High Serum Levels of High-Mobility Group Box 1 (HMGB1) and Low Levels of Heat Shock Protein 70 (Hsp70) are Associated with Poor Prognosis in Patients with Acute Pancreatitis

Arriaga-Pizano, Lourdes; Boscó-Gárate, Ilka; Martínez-Ordaz, José Luis; Wong‐Baeza, Isabel; Gutiérrez-Mendoza, Mireille; Sánchez-Fernández, Patricio; López-Macías, Constantino; Isibasí, Armando; Peláez-Luna, Mario; Cérbulo-Vázquez, Arturo; Torres-González, R; Ferat‐Osorio, Eduardo

doi:10.1016/j.arcmed.2019.02.003

Cited by 20 publications

(24 citation statements)

References 47 publications

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“…Nonetheless, as described so far, the anti‐HMGB1‐neutralizing antibody and TMα strongly prevent visceral pain, rather than inflammation itself, suggesting that HMGB1 is more important in the development of pain than inflammation. Excessive release of HMGB1 in relatively more severe visceral inflammation models contributes more to the development of inflammation and the anti‐HMGB1‐neutralizing antibody more potently inhibit visceral inflammation (G. Li et al, 2016; Shen & Li, 2015; Yu et al, 2016; T. Zhang, Xia, et al, 2015), in agreement with clinical reports (Arriaga‐Pizano et al, 2018; Yasuda et al, 2006). There is much evidence for involvement of HMGB1 in inflammatory bowel diseases (IBD).…”

Section: A Role Of Hmgb1 In Pain Processingsupporting

confidence: 78%

“…Patients with pancreatitis or pancreatic cancer frequently experience severe pancreatic pain that has nociceptive, inflammatory and neuropathic components of pain (Nechutova et al, 2014). Clinical reports have shown that serum HMGB1 levels increase in patients with severe acute pancreatitis and are correlated with severity or poor prognosis of pancreatitis (Arriaga‐Pizano et al, 2018; Yasuda et al, 2006). Similarly, preclinical studies have demonstrated that HMGB1 levels in the serum or pancreatic tissue slowly increase with the development of severe acute pancreatitis by i.p.…”

Section: A Role Of Hmgb1 In Pain Processingmentioning

confidence: 99%

“…Pain or hyperalgesia/allodynia caused by exogenously applied HMGB1 sensory nerves (Aromolaran & Goldstein, 2017;Flatters, Dougherty, & Colvin, 2017;Tomita et al, 2019). A series of our preclinical studies have shown the critical role of endogenous HMGB1 in the development of CIPN on the basis of findings that an anti-HMGB1-neutralizing antibody and TMα, capable of degrading HMGB1 in a thrombin-dependent manner (Figure 1c), completely prevented the CIPN in the mice or rats treated with different chemotherapeutic agents including paclitaxel, vincristine and oxaliplatin (Nishida et al, 2016;Sekiguchi et al, 2018;Tsubota et al, 2019; Li et al, 2014;Sekiguchi et al, 2018; Figure 2).…”

Section: Chemotherapy-induced Peripheral Neuropathymentioning

confidence: 99%

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Role of high‐mobility group box 1 and its modulation by thrombomodulin/thrombin axis in neuropathic and inflammatory pain

Tsujita

Tsubota

Sekiguchi

et al. 2020

British J Pharmacology

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High‐mobility group box 1 (HMGB1), a nuclear protein, once released to the extracellular space, facilitates pain signals as well as inflammation. Intraplantar or intraspinal application of HMGB1 elicits hyperalgesia/allodynia in rodents by activating the advanced glycosylation end‐product specific receptor (receptor for advanced glycation end‐products; RAGE) or Toll‐like receptor 4 (TLR4). Endogenous HMGB1 derived from neurons, perineuronal cells or immune cells accumulating in the dorsal root ganglion or sensory nerves participates in somatic and visceral pain consisting of neuropathic and/or inflammatory components. Endothelial thrombomodulin (TM) and recombinant human soluble TM, TMα, markedly increase thrombin‐dependent degradation of HMGB1, and systemic administration of TMα prevents and reverses various HMGB1‐dependent pathological pain. Low MW compounds that directly inactivate HMGB1 or antagonize HMGB1‐targeted receptors would be useful to reduce various forms of intractable pain. Thus, HMGB1 and its receptors are considered to serve as promising targets in developing novel agents to prevent or treat pathological pain. LINKED ARTICLES This article is part of a themed issue on Neurochemistry in Japan. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.4/issuetoc

