High serum testosterone levels during postpartum period are associated with postpartum depression

Aswathi, Anand; Rajendiren, Soundravally; Nimesh, Archana; Philip, RiaAnn; Kattimani, Shivanand; Durairaj, Jayalakshmi; Ananthanarayanan, Palghat Hariharan; Dhiman, Pooja

doi:10.1016/j.ajp.2015.08.008

Cited by 34 publications

(21 citation statements)

References 20 publications

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“…The peripartum period is characterized by rapid and significant physiological change in plasma levels of endocrine hormones, peptides and neuroactive steroids (NAS) [123][124][125][126][127][128]. Several lines of research are actively examining the potential roles of cortisol [112,113,[129][130][131][132], corticotropin-releasing hormone (CRH) [106,[133][134][135][136], adrenocorticotropic hormone (ACTH) [137,138] oxytocin [139][140][141], prolactin [142,143], testosterone [144][145][146], NAS [121,147], and thyroid function [148][149][150][151] in PPD.…”

Section: Current Understanding Of the Neurobiology Of Postpartum Deprmentioning

confidence: 99%

Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development

et al. 2019

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Postpartum depression is one of the most common complications of childbirth. Untreated postpartum depression can have substantial adverse effects on the well-being of the mother and child, negatively impacting child cognitive, behavioral, and emotional development with lasting consequences. There are a number of therapeutic interventions for postpartum depression including pharmacotherapy, psychotherapy, neuromodulation and hormonal therapy among others, most of which have been adapted from the treatment of major depressive disorder outside of the peripartum period. Current evidence of antidepressant treatment for postpartum depression is limited by the small number of randomized clinical trials, underpowered samples and lack of longterm follow-up. The peripartum period is characterized by rapid and significant physiological change in plasma levels of endocrine hormones, peptides and neuroactive steroids. Evidence supporting the role of neuroactive steroids and GABA in the pathophysiology of postpartum depression led to the investigation of synthetic neuroactive steroids and their analogs as potential treatment for postpartum depression. Brexanolone, a soluble, proprietary, intravenous preparation of synthetic allopregnanolone has been developed. A recent series of open-label and placebocontrolled randomized clinical trials of brexanolone in postpartum depression demonstrated rapid reduction of depressive symptoms, and have led to the submission for regulatory approval to the US Food and Drug Administration (decision due in March 2019). SAGE-217, an allopregnanolone analog, with oral bioavailability, was recently tested in a randomized, double-blind, placebocontrolled phase 3 study in severe postpartum depression, with reportedly positive results. Finally,

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Section: Current Understanding Of the Neurobiology Of Postpartum Deprmentioning

confidence: 99%

Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development

et al. 2019

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“…Another study found that testosterone levels correlated positively with depression and anger scale scores at 38 -40 weeks gestation [68]. Four studies found a positive correlation with postpartum testosterone levels and concurrent depression scores [63,[68][69][70] In studies of men and women (outside of the puerperium) there were opposite findingsmost studies found that low levels of testosterone correlate with depressive and anxiety symptoms and that treatment of these disorders with SSRIs results in restoration of levels [71]. This opposing finding to results in perinatal depression is yet another illustration of how poorly we understand the exact mechanism of action of these NASs in reproductiverelated depressions.…”

Section: Testosteronementioning

confidence: 98%

Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature

McEvoy

Payne

Osborne

2018

Curr Psychiatry Rep

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The bulk of the evidence on neuroactive steroids in perinatal depression concerns allopregnanolone. Recent studies have been mixed, with some studies finding a direct correlation between lower levels of allopregnanolone and increased depressive symptoms but other studies finding no relationship. Evidence concerning other neuroactive steroids and perinatal depression is sparse. Additional research is needed with larger sample sizes and better characterization across the perinatal period (rather than cross-sectionally). Because some studies point to a lag between neuroactive steroid dysregulation and subsequent symptoms, future research should consider interactions with other aspects of neuroactive steroid physiology, such as synthetic enzymes or receptor plasticity.

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“…Postpartum depression is the most common psychological disorder in the 1 st year after childbirth. [ 1 ] It is characterized by mood swings, appetite changes, excessive sadness, death thoughts and suicide,[ 2 3 ] reduction of the quality of life,[ 4 ] difficulties in mother and infant's attachment,[ 5 ] and reduction on the cognitive aspects of the child. [ 6 ] The role of biological agents and hormonal fluctuations on this disorder has already been described.…”

Section: Introductionmentioning

confidence: 99%

Examining the relationship between mothers' prenatal mental health and demographic factors with postpartum depression

Ghaedrahmati

Kazemi

Kheirabadi

et al. 2018

J Edu Health Promot

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High serum testosterone levels during postpartum period are associated with postpartum depression

Cited by 34 publications

References 20 publications

Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development

Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development

Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature

Examining the relationship between mothers' prenatal mental health and demographic factors with postpartum depression

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