIU-87, UMUC3, J82, T24, 5637 and immortalized human bladder epithelial cells SVHUC1 by Transwell method. The YKL-40 expression levels in cell lines were analyzed by Western blot and qPCR. Results: The increase of YKL-40 level, especially in tumour group, was related to tumour pathological stage and tumour invasion and metastasis. The cell lines with YKL-40 high expression had stronger invasion and metastasis ability. Overexpression of YKL-40 in SVHUC1 with the lowest YKL-40 expression can enhance the invasion and migration of cells. In T24 cells with YKL-40 high expression, transfection of shRNA plasmid targeting YKL-40 can down regulate the invasion and migration. The expression levels of N-cadherin and Vimentin in YKL-40 overexpressed SVHUC1 cells were increased, the E-cadherin expression was decreased, the Twist, Snail and Slug expression levels were increased, but they were opposite in T24 cells with down-regulation of YKL-40 expression. Conclusions: YKL-40 promoted the migration and invasion of bladder cancer cells by up regulating the EMT gene expression. The YKL-40 expression is closely related to the invasion and migration of bladder cancer.

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Section: Introductionmentioning

confidence: 99%

YKL-40 promotes invasion and metastasis of bladder cancer by regulating epithelial mesenchymal transition

et al. 2021

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“…Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder characterized by a persistent airflow limitation and chronic inflammation. Previous studies investigating the correlation between CHI3L1 (YKL40) expression levels and COPD progression have reported elevated levels of CHI3L1 (YKL40) in the blood, sputum, and lung tissue of individuals with COPD compared to healthy individuals or those with other respiratory conditions [ 30 , 31 , 32 , 33 , 34 ]. Moreover, Matsuura et al also reported that higher CHI3L1 (YKL40) levels were associated with more severe COPD phenotypes, including a decline in lung function and emphysema severity, and an increased risk of acute exacerbations [ 35 ].…”

Section: Pathological Roles Of Chi3l1 (Ykl40)mentioning

confidence: 99%

The Role of Chitinase-3-like Protein-1 (YKL40) in the Therapy of Cancer and Other Chronic-Inflammation-Related Diseases

Chang,

Chen,

Chiang

et al. 2024

Pharmaceuticals

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Chitinase-3-like protein-1 (CHI3L1), also known as YKL40, is a glycoprotein that belongs to the chitinase protein family. It is involved in various biological functions, including cell proliferation and tissue remodeling, with inflammatory and immunomodulatory capabilities. Several studies have shown that CHI3L1(YKL40) is upregulated in various diseases, such as cancer, asthma, and inflammatory bowel disease, among others. Although the expression level of CHI3L1(YKL40) is associated with disease activity, severity, and prognosis, its potential as a therapeutic target is still under investigation. In this review, we summarize the biological functions, pathological roles, and potential clinical applications of specific inhibitors and targeted therapies related to CHI3L1(YKL40).

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Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer

Yu,

Yeo,

Han

et al. 2024

Exp Mol Med

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Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is strongly upregulated by various inflammatory and immunological diseases, including several cancers, Alzheimer’s disease, and atherosclerosis. Several studies have shown that CHI3L1 can be considered as a marker of disease diagnosis, prognosis, disease activity, and severity. In addition, the proinflammatory action of CHI3L1 may be mediated via responses to various proinflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, interleukin-6, and interferon-γ. Therefore, CHI3L1 may contribute to a vast array of inflammatory diseases. However, its pathophysiological and pharmacological roles in the development of inflammatory diseases remain unclear. In this article, we review recent findings regarding the roles of CHI3L1 in the development of inflammatory diseases and suggest therapeutic approaches that target CHI3L1.

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High serum YKL-40 level is associated with poor prognosis in patients with lung cancer

Cited by 5 publications

References 9 publications

YKL-40 promotes invasion and metastasis of bladder cancer by regulating epithelial mesenchymal transition

YKL-40 promotes invasion and metastasis of bladder cancer by regulating epithelial mesenchymal transition

The Role of Chitinase-3-like Protein-1 (YKL40) in the Therapy of Cancer and Other Chronic-Inflammation-Related Diseases

Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer

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