High Serum Essential Amino Acids as a Predictor of Skeletal Muscle Depletion in Patients With Cachexia and Advanced Gastrointestinal Cancers

Kitagawa, Moeko; Haji, Seiji; Amagai, Teruyoshi

doi:10.1177/0884533617724742

Cited by 11 publications

(9 citation statements)

References 21 publications

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“…Thirdly, high serum CRP suggests increased Interleukine 6 production [44], which promotes muscle protein breakdown by several mechanisms including both inhibition of muscle protein synthesis, repair, contractility and function [45], and stimulation of the hypothalamus-pitituary-cortical axis leading to increased cortisol production. Lastly, high EAA/TAA and BCAA/TAA ratios observed in the study patients were previously reported in cancer individuals with cachexia [46,47].…”

Section: Discussionsupporting

confidence: 77%

The relationship between plasma amino acids and circulating albumin and haemoglobin in postabsorptive stroke patients

et al. 2019

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Background This retrospective study had two main aims: (1) to document possible correlations between plasma Amino Acids (AAs) and circulating Albumin (Alb) and Haemoglobin (Hb); and (2) to identify which AAs were predictors of Alb and Hb. Methods The study considered 125 stroke subjects (ST) (61.6% males; 65.6 +/- 14.9 years) who met the eligibility criteria (absence of co morbidities associated with altered plasma AAs and presence of plasma AAs determined after overnight fasting). Fifteen matched healthy subjects with measured plasma AAs served as controls. Results The best correlations of Alb were with tryptophan (Trp) and histidine (His) (r = + 0.53; p < 0.0001), and those of Hb were with histidine (r = +0.47) and Essential AAs (r = +0.47) (both p<0.0001). In multivariate analysis, Trp (p< 0.0001) and His (p = 0.01) were shown to be the best positive predictors of Alb, whereas glutamine (p = 0.006) was the best positive predictor of Hb. Conclusions The study shows that the majority of plasma AAs were positively correlated with Alb and Hb. The best predictors of circulating Alb and Hb were the levels of tryptophan and glutamine, respectively.

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Section: Discussionsupporting

confidence: 77%

The relationship between plasma amino acids and circulating albumin and haemoglobin in postabsorptive stroke patients

et al. 2019

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“…Our data showing elevated levels of protein turnover, myofibrillar protein breakdown and muscle wasting correspond with other metabolic studies in small groups of cancer patients [19,48,58] and therefore we think that our study provides useful information about protein metabolism in patients undergoing chemotherapy. We showed that even in patients who would not be classified as pre-cachectic or cachectic, the body responds to the disease and the treatment, resulting in a significantly higher protein turnover and myofibrillar protein breakdown and many deteriorations in the production and clearance rate of amino acids, which were related to muscle function, physical function and quality of life.…”

Section: Weight Loss Sarcopenia and Obesitysupporting

confidence: 90%

Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function

et al. 2019

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“…The finding of an increased muscle hypercatabolism in our patients was supported by the fact that they were found to be affected by sarcopenia. Moreover, increased contributions of EAAs and BCAAs to TAAs are similar to those detected in cachectic cancer patients, 34,35 in whom increased EAA and BCAA/TAA ratios are associated with a decrease in psoas muscle volume. 36 On the other hand, acidosis and cancer share an increased ubiquitin-proteasome proteolytic pathway.…”

Section: Dialysis Techniques and Aa Lossessupporting

confidence: 52%

Differences in Amino Acid Loss Between High-Efficiency Hemodialysis and Postdilution and Predilution Hemodiafiltration Using High Convection Volume Exchange—A New Metabolic Scenario? A Pilot Study

Murtas

Aquilani

Deiana

et al. 2019

Journal of Renal Nutrition

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Objective: The objective of the study was to quantify the loss of total amino acids (TAAs), nonessential amino acids, essential amino acids, and branched chain amino acids (BCAAs) produced by high-efficiency hemodialysis (HEHD), postdilution hemodiafiltration (HDFpost), and predilution hemodiafiltration (HDFpre) using high ultrafiltration volumes; and to define the specific AA losses registered in HEHD, HDFpost, and HDFpre; to identify a potential metabolic and nutritional decline into protein energy wasting; to compare AA analysis of arterial blood samples taken from healthy controls and patients with end-stage renal disease undergoing hemodialysis. Design and Methods: Identical dialysis monitors, membranes, and dialysate/infusate were used to homogenize extracorporeal body influence. Ten patients were recruited and randomized to receive treatment with HEHD, HDFpost, and HDFpre it was used on-line dialytic water methodologies (OL); patients' AA arterial concentrations were measured at the start and on completion of dialysis; TAA from the dialyzer filter was calculated, and baseline levels were subsequently compared with findings obtained 1 year later. Finally, the results obtained were compared with the data from a study of 8 healthy volunteers conducted using bioimpedance analysis and laboratory blood tests to assess nutritional status. Results: A higher convective dose results in a higher weekly loss of TAA, nonessential AAs, essential AAs, and BCAAs (HEHD: 15.7 g; HDFpost-OL: 16.1 g; HDFpre-OL: 16.3 g, P , .01). After 12 months, the same hemodialys patients showed a reduced body and water intracellular mass and reduced phase angle. Arterial concentrations of TAAs and BCAAs were lower than those detected in healthy subjects (P , .01). Conclusion: The study shows that the AA losses in dialytic liquid are greater after high exchange volume HDF techniques, especially HDFpre. The AA losses are not metabolically compensated, so these increase the derangements of predialytic arterial plasma AA levels. Both AA losses and arterial AA perturbations further worsened body composition already after 12 months of additional dialysis.

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High Serum Essential Amino Acids as a Predictor of Skeletal Muscle Depletion in Patients With Cachexia and Advanced Gastrointestinal Cancers

Abstract: Higher serum EAA/TAA ratio and CRP were associated with depletion in psoas muscle area, which led to a diagnosis of sarcopenia, in patients with advanced gastrointestinal cancers. These parameters at baseline could be predictors of cancer cachexia.

Cited by 11 publications

References 21 publications

The relationship between plasma amino acids and circulating albumin and haemoglobin in postabsorptive stroke patients

The relationship between plasma amino acids and circulating albumin and haemoglobin in postabsorptive stroke patients

Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function

Differences in Amino Acid Loss Between High-Efficiency Hemodialysis and Postdilution and Predilution Hemodiafiltration Using High Convection Volume Exchange—A New Metabolic Scenario? A Pilot Study

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