High Seroprevalence of Anti-SARS-CoV-2 IgM/IgG among Inhabitants of Sakaka City, Aljouf, Saudi Arabia

Taha, Ahmed E.; Alduraywish, Abdulrahman; Almaeen, Abdulrahman H.; Alayyaf, Mohammad; Mallick, Ayesha; Abouelkheir, Mohamed

doi:10.3390/vaccines11010026

Cited by 3 publications

(3 citation statements)

References 57 publications

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“…Several studies have identified multiple factors associated with seropositivity, such as sex ( 20 , 21 ), age ( 20 , 21 ), obesity ( 20 ), exposure to more than one case among nonhousehold contacts ( 22 ), presence of multiple comorbidities ( 20 ), and previous performance of a PCR test ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of COVID-19 in Oran: Cross-Sectional Study

Dali-Ali

Derkaoui

Zina³

et al. 2023

Microbiol Spectr

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of COVID-19 in Oran: Cross-Sectional Study

Dali-Ali

Derkaoui

Zina³

et al. 2023

Microbiol Spectr

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“…However, the world is trying to counteract the bad effect of the coronavirus disease 2019 (COVID-19) pandemic, caused by SARS-CoV-2 (50, 51), on the communities, health systems, and economies (52,53). Anti-SARS-CoV-2 vaccination constitutes the most promising prevention and control measure (54,55). Recently, a few cases of herpes keratitis (approved by polymerase chain reaction [PCR]) due to the reactivation of HSV after receiving anti-SARS-CoV-2 mRNA vaccination were detected in Saudi Arabia (56), the United Kingdom (57), and Jordan (58).…”

Section: Discussionmentioning

confidence: 99%

Estimation of Seroprevalence of Anti-Herpes Simplex Virus Type-1 IgG Among Healthy Blood Donors in Sakaka City, Aljouf, Saudi Arabia

Taha

Ghazy

Almaeen

et al. 2023

Jundishapur J Microbiol

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Background: Herpes simplex virus type-1 (HSV-1) is a highly infectious neurotropic virus. The data on HSV-1 infection in Saudi Arabia, including the seroprevalence of HSV-1 antibodies, are scarce. Objectives: This is the first study to evaluate the prevalence of anti-HSV-1 immunoglobulin G (IgG) in donated blood in Sakaka, Aljouf, Saudi Arabia. Methods: A total of 300 donated blood samples were collected from the Blood Bank of Prince Mutaib Bin Abdulaziz Hospital in Sakaka. Sensitive and specific enzyme-linked immunosorbent assay (ELISA) was used to detect anti-HSV-1 IgG. A comparison of the age, gender, education, occupation, income, hand hygiene, travel history, and cupping practice of blood donors stratified for the extent of anti-HSV-1 IgG was made. Results: There was a low prevalence of anti-HSV-1 IgG (20%; n = 60/300). Moreover, 50.0% of IgG-positive participants were in the age group of 41 - 45 years, and 81.7% of the participants had a household income of < 10000 SAR (statistically highly significant; P < 0.001*). All the participants performed hand washing with soap before handling food and after using the toilet. Furthermore, IgG-positive participants had a bachelor’s degree (50.0%), were governmental employees (60.0%), were international travelers (50.0%), and practiced cupping (50.0%) with statistically significant associations (P < 0.05*). Conclusions: The current study’s findings support previous reports about the key importance of improving socioeconomic conditions and hygiene measures in reducing the spread of HSV-1. The present study provides an alarm regarding reaching the age of sexual debut without acquiring protective anti-HSV-1 immunoglobulins, consequently becoming more susceptible to acquiring HSV-1 infection through the genital route. These data support the urgent need to develop an effective anti-HSV-1 vaccine.

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“….А., Тотолян А.А. Характеристика набора реагентов «N-CoV-2-IgG PS» для количественного определения IgG человека к нуклеокапсидному белку SARS-CoV-2 // Инфекция и иммунитет 2022…”

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Assessment of the level of immune layer to SARS-CoV-2 in children under conditions of novel coronavirus infection COVID-19

Евсеева

Lazareva

Vlasova

et al. 2023

Bûlletenʹ fiziologii i patologii dyhaniâ

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Introduction. Asymptomatic transmission of the coronavirus poses a significant threat to efforts to reduce the incidence of COVID-19. A specific humoral immune response against SARS-CoV-2 can be induced in most symptomatic cases and in asymptomatic carriers. Determining the pattern of antibody response to SARS-CoV-2 infection in children can provide important information for improving screening and targeted protection of population that continue to suffer from this pandemic. Aim. To determine the level of antibodies to SARS-CoV-2 in children during the COVID19 epidemic. Materials and methods. Serum samples from 254 clinic patients from 1 to 17 years old, with an average age of 9.7±0.3 years, were studied by random selection. The analysis was carried out in 2 groups of patients: patients who underwent COVID-19 in the period from January 2021 to March 2022 with a positive SARS-CoV-2 PCR result (n=36) and a control group of children who deny the disease (n=218). IgM and IgG were determined in blood serum samples by means of ELISA using the SARS CoV-2-IgM and SARS CoV-2-IgG quantitative diagnostic kits (Vector-Best, Novosibirsk, Russia). Results. In the group of children who did not have COVID-19, negative results were detected in 25.2% of cases. IgG antibodies specific to SARS-CoV-2 were detected in 74.8% of patients, of which a low level of virus-neutralizing activity was found in 15.6% of patients, an average level in 20.2% of cases, and a high level in 39.0% of cases. In the group of children who had the disease, a low level of virus-neutralizing activity was detected in 29.4%, an average level in 32.4%, and a high level of IgG antibodies to SARS-CoV-2 was detected in 38.2% of cases. In the group of children who underwent COVID-19, 77.8% of the disease proceeded with symptoms of acute respiratory viral infections, 22.2% had CT signs of pneumonia, and there were no significant differences in the levels of specific antibodies. In the group of children who underwent COVID-19, 77.8% of the disease proceeded with symptoms of acute respiratory viral infections, 22.2% had CT signs of pneumonia, and there were no significant differences in the levels of specific antibodies. Analysis of seroprevalence in dynamics after the disease showed that the highest level of antibodies persisted for 2-4 months. after an illness. Conclusion. The proportion of asymptomatic forms of infection among children and adolescents is quite high. These undocumented infections often go unrecognized due to mild or absence of symptoms and, depending on their contagiousness and number of contacts, may play a significant role in the transmission of SARS-CoV-2. The findings raise important questions that should be explored in further studies regarding the role of serological tests in assessing the true extent of SARS-CoV-2 exposure in pediatric populations, as well as monitoring the response and duration of SARS-CoV2 antibody-mediated immunity.

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High Seroprevalence of Anti-SARS-CoV-2 IgM/IgG among Inhabitants of Sakaka City, Aljouf, Saudi Arabia

Cited by 3 publications

References 57 publications

Seroprevalence of COVID-19 in Oran: Cross-Sectional Study

Seroprevalence of COVID-19 in Oran: Cross-Sectional Study

Estimation of Seroprevalence of Anti-Herpes Simplex Virus Type-1 IgG Among Healthy Blood Donors in Sakaka City, Aljouf, Saudi Arabia

Assessment of the level of immune layer to SARS