High serotonin levels due to the presence of the acanthocephalan Hexaglandula corynosoma could promote changes in behavior of the fiddler crab Uca spinicarpa

Pérez-Campos, Ruth A.; Rodríguez-Canul, Rossanna; Pérez-Vega, Juan Antonio; González‐Salas, Carlos; Guillén-Hernández, Sergio

doi:10.3354/dao02453

Cited by 7 publications

(8 citation statements)

References 22 publications

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“…Serotonin and serotonin analogs have been shown to alter agonistic behaviors (McPhee & Wilkens, 1989; Tierney & Mangiamele, 2001) and activity levels (Fong & Ford, 2014; Perez‐Campos, Rodriguez‐Canul, Perez‐Vega, Gonzalez‐Salas, & Guillen‐Hernandez, 2012) in crustaceans. Fluoxetine concentrations ≥120 μg/L caused a stimulation of locomotor behavior in the crab Carcinus maenas (Mesquita et al., 2011).…”

Section: Discussionmentioning

confidence: 99%

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Peters

Granek

Rivera

et al. 2017

Ecology and Evolution

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Predators exert considerable top‐down pressure on ecosystems by directly consuming prey or indirectly influencing their foraging behaviors and habitat use. Prey is, therefore, forced to balance predation risk with resource reward. A growing list of anthropogenic stressors such as rising temperatures and ocean acidification has been shown to influence prey risk behaviors and subsequently alter important ecosystem processes. Yet, limited attention has been paid to the effects of chronic pharmaceutical exposure on risk behavior or as an ecological stressor, despite widespread detection and persistence of these contaminants in aquatic environments. In the laboratory, we simulated estuarine conditions of the shore crab, Hemigrapsus oregonensis, and investigated whether chronic exposure (60 days) to field‐detected concentrations (0, 3, and 30 ng/L) of the antidepressant fluoxetine affected diurnal and nocturnal risk behaviors in the presence of a predator, Cancer productus. We found that exposure to fluoxetine influenced both diurnal and nocturnal prey risk behaviors by increasing foraging and locomotor activity in the presence of predators, particularly during the day when these crabs normally stay hidden. Crabs exposed to fluoxetine were also more aggressive, with a higher frequency of agonistic interactions and increased mortality due to conflicts with conspecifics. These results suggest that exposure to field‐detected concentrations of fluoxetine may alter the trade‐off between resource acquisition and predation risk among crabs in estuaries. This fills an important data gap, highlighting how intra‐ and interspecific behaviors are altered by exposure to field concentrations of pharmaceuticals; such data more explicitly identify potential ecological impacts of emerging contaminants on aquatic ecosystems and can aid water quality management.

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Section: Discussionmentioning

confidence: 99%

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Peters

Granek

Rivera

et al. 2017

Ecology and Evolution

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“…Absorbance readings for both neuromodulators were taken at 25° C at 450 nm (650 nm reference wavelength). Quantification of known samples (as μg ml −1 ) was achieved by comparing their absorbance with a reference curve prepared with known standard concentrations [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

“…argus remained to be determined. In crustacean hosts, parasites may affect the nutritional condition, blood chemistry, or concentration of hemocytes in the hemolymph [ 28 ], the escape response [ 29 – 31 ], or the concentration of certain biogenic amines (neurotransmitters, neuromodulators, and neurohormones), causing behavioral changes that may increase their vulnerability to predators [ 6 , 32 ]. Therefore, in species of commercial value, such as spiny lobsters, parasites may indirectly affect the fisheries if infected lobsters are more susceptible to predation [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…solearis altered the concentration of two biogenic amines in the host’s plasma: dopamine (DA), which is involved in gonad maturation, carbohydrate metabolism, and learning processes, and serotonin (5-HT), which modulates response to stress, sexual and agonistic behavior, physiological process (including control of energy balance), circadian rhythms, and neurogenesis [ 35 – 38 ]. We did this because changes in the concentration of biogenic amines may alter the host’s activity patterns or choice of microhabitat, potentially increasing exposure to predators [ 6 , 8 , 32 , 39 ]. In crustaceans, the concentration of hemocytes in the hemolymph may increase as part of the immune response [ 40 ] or decrease as a result of heavy infections [ 41 , 42 ], although the hemocyte counts may increase or decrease in the same host depending on the type of parasite [ 43 – 45 ]; therefore, we examined this trait in the P .…”

