High Serum Fractalkine is Associated with Lower Trabecular Bone Score in Premenopausal Women with Graves’ Disease

Kužma, Martin; Vaňuga, Peter; Binkley, Neil; Ságová, Ivana; Pávai, Dušan; Blazícek, P; Kužmová, Zuzana; Jackuliak, Peter; Vaňuga, Anton; Killinger, Zdenko; Payer, Juraj

doi:10.1055/a-0633-2814

Cited by 16 publications

(11 citation statements)

References 25 publications

(32 reference statements)

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“…No association was shown between lumbar BMD and thyroid hormones levels, whereas high-normal FT4 levels were negatively correlated with TBS in postmenopausal women (44). Very recently, Kuzma et al showed a lower TBS value in 21 premenopausal women with untreated Graves' disease compared to healthy controls (45). Among patients given TSH suppressive therapy, different studies showed an impairment of TBS especially in postmenopausal women.…”

Section: Trabecular Bone Score (Tbs) and Quantitative Computed Tomogrmentioning

confidence: 98%

TSH suppressive therapy and bone

Brancatella

Marcocci

2020

Endocrine Connections

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Thyroid hormones stimulate bone turnover in adults by increasing osteoclastic bone resorption. TSH suppressive therapy is usually applied in patients with differentiated thyroid cancer (DTC) to improve the disease outcome. Over the last decades several authors have closely monitored the potential harm suffered by the skeletal system. Several studies and meta-analyses have shown that chronic TSH suppressive therapy is safe in premenopausal women and men. Conversely, in postmenopausal women TSH suppressive therapy is associated with a decrease of bone mineral density, deterioration of bone architecture (quantitative computed tomography, QCT; trabecular bone score, TBS), and, possibly, an increased risk of fractures. The TSH receptor is expressed in bone cells and the results of experimental studies in TSH receptor knockout mice and humans on whether low TSH levels, as opposed to solely high thyroid hormone levels, might contribute to bone loss in endogenous or exogenous thyrotoxicosis remain controversial. Recent guidelines on the use of TSH suppressive therapy in patients with DTC give value not only to its benefit on the outcome of the disease, but also to the risks associated with exogenous thyrotoxicosis, namely menopause, osteopenia or osteoporosis, age > 60 years, and history of atrial fibrillation. Bone health (BMD and/or preferably TBS) should be evaluated in postmenopausal women under chronic TSH suppressive therapy or in those patients planning to be treated for several years. Antiresorptive therapy could also be considered in selected cases (increased risk of fracture or significant decline of BMD/TBS during therapy) to prevent bone loss.

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Section: Trabecular Bone Score (Tbs) and Quantitative Computed Tomogrmentioning

confidence: 98%

TSH suppressive therapy and bone

Brancatella

Marcocci

2020

Endocrine Connections

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“…Other studies based on a group of premenopausal women showed that Graves' Disease is in strong correlation with decreased TBS, whereas the BMD still did not differ between active the Graves' Disease group and the control group [55].…”

Section: Thyroid Diseasesmentioning

confidence: 75%

Trabecular bone score (TBS) as a noninvasive and complementary tool for clinical diagnosis of bone structure in endocrine disorders

Halupczok-Żyła

Bolanowski

2019

Endokrynologia Polska

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Trabecular bone score (TBS) index has recently been obtained as a result of textural greyscale analysis of DXA images. Because it enables the assessment of bone microarchitectural texture, TBS may be useful in evaluating bone quality. This study explores the current knowledge of the use of TBS in patients with endocrine disorders with co-occurring bone structure changes. Currently, the clinical importance TBS was verified in terms of disorders of the growth hormone/insulin-like growth factor 1 (GH/IGF-I) axis, glucocorticoid excess, thyroid and parathyroid disease, as well as in diabetes mellitus type 1 and 2. It has been clarified that patients suffering from various endocrinopathies are a group in which TBS should be used routinely because it correlates with clinical factors and may improve patient management in various endocrine disorders. (Endokrynol Pol 2019; 70 (4): 350-356)

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“…In a cross-sectional controlled study of premenopausal women with Graves' disease, Kuzma et al found that TBS [32].…”

Section: Discussionmentioning

confidence: 99%

Показатель Качества Трабекулярной Костной Ткани И Оценка Вертебральных Переломов У Португальских Пременопаузальных Женщин С Гипертиреозом

Barbosa

Mascarenhas

Bicho

et al. 2021

PJS

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Hyperthyroidism is a risk factor for reduced bone mineral density (BMD) and osteoporotic fractures. Vertebral fracture assessment (VFA) detects vertebral fractures and trabecular bone score (TBS) is an index of bone microarchitecture. We aimed to evaluate the effects of hyperthyroidism on BMD, soft body tissue composition, prevalence of silent vertebral fractures and TBS. Eighty Portuguese premenopausal women were divided and matched in overt hyperthyroidism (n = 40) and control (n = 40) groups. BMD (g/cm 2) at lumbar spine, hip, radius 33 % and whole body and the total body masses (kg) were studied by DXA. VFA was used to detect fractures and those were classified by Genant's semiquantitative method and confirmed by X-ray. TBS was obtained from lumbar spine DXA images. No patient had previously been treated for hyperthyroidism, osteoporosis or low bone mass. Adequate statistical tests were used. In the hyperthyroidism group, the mean BMD (total hip, femoral neck and whole body), the total lean mass and TBS were significantly lower; according to ISCD classification, there was a trend for a higher prevalence of low BMD; vertebral fractures were significantly higher. These results suggest that in a group of hyperthyroid premenopausal women there are significantly lower BMD, lean mass and TBS. The prevalence of silent vertebral fractures is also significantly higher.

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High Serum Fractalkine is Associated with Lower Trabecular Bone Score in Premenopausal Women with Graves’ Disease

Cited by 16 publications

References 25 publications

TSH suppressive therapy and bone

TSH suppressive therapy and bone

Trabecular bone score (TBS) as a noninvasive and complementary tool for clinical diagnosis of bone structure in endocrine disorders

Показатель Качества Трабекулярной Костной Ткани И Оценка Вертебральных Переломов У Португальских Пременопаузальных Женщин С Гипертиреозом

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