High serum levels of procollagen type III N-terminal amino peptide in patients with congenital heart disease

Sugimoto, Masaya; Masutani, Satoshi; Seki, Mitsuru; Kajino, Hiroki; Fujieda, Kenji; Senzaki, Hideaki

doi:10.1136/hrt.2009.170241

Cited by 27 publications

(15 citation statements)

References 43 publications

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“…[22] In a previous study by our group, the PIIIP level was found to be elevated owing to various hemodynamics in children with CHD. [23] In children with VSDs or ASDs exhibiting ventricular volume overload, the PIIIP level was found to correlate with the pulmonary-to-systemic blood flow ratio (Qp/Qs), whereas in children with Tetralogy of Fallot (TOF), the PIIIP level was found to correlate with the degree of cyanosis. Moreover, we also found that the PIIIP levels were inhibited by angiotensin-converting enzyme inhibitors.…”

Section: Biomarker Of Myocardial Fi Brosis and Interstitial Remodelinmentioning

confidence: 97%

Cardiac biomarkers in children with congenital heart disease

et al. 2015

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Section: Biomarker Of Myocardial Fi Brosis and Interstitial Remodelinmentioning

confidence: 97%

Cardiac biomarkers in children with congenital heart disease

et al. 2015

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“…43 Myocardial cells are finally differentiated cells and do not have the potential to divide. In addition, the reproduction of myocardial cells from stem cells and progenitor cells is extremely limited.…”

Section: Discussionmentioning

confidence: 99%

Volume Overload and Pressure Overload due to Left-to-Right Shunt-Induced Myocardial Injury - Evaluation Using a Highly Sensitive Cardiac Troponin-I Assay in Children With Congenital Heart Disease -

Sugimoto

Ota

Kajihama

et al. 2011

Circ J

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Background: Cardiac troponin I (cTnI) is currently considered to be the most sensitive and specific biochemical marker of acute coronary syndrome and acute myocardial infarction. However, few reports have described the use of cTnI assays for evaluating abnormal hemodynamic load in children with congenital heart disease (CHD). It was hypothesized that significant hemodynamic overload due to a left-to-right shunt induces myocardial injury. Methods and Results:A highly sensitive cTnI assay was used to measure the serum cTnI levels in 30 children with atrial septal defect (ASD), 32 children with ventricular septal defect (VSD), and 350 healthy children. Cardiac catheterization was performed in the children with ASD and VSD to determine the ratio of pulmonary to systemic blood flow, the ratio of pulmonary to systemic arterial pressure (Pp/Ps), the pulmonary vascular resistance index, and the right and left ventricular end-diastolic volume. Serum cTnI levels in both the ASD and VSD children were significantly higher than those in healthy children (P<0.05 and P<0.01, respectively). Furthermore, serum cTnI levels significantly correlated with Pp/Ps (r=0.745, P<0.001) in VSD children.Conclusions: Significant volume and pressure overload due to a left-to-right shunt induce myocardial injury and might eventually cause irreversible myocardial remodeling in children with CHD. The serum cTnI level is a useful biomarker for evaluating myocardial damage associated with pulmonary hypertension in VSD children. (Circ J 2011; 75: 2213 - 2219

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“…AUROC, area under the receiver operating characteristic curve; CHB, chronic hepatitis B. AUROC of the noninvasive model >0.800 (in bold) 37. and its serum levels are elevated in various pathologic disorders, such as viral and nonviral liver disease,38 congenital heart disease,39 chronic kidney disease40 and systemic sclerosis 41. Many noninvasive models for assessing liver fibrosis obtained commendable performance by combining PIIINP and other serum markers 27,38.…”

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confidence: 99%

Evaluation and comparison of thirty noninvasive models for diagnosing liver fibrosis in chinese hepatitis B patients

Dong

Zhao

et al. 2018

Journal of Viral Hepatitis

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The limitations of liver biopsy have led to the development of indirect noninvasive models for liver fibrosis assessment. We aimed to evaluate and compare the performance of 30 noninvasive models to predict fibrosis stage in treatment‐naïve and treated chronic hepatitis B (CHB) patients. A total of 576 Chinese treatment‐naïve CHB patients and 236 treated CHB patients who had undergone percutaneous liver biopsy were included in the analysis. Histological grading and staging was assessed by the Ishak scoring system. The diagnostic accuracies of 30 noninvasive models were assessed by area under the receiver operating characteristic curves (AUROCs). In treatment‐naïve CHB patients, the AUROCs of the 30 noninvasive models for discriminating significant fibrosis (SF) were less than 0.800, and only the AUROC of the PP score for diagnosing advanced fibrosis (AF) was more than 0.800, while the AUROCs of FIB‐4, FibroQ, HB‐F, Lok index, PHP score and PP score for predicting cirrhosis were greater than 0.800. In treated CHB patients, only the AUROCs of APRI, GUCI, King's score and Wang I for identifying cirrhosis were more than 0.800. The Spearman correlation analysis identified that only the changes in FCI and Virahep‐C model values were weakly correlated with changes in Ishak fibrosis scores before and after treatment (r = 0.206, p = 0.008; r = 0.187, p = 0.016, respectively). In conclusion, in Chinese CHB patients, the 30 existing noninvasive models were not suitable for assessing each stage of fibrosis except cirrhosis before and after antiviral therapy, especially in gauging progression and regression of liver fibrosis following therapy.

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High serum levels of procollagen type III N-terminal amino peptide in patients with congenital heart disease

Cited by 27 publications

References 43 publications

Cardiac biomarkers in children with congenital heart disease

Cardiac biomarkers in children with congenital heart disease

Volume Overload and Pressure Overload due to Left-to-Right Shunt-Induced Myocardial Injury - Evaluation Using a Highly Sensitive Cardiac Troponin-I Assay in Children With Congenital Heart Disease -

Evaluation and comparison of thirty noninvasive models for diagnosing liver fibrosis in chinese hepatitis B patients

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