Section: Introductionmentioning

confidence: 99%

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Effects of Cymatocarpus solearis (Trematoda: Brachycoeliidae) on its second intermediate host, the Caribbean spiny lobster Panulirus argus

Franco-Bodek,

Barradas-Ortiz,

Negrete-Soto

et al. 2023

PLoS ONE

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Many digenean trematodes require three hosts to complete their life cycle. For Cymatocarpus solearis (Brachycoeliidae), the first intermediate host is unknown; the Caribbean spiny lobster Panulirus argus is a second intermediate host, and the loggerhead turtle Caretta caretta, a lobster predator, is the definitive host. Trophically-transmitted parasites may alter the behavior or general condition of intermediate hosts in ways that increase the hosts’ rates of consumption by definitive hosts. Here, we examined the effects of infection by C. solearis on P. argus by comparing several physiological and behavioral variables among uninfected lobsters (0 cysts) and lobsters with light (1–10 cysts), moderate (11–30 cysts), and heavy (>30 cysts) infections. Physiological variables were hepatosomatic index, growth rate, hemocyte count, concentration in hemolymph of cholesterol, protein, albumin, glucose, dopamine (DA) and serotonin (5-HT). Behavioral variables included seven components of the escape response (delay to escape, duration of swimming bout, distance traveled in a swimming bout, swim velocity, acceleration, force exerted, and work performed while swimming). There was no relationship between lobster size or sex and number of cysts. Significant differences among the four lobster groups occurred only in concentration of glucose (lower in heavily infected lobsters) and 5-HT (higher in heavily and moderately infected lobsters) in plasma. As changes in 5-HT concentration can modify the host’s activity patterns or choice of microhabitat, our results suggest that infection with C. solearis may alter the behavior of spiny lobsters, potentially increasing the likelihood of trophic transmission of the parasite to the definitive host.

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“…It is also clear that 5-HT has a role to play in this helminth–host interaction and a few examples of this are provided. For instance, acantocephalans (thorny-headed worms) affected behavior of their arthropod host that was associated with increased or decreased 5-HT-immunoreactivity in the hosts’ brain [ 121 , 122 ]. Indeed, neuro-inflammation has been postulated as an important consequence downstream of serotonergic dysfunction in infected gammarids [ 123 ].…”

Section: Serotonin Behavior and Immunitymentioning

confidence: 99%

Modulation of the immune response by helminths: a role for serotonin?

Wang¹,

Sharkey

McKay³

2018

Bioscience Reports

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The mammalian gut is a remarkable organ: with a nervous system that rivals the spinal cord, it is the body’s largest repository of immune and endocrine cells and houses an immense and complex microbiota. Infection with helminth parasites elicits a conserved program of effector and regulatory immune responses to eradicate the worm, limit tissue damage, and return the gut to homeostasis. Discrete changes in the nervous system, and to a lesser extent the enteroendocrine system, occur following helminth infection but the importance of these adaptations in expelling the worm is poorly understood. Approximately 90% of the body’s serotonin (5-hydroxytryptamine (5-HT)) is made in enterochromaffin (EC) cells in the gut, indicative of the importance of this amine in intestinal function. Signaling via a plethora of receptor subtypes, substantial evidence illustrates that 5-HT affects immunity. A small number of studies document changes in 5-HT levels following infection with helminth parasites, but these have not been complemented by an understanding of the role of 5-HT in the host–parasite interaction. In reviewing this area, the gap in knowledge of how changes in the enteric serotonergic system affects the outcome of infection with intestinal helminths is apparent. We present this as a call-to-action by investigators in the field. We contend that neuronal EC cell–immune interactions in the gut are essential in maintaining homeostasis and, when perturbed, contribute to pathophysiology. The full affect of infection with helminth parasites needs to define, and then mechanistically dissect the role of the enteric nervous and enteroendocrine systems of the gut.

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High serotonin levels due to the presence of the acanthocephalan Hexaglandula corynosoma could promote changes in behavior of the fiddler crab Uca spinicarpa

Cited by 7 publications

References 22 publications

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Effects of Cymatocarpus solearis (Trematoda: Brachycoeliidae) on its second intermediate host, the Caribbean spiny lobster Panulirus argus

Modulation of the immune response by helminths: a role for serotonin?

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