High serum levels of beta subunit human chorionic gonadotropin in trisomy X

Elevated maternal serum human chorionic gonadotropin associated with a chromosomal deletion

“…Maternal serum human chorionic gonadotropin (MShCG) has recently been introduced as a screening procedure for the detection of fetal trisomy 21, where the MShCG level is frequently, but not always, elevated. We read with interest the two letters to the editor reported in yourjournal (Barkai et al, 1991;Ben-Neriah et al, 1992) correlating increased MShCG also with sex chromosome abnormalities. In this regard, we wish to report a case of elevated MShCG associated with a chromosome deletion.…”

Elevated maternal serum alpha‐fetoprotein, very low unconjugated oestriol, and very low human chorionic gonadotropin associated with recent fetal death

“…Biochemical screening for fetal Down syndrome now includes measurement of maternal serum unconjugated oestriol (MSuE3) and maternal serum human chorionic gonadotropin (MShCG), in addition to MSAFP in com-bination with maternal age (Wald et al, 1988). Patterns of these biochemical markers in pregnancies associated with other fetal defects (Canick et al, 1990a;Zalel et al, 1992) and aneuploidies (Canick et al, 1990b;Ben-Neriah et al, 1991;Barkai et al, 1991;Oyer and Canick, 1992) revealed a normally-formed dead fetus of approximately 12 weeks fetal age. We reviewed results from the approximately 3000 women screened by the Vermont Prenatal Screening Program since we began measuring the three markers in February 1992.…”