High serum magnesium levels are associated with favorable prognoses in diabetic hemodialysis patients, retrospective observational study

Abstract

Background Recent studies have found hypomagnesemia is linked to a heightened risk of cardiovascular events and mortality in hemodialysis (HD) patients; however, the level of serum magnesium (s-Mg) necessary for promoting overall health in these patients and the effects of s-Mg in diabetes HD patients remains to be clarified. Methods HD outpatients (n = 148 under, age � 70 y) were followed over a 6-y period. They were divided into four groups according to their average s-Mg during the first year (L; low level, H; high level) and if they had DM or not (non-DM). The endpoint was mortality and hospitalization for decline of Activities of Daily Living (death/hospitalization). A receiver operating characteristics curve was used in diagnostic tests to identify s-Mg associated with this endpoint. Kaplan-Meier, log-rank test, and a Cox proportional hazards model were used to evaluate prognoses. Fisher's exact test and multiple regressions examined the causes of the endpoints between the four groups and the factors predictive of s-Mg.

Associations between the serum magnesium and all-cause or cardiovascular mortality in chronic kidney disease and end-stage renal disease patients

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“…de Francisco et al [37] 2017 Spain 2242 68.1 6 mo Retrospective HD All-cause mortality 7 Zhang et al [38] 2017 China 92 73.92 ± 10.73 5 yrs Retrospective HD All-cause mortality 7 Ye et al [39] 2018 China 402 49.3 ± 14.9 49.9 mo Prospective PD All-cause and cardiovascular mortality 7 Li et al [40] 2019 China 446 53.52 ± 15.21 3 yrs Retrospective HD All-cause and cardiovascular mortality 6 Lu et al [41] 2019 China 413 50.4 ± 14.3 12 mo Retrospective HD All-cause and cardiovascular mortality 6 Mizuiri et al [42] 2019 Japan 215 73 3 yrs Retrospective HD All-cause mortality 6 Wu et al [43] 2019 China 169 60.20 ± 15.64 37 mo Prospective HD All-cause and cardiovascular mortality 7 Ogawa et al [44] 2020 Japan 148 56.4 ± 10.5 6 yrs Prospective HD All-cause mortality 7 Guan et al [45] 2020 China 381 56.1 ± 14.2 6.5 yrs Prospective PD All-cause and cardiovascular mortality 7 CKD = chronic kidney disease, HD = hemodialysis, N = number, NOS = Newcastle-Ottawa Scale, PD = peritoneal dialysis.…”