High serum transforming growth factor beta 1 (TGFB1) level predicts better survival in breast cancer

Çiftçi, Rümeysa; Taş, Faruk; Yasasever, Ceren Tilgen; Aksit, Ece; Karabulut, Senem; Şen, Fatma; Keskın, Serkan; Kılıç, Leyla; Yıldız, İbrahim; Bozbey, Hamza Ugur; Duranyıldız, Derya; Vatansever, Sezai

doi:10.1007/s13277-014-1932-y

Cited by 18 publications

(22 citation statements)

References 31 publications

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“…In breast cancer patients, mRNA levels of TGF-b, IL-10 and Foxp3 were significantly higher than in healthy controls, which was consistent with previous studies (7,15,49,50). We also found that mRNA levels of IL-10 were higher in stage IV breast cancer patients, with a strong trend, but there was no correlation between other tumor characteristics, possibly because of the limited number of patients.…”

Section: Discussionsupporting

confidence: 91%

Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients

et al. 2018

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Transforming growth factor-β (TGF-β), interleukin-10 (IL-10), and forkhead box P3 (Foxp3) have important roles in breast cancer development. Previous studies confirmed a correlation between these immune molecules and tumor characteristics, but their association with nutritional status in breast cancer is largely unknown. We aimed to investigate the association between body mass index (BMI), hemoglobin, total protein, albumin, globulin (GLB), albumin/GLB ratio (AGR), pre-albumin, prognostic nutritional index, and TGF-β, IL-10, and Foxp3 mRNA expression in patients with breast cancer. Quantitative real-time PCR was used to detect the mRNA expression of TGF-β, IL-10, and Foxp3 in the peripheral blood of 107 patients with breast cancer and 21 healthy controls. We found that TGF-β mRNA levels were 2.6-fold, 3.2-fold, and 2.3-fold higher in patients with low BMI (<23), low AGR, and high GLB, respectively, than in their counterparts (P < 0.05). In addition, IL-10 mRNA expression levels in patients with normal BMI (<23) were 2.8-fold and 3.5-fold higher than in those who were overweight (23≤ BMI <25) and obese (BMI ≥ 25), respectively (P < 0.05). In addition, TGF-β, IL-10, and Foxp3 mRNA levels were significantly higher in patients with breast cancer than in healthy controls (P < 0.05). In summary, our results suggest that nutritional status, especially BMI, may strongly affect systematic immune function in patients with breast cancer. © 2018 IUBMB Life, 70(3):237-245, 2018.

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Section: Discussionsupporting

confidence: 91%

Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients

et al. 2018

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“…Prognostic impact of plasma levels is therefore controversial [34–38]. In this patient cohort we observed a significant negative correlation of pre-therapeutic TGFβ1 with overall survival.…”

Section: Discussionmentioning

confidence: 80%

Perioperative changes in osteopontin and TGFβ1 plasma levels and their prognostic impact for radiotherapy in head and neck cancer

et al. 2017

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BackgroundIn head and neck cancer little is known about the kinetics of osteopontin (OPN) expression after tumor resection. In this study we evaluated the time course of OPN plasma levels before and after surgery.MethodsBetween 2011 and 2013 41 consecutive head and neck cancer patients were enrolled in a prospective study (group A). At different time points plasma samples were collected: T0) before, T1) 1 day, T2) 1 week and T3) 4 weeks after surgery. Osteopontin and TGFβ1 plasma concentrations were measured with a commercial ELISA system. Data were compared to 131 head and neck cancer patients treated with primary (n = 42) or postoperative radiotherapy (n = 89; group B1 and B2).ResultsA significant OPN increase was seen as early as 1 day after surgery (T0 to T1, p < 0.01). OPN levels decreased to base line 3-4 weeks after surgery. OPN values were correlated with postoperative TGFβ1 expression suggesting a relation to wound healing. Survival analysis showed a significant benefit for patients with lower OPN levels both in the primary and postoperative radiotherapy group (B1: 33 vs 11.5 months, p = 0.017, B2: median not reached vs 33.4, p = 0.031). TGFβ1 was also of prognostic significance in group B1 (33.0 vs 10.7 months, p = 0.003).ConclusionsPatients with head and neck cancer showed an increase in osteopontin plasma levels directly after surgery. Four weeks later OPN concentration decreased to pre-surgery levels. This long lasting increase was presumably associated to wound healing. Both pretherapeutic osteopontin and TGFβ1 had prognostic impact.

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“…ICAM-1 is a transmembrane glycoprotein in the immunoglobulin superfamily, which participates in oral cancer progression and induces macrophage/SCC-cell adhesion [ 13 ]. Ciftci et al [ 14 ] indicated that serum TGFB1 level might be elevated in breast cancer patients and had a favorable prognostic value. CDH1, involved in cell adhesion, can code the adhesion protein E-cadherin that plays a central part in the process of epithelial morphogenesis [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Molecular Mechanism and Biomakers of Liver Cancer Based on Gene Expression Microarray

Liu

Jiang

Ren

et al. 2015

Pathol. Oncol. Res.

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Liver cancer is one of the most common cancers worldwide with high morbidity and mortality. Its molecular mechanism hasn’t been fully understood though many studies have been conducted and thus further researches are still needed to improve the prognosis of liver cancer. Firstly, differentially expressed genes (DEGs) between six Mdr2-knockout (Mdr2-KO) mutant mice samples (3-month-old and 12-month-old) and six control mice samples were identified. Then, the enriched GO terms and KEGG pathways of those DEGs were obtained using the Database for Annotation, Visualization and Integrated Discovery (DAVID, http://david.abcc.ncifcrf.gov/). Finally, protein-protein interactions (PPI) network of those DEGs were constructed using STRING database (http://www.string-db.org/) and visualized by Cytoscape software, at the same time, genes with high degree were selected out. Several novel biomarkers that might play important roles in liver cancer were identified through the analysis of gene microarray in GEO. Also, some genes such as Tyrobp, Ctss and pathways such as Pathways in cancer, ECM-receptor interaction that had been researched previously were further confirmed in this study. Through the bioinformatics analysis of the gene microarray in GEO, we found some novel biomarkers of liver cancer and further confirmed some known biomarkers.

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High serum transforming growth factor beta 1 (TGFB1) level predicts better survival in breast cancer

Cited by 18 publications

References 31 publications

Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients

Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients

Perioperative changes in osteopontin and TGFβ1 plasma levels and their prognostic impact for radiotherapy in head and neck cancer

Exploring the Molecular Mechanism and Biomakers of Liver Cancer Based on Gene Expression Microarray

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