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Section: A Role Of Hmgb1 In Pain Processingsupporting

confidence: 78%

Section: A Role Of Hmgb1 In Pain Processingmentioning

confidence: 99%

Section: Chemotherapy-induced Peripheral Neuropathymentioning

confidence: 99%

See 1 more Smart Citation

Role of high‐mobility group box 1 and its modulation by thrombomodulin/thrombin axis in neuropathic and inflammatory pain

Tsujita

Tsubota

Sekiguchi

et al. 2020

British J Pharmacology

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“…High-motility group box protein 1 (HMGB1) is recognized as an important predictor for the persistence and further development of pancreatitis (Arriaga-Pizano et al., 2018 ). HMGB-1 is an advanced inflammatory factor that is usually produced in the late stage of inflammation and keep at a high level for a while, which is different from TNF-a, IL-6, and other inflammatory factors.…”

Section: Molecular and Cellular Mechanisms Of Acute Pancreatitismentioning

confidence: 99%

Drug discovery and formulation development for acute pancreatitis

et al. 2020

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Acute pancreatitis is a sudden inflammation and only last for a short time, but might lead to a life-threatening emergency. Traditional drug therapy is an essential supportive method for acute pancreatitis treatment, yet, failed to achieve satisfactory therapeutic outcomes. To date, it is still challenging to develop therapeutic medicine to redress the intricate microenvironment promptly in the inflamed pancreas, and more importantly, avoid multi-organ failure. The understanding of the acute pancreatitis, including the causes, mechanism, and severity judgment, could help the scientists bring up more effective intervention and treatment strategies. New formulation approaches have been investigated to precisely deliver therapeutics to inflammatory lesions in the pancreas, and some even could directly attenuate the pancreatic damages. In this review, we will briefly introduce the involved pathogenesis and underlying mechanisms of acute pancreatitis, as well as the traditional Chinese medicine and the new drug option. Most of all, we will summarize the drug delivery strategies to reduce inflammation and potentially prevent the further development of pancreatitis, with an emphasis on the bifunctional nanoparticles that act as both drug delivery carriers and therapeutics.

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“…Another method wherein HSP70 played a crucial role in regulating inflammation response was the inhibition of the secretion of HMGB1. During the acute phase of acute pancreatitis, cell damage led to the release of cytokines, HMGB1 and HSP70 [11]. It was reported that HSP70 might play a protective role in AP since its decrease in concentration was associated with poor pancreatitis outcome, severity, and higher mortality.…”

Section: Introductionmentioning

confidence: 99%

Tethered Lipid Membranes as a Nanoscale Arrangement towards Non-Invasive Analysis of Acute Pancreatitis

et al. 2021

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Extracellular heat shock proteins (HSPs) mediate immunological functions and are involved in pathologies such as infection, stress, and cancer. Here, we demonstrated the dependence of an amount of HSP70 and HSP90 in serum vs. severity of acute pancreatitis (AP) on a cohort of 49 patients. Tethered bilayer lipid membranes (tBLMs) have been developed to investigate HSPs’ interactions with tBLMs that can be probed by electrochemical impedance spectroscopy (EIS). The results revealed that HSP70 and HSP90 interact via different mechanisms. HSP70 shows the damage of the membrane, while HSP90 increases the insulation properties of tBLM. These findings provide evidence that EIS offers a novel approach for the study of the changes in membrane integrity induced by HSPs proteins. Herein, we present an alternative electrochemical technique, without any immunoprobes, that allows for the monitoring of HSPs on nanoscaled tBLM arrangement in biologics samples such us human urine. This study demonstrates the great potential of tBLM to be used as a membrane based biosensor for novel, simple, and non-invasive label-free analytical system for the prediction of AP severity.

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High Serum Levels of High-Mobility Group Box 1 (HMGB1) and Low Levels of Heat Shock Protein 70 (Hsp70) are Associated with Poor Prognosis in Patients with Acute Pancreatitis

Cited by 20 publications

References 47 publications

Role of high‐mobility group box 1 and its modulation by thrombomodulin/thrombin axis in neuropathic and inflammatory pain

Role of high‐mobility group box 1 and its modulation by thrombomodulin/thrombin axis in neuropathic and inflammatory pain

Drug discovery and formulation development for acute pancreatitis

Tethered Lipid Membranes as a Nanoscale Arrangement towards Non-Invasive Analysis of Acute Pancreatitis

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