High seroprevalence of dengue virus indicates that dengue virus infections are frequent in central and eastern Sudan

Adam, Awadalkareem; Schüttoff, Tom; Reiche, Sven; Jassoy, Christian

doi:10.1111/tmi.13116

Cited by 15 publications

(14 citation statements)

References 23 publications

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“…This includes analyzing the studies sub-grouped by study type, location, and the test performed to detect DENV infection. Temporal variation was investigated by sub-grouping studies by the diagnostic test performed, IgG to assess the previous exposure to the virus, and IgM to assess the recent acute infection [ 33 ]. The prevalence of the DENV-IgG 38% (95% C.I.…”

Section: Discussionmentioning

confidence: 99%

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High Seroprevalence of Dengue Virus Infection in Sudan: Systematic Review and Meta-Analysis

et al. 2020

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The goal of this study was to systematically review the published data on dengue virus (DENV) seroprevalence in Sudan and to estimate disease burden through meta-analysis. We searched, reviewed, and extracted online available reports on DENV in Sudan. Among 168 identified records, 19 were selected. Dengue infections were documented in 11/18 states. The overall seroprevalence of DENV in Sudan was estimated to be 27%, while the prevalence of dengue IgM was 22% and IgG was 38%. The prevalence of dengue estimated from community and hospital-based cross-sectional studies were 26% and 30% respectively. Additionally, one cohort study and a single PCR-based study reported a prevalence of 1% and 4%, respectively. Regional analysis revealed that the variation in seroprevalence in East, North, West, and Central Sudan was 23%, 24%, 36% and 43%, respectively. Interestingly, we found that DENV is circulating countrywide with a significant spatiotemporal variation in the disease seroprevalence. Furthermore, publications on dengue prevalence are temporally and geographically fragmented, perhaps due to limited resources. However, this gap in data and knowledge highlights the urgent need for a country-wide surveillance system and continued study of dengue burden in Sudan to accurately estimate the disease prevalence and determine the associated risk factors.

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Section: Discussionmentioning

confidence: 99%

“…26–51%) was significantly higher than DENV-IgM 22% (95% C.I. 13–31%) indicating that the DENV transmission was likely both endemic as well as epidemic [ 33 ]. The estimated seroprevalence of DENV was similar between community-based and hospital-based studies with 26% (95% C.I.…”

Section: Discussionmentioning

confidence: 99%

High Seroprevalence of Dengue Virus Infection in Sudan: Systematic Review and Meta-Analysis

et al. 2020

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“…Additionally, studies reported a high prevalence (67%) of DENV infections in Sudan and up to 89% in the coastal area. They highlighted that most people in these areas were infected repeatedly, and reported that all DENV (1-4) serotypes are circulating in the area [52,53]. Recently, DENV-1 and 3 emerged and caused an outbreak of dengue fever in the Darfur area, western Sudan [54].…”

Section: Dengue Virusmentioning

confidence: 99%

Risks and Challenges of Arboviral Diseases in Sudan: The Urgent Need for Actions

Ahmed

Dietrich

LaBeaud

et al. 2020

Viruses

105

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The risk of emergence and/or re-emergence of arthropod-borne viral (arboviral) infections is rapidly growing worldwide, particularly in Africa. The burden of arboviral infections and diseases is not well scrutinized because of the inefficient surveillance systems in endemic countries. Furthermore, the health systems are fully occupied by the burden of other co-existing febrile illnesses, especially malaria. In this review we summarize the epidemiology and risk factors associated with the major human arboviral diseases and highlight the gap in knowledge, research, and control in Sudan. Published data in English up to March 2019 were reviewed and are discussed to identify the risks and challenges for the control of arboviruses in the country. In addition, the lack of suitable diagnostic tools such as viral genome sequencing, and the urgent need for establishing a genomic database of the circulating viruses and potential sources of entry are discussed. Moreover, the research and healthcare gaps and global health threats are analyzed, and suggestions for developing strategic health policy for the prevention and control of arboviruses with focus on building the local diagnostic and research capacity and establishing an early warning surveillance system for the early detection and containment of arboviral epidemics are offered.

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“…The severity of DENV infection varies from mild fever to complicated clinical hemorrhagic disease leading to shock and subsequent death [6][7][8]. In the recent years, DENV has spread significantly to different States of Sudan [9][10][11][12]. Currently, DENV infection constitutes one of the major unresolved public health problems in the country.…”

Section: Backgroudmentioning

confidence: 99%

Association of genotype III of dengue virus serotype 3 with disease outbreak in Eastern Sudan, 2019

Eldigail

Abubaker

Khalid

et al. 2020

Virol J

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Background: Dengue fever (DF) is an arthropod-borne disease caused by dengue virus (DENV). DENV is a member of the genus Flavivirus in the family Flaviviridae. Recently, DENV has been reported as an important emerging infectious viral pathogen in Sudan. Multiple outbreaks and sporadic cases of DF have been frequently reported in the eastern region of Sudan. The present study was conducted to confirm DENV outbreak in Kassala State, eastern Sudan, 2019, and to provide some information on the molecular characterization of the DENV isolate associated with the disease outbreak. Methods: A hundred serum samples were collected during the outbreak from residents of Kassala State, Sudan, 2019. ELISA was used to detect DENV non structural protein NS1 (DENV-NS1) in acute phase sera sampled during the disease outbreak. RT-PCR assays were used to amplify a fragment of the capsid/pre-membrane region (CprM) of the viral polyprotein gene. The PCR products of the amplified CprM region of the viral polyprotein gene were purified and partial sequences were generated and used to confirm the specificity of DENV sequences and to identify the virus serotype. Phylogenetic tree was constructed to determine the genotype of DENV associated with the outbreak. Results: Using DENV-NS1 ELISA assay, DENV infection was confirmed in 23% sampled sera. The detection of DENV RNA was made possible using group-specific RT-PCR assay. The virus was serotyped as DENV serotype 3 (DENV-3) using DENV serotype-specific RT-PCR assay. Phylogenetic analysis of the partial CprM sequences of the viral polyprotein gene indicates that the virus belonged to genotype III of DENV-3. Conclusion: The scientific data presented in this investigation confirmed that genotype III of DENV-3 was associated with the disease outbreak in eastern Sudan, 2019. The study represents the first report on molecular characterization of DENV-3 in Sudan.

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High seroprevalence of dengue virus indicates that dengue virus infections are frequent in central and eastern Sudan

Cited by 15 publications

References 23 publications

High Seroprevalence of Dengue Virus Infection in Sudan: Systematic Review and Meta-Analysis

High Seroprevalence of Dengue Virus Infection in Sudan: Systematic Review and Meta-Analysis

Risks and Challenges of Arboviral Diseases in Sudan: The Urgent Need for Actions

Association of genotype III of dengue virus serotype 3 with disease outbreak in Eastern Sudan, 2019

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