High serum adiponectin is associated with favorable lipoprotein subclass profile in 6.4-year follow-up

Vanhala, Mauno; Kumpula, Linda S.; Soininen, Pasi; Kangas, Antti J.; Ala‐Korpela, Mika; Kautiainen, Hannu; Mäntyselkä, Pekka; Saltevo, Juha

doi:10.1530/eje-10-1065

Cited by 15 publications

(15 citation statements)

References 16 publications

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“…Common to both groups was the absence of an association between adiponectin and the most dense HDL subfraction. Previous publications have reported an association between adiponectin and HDL size (22) as well as with the number of large but not small HDL particles (23), including one study in which adiponectin levels were associated with a prospective rise in HDL size after 6.4 years of follow-up (24). Collectively, these findings suggest that adiponectin is linked to processes associated with increased HDL size and lipid content and with the number of large HDL particles.…”

Section: Discussionmentioning

confidence: 64%

Elevated Lipoprotein Lipase Activity Does Not Account for the Association Between Adiponectin and HDL in Type 1 Diabetes

Calderon¹,

Diaz²,

Szeto

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Discussionmentioning

confidence: 64%

Elevated Lipoprotein Lipase Activity Does Not Account for the Association Between Adiponectin and HDL in Type 1 Diabetes

Calderon¹,

Diaz²,

Szeto

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…1. The Pieksämäki cohort originally consisted of 1,294 subjects from the town of Pieksämäki in Eastern Finland (13,14). The eligible population consisted of all individuals born in 1942, 1947, 1952, 1957, and 1962, of which 71% (923) participated in the initial examination in 1997 and 690 of these attended a follow-up survey in 2003–2004.…”

Section: Methodsmentioning

confidence: 99%

Circulating Metabolite Predictors of Glycemia in Middle-Aged Men and Women

et al. 2012

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OBJECTIVEMetabolite predictors of deteriorating glucose tolerance may elucidate the pathogenesis of type 2 diabetes. We investigated associations of circulating metabolites from high-throughput profiling with fasting and postload glycemia cross-sectionally and prospectively on the population level.RESEARCH DESIGN AND METHODSOral glucose tolerance was assessed in two Finnish, population-based studies consisting of 1,873 individuals (mean age 52 years, 58% women) and reexamined after 6.5 years for 618 individuals in one of the cohorts. Metabolites were quantified by nuclear magnetic resonance spectroscopy from fasting serum samples. Associations were studied by linear regression models adjusted for established risk factors.RESULTSNineteen circulating metabolites, including amino acids, gluconeogenic substrates, and fatty acid measures, were cross-sectionally associated with fasting and/or postload glucose (P < 0.001). Among these metabolic intermediates, branched-chain amino acids, phenylalanine, and α1-acid glycoprotein were predictors of both fasting and 2-h glucose at 6.5-year follow-up (P < 0.05), whereas alanine, lactate, pyruvate, and tyrosine were uniquely associated with 6.5-year postload glucose (P = 0.003–0.04). None of the fatty acid measures were prospectively associated with glycemia. Changes in fatty acid concentrations were associated with changes in fasting and postload glycemia during follow-up; however, changes in branched-chain amino acids did not follow glucose dynamics, and gluconeogenic substrates only paralleled changes in fasting glucose.CONCLUSIONSAlterations in branched-chain and aromatic amino acid metabolism precede hyperglycemia in the general population. Further, alanine, lactate, and pyruvate were predictive of postchallenge glucose exclusively. These gluconeogenic precursors are potential markers of long-term impaired insulin sensitivity that may relate to attenuated glucose tolerance later in life.

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“…Low plasma adiponectin concentrations are associated with several obesity-related metabolic abnormalities, including increased fasting plasma glucose, total plasma triglyceride (TG), very low density lipoprotein (VLDL)-TG and VLDL-apolipoprotein B-100 (apoB-100) concentrations [7, 12-15]. These data suggest that adiponectin influences liver metabolism, because basal hepatic glucose and VLDL production are important determinants of plasma glucose and TG concentrations.…”

Section: Introductionmentioning

confidence: 99%

Portal vein and systemic adiponectin concentrations are closely linked with hepatic glucose and lipoprotein kinetics in extremely obese subjects

et al. 2011

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Objective Low systemic plasma adiponectin concentrations are associated with abnormalities in hepatic glucose and lipoprotein metabolism in obese people. However, the relationship between the delivery of adiponectin to the liver via the portal vein and hepatic glucose and lipoprotein metabolism is not known. Materials/Methods We examined the relationship between hepatic substrate metabolism (glucose rate of appearance (Ra) into plasma and hepatic very low density lipoprotein (VLDL)-triglyceride (TG) and apolipoprotein B-100 (apoB-100) secretion rates; determined by using stable isotope-labeled tracer techniques) and portal vein adiponectin concentration in 8 insulin-resistant, extremely obese subjects (body mass index: 65 ± 7 kg/m2). Results Portal vein adiponectin concentration was inversely associated with basal glucose Ra (r = −0.820, P = 0.013) and VLDL-TG (r = −0.823, P = 0.012) and VLDL-apoB-100 (r = −0.787, P = 0.020) secretion rates. Very similar correlations were obtained for radial artery adiponectin, as a result of a mirroring relationship between portal and arterial adiponectin concentrations (r = 0.899, P = 0.002) and the absence of significant arteriovenous concentration differences (P = 0.570). Insulin resistance, assessed with the homeostasis model assessment score, was also strongly associated with hepatic glucose and lipid metabolic parameters, as well as with adiponectin concentrations in the portal vein and radial artery. Conclusions These results suggest that adiponectin delivery to the liver, whether via the portal or the systemic circulation, may be an important regulator of basal hepatic glucose, VLDL-TG and VLDL-apoB-100 production rates in obese people, possibly through direct effects on the liver or changes in hepatic insulin sensitivity. However, portal vein adiponectin does not appear to be superior to arterial adiponectin as a marker of hepatic metabolic dysregulation. Additional studies are needed to elucidate the mechanism(s) responsible for the strong association we observed between adiponectin and hepatic substrate metabolism.

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High serum adiponectin is associated with favorable lipoprotein subclass profile in 6.4-year follow-up

Cited by 15 publications

References 16 publications

Elevated Lipoprotein Lipase Activity Does Not Account for the Association Between Adiponectin and HDL in Type 1 Diabetes

Elevated Lipoprotein Lipase Activity Does Not Account for the Association Between Adiponectin and HDL in Type 1 Diabetes

Circulating Metabolite Predictors of Glycemia in Middle-Aged Men and Women

Portal vein and systemic adiponectin concentrations are closely linked with hepatic glucose and lipoprotein kinetics in extremely obese subjects

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