High Serum Level of Pentosidine, an Advanced Glycation End Product (AGE), is a Risk Factor of Patients with Heart Failure

Koyama, Yo; Takeishi, Yasuchika; Arimoto, Takanori; Niizeki, Takeshi; Shishido, Tetsuro; Takahashi, Hitomi; Nakatani, Naoki; Hirono, Osamu; Tsunoda, Yuichi; Nitobe, Joji; Watanabe, Tetsu; Kubota, Isao

doi:10.1016/j.cardfail.2006.11.009

Cited by 118 publications

(89 citation statements)

References 35 publications

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“…In support of this suggestion, an association has been shown between AGE accumulation measured as skin AF and peripheral arterial disease independent of diabetes status, and increasing AGEs (measured as serum pentosidine) have been associated with poor prognosis in people with heart failure (29,30). In the context of CKD, Hartog et al (16) showed correlation between skin AF and poorer diastolic function in a crosssectional study of peritoneal dialysis and hemodialysis patients, and Meerwaldt et al (20) identified independent associations between skin AF and cardiovascular as well as all-cause mortality in a prospective cohort of 109 patients on hemodialysis.…”

Section: Discussionmentioning

confidence: 91%

Skin Autofluorescence and All-Cause Mortality in Stage 3 CKD

Fraser

Roderick

McIntyre

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Novel markers may help to improve risk prediction in CKD. One potential candidate is tissue advanced glycation end product accumulation, a marker of cumulative metabolic stress, which can be assessed by a simple noninvasive measurement of skin autofluorescence. Skin autofluorescence correlates with higher risk of cardiovascular events and mortality in people with diabetes or people requiring RRT, but its role in earlier CKD has not been studied.Design, setting, participants, & measurements A prospective cohort of 1741 people with CKD stage 3 was recruited from primary care between August 2008 and March 2010. Participants underwent medical history, clinical assessment, blood and urine sampling for biochemistry, and measurement of skin autofluorescence. Kaplan-Meier plots and multivariate Cox proportional hazards models were used to investigate associations between skin autofluorescence (categorical in quartiles) and all-cause mortality.Results In total, 1707 participants had skin autofluorescence measured; 170 (10%) participants died after a median of 3.6 years of follow-up. The most common cause of death was cardiovascular disease (41%). Higher skin autofluorescence was associated significantly with poorer survival (all-cause mortality, P,0.001) on KaplanMeier analysis. Univariate and age/sex-adjusted Cox proportional hazards models showed that the highest quartile of skin autofluorescence was associated with all-cause mortality (hazard ratio, 2.64; 95% confidence interval, 1.71 to 4.08; P,0.001 and hazard ratio, 1.84; 95% confidence interval, 1.18 to 2.86; P=0.003, respectively, compared with the lowest quartile). This association was not maintained after additional adjustment to include cardiovascular disease, diabetes, smoking, body mass index, eGFR, albuminuria, and hemoglobin.Conclusions Skin autofluorescence was not independently associated with all-cause mortality in this study. Additional research is needed to clarify whether it has a role in risk prediction in CKD.

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Section: Discussionmentioning

confidence: 91%

Skin Autofluorescence and All-Cause Mortality in Stage 3 CKD

Fraser

Roderick

McIntyre

et al. 2014

Clinical Journal of the American Society of Nephrology

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“…Serum AGE levels have been demonstrated as independent predictors of both the severity and prognosis in heart failure patients [14,55] . Plasma pentosidine levels, one of the crosslinking AGEs, has been shown to be an independent predictor of both re-hospitalization and mortality in heart failure patients independent from other known risk factors such as brain natriuretic peptide (BNP), age, renal function and New York Heart Association (NYHA) functional class [55] .…”

Section: Complications Of Diabetesmentioning

confidence: 99%

“…Plasma pentosidine levels, one of the crosslinking AGEs, has been shown to be an independent predictor of both re-hospitalization and mortality in heart failure patients independent from other known risk factors such as brain natriuretic peptide (BNP), age, renal function and New York Heart Association (NYHA) functional class [55] . Similarly, plasma levels of N-CML, one of the most prevalent antigenic AGEs in sera of diabetic patients, have been shown to correlate with NYHA functional class and predict outcomes in patients with systolic heart failure [14] .…”

Section: Complications Of Diabetesmentioning

confidence: 99%

Role of advanced glycation end products in cardiovascular disease

Hegab

Gibbons²,

Neyses

et al. 2012

WJC

276

193

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Advanced glycation end products (AGEs) are produced through the non enzymatic glycation and oxidation of proteins, lipids and nucleic acids. Enhanced formation of AGEs occurs particularly in conditions associated with hyperglycaemia such as diabetes mellitus (DM). AGEs are believed to have a key role in the development and progression of cardiovascular disease in patients with DM through the modification of the structure, function and mechanical properties of tissues through crosslinking intracellular as well as extracellular matrix proteins and through modulating cellular processes through binding to cell surface receptors [receptor for AGEs (RAGE)]. A number of studies have shown a correlation between serum AGE levels and the development and severity of heart failure (HF). Moreover, some studies have suggested that therapies targeted against AGEs may have therapeutic potential in patients with HF. The purpose of this review is to discuss the role of AGEs in cardiovascular disease and in particular in heart failure, focussing on both cellular mechanisms of action as well as highlighting how targeting AGEs may represent a novel therapeutic strategy in the treatment of HF.

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“…However, it was reported that a higher pentosidine concentration was related to a poor outcome of cerebral infarction [22] and cardiac events [20,23], indicating the possibility that pentosidine might play pathophysiological roles, such as induction of oxidative stress and endothelial dysfunction [24,25], in the progression of cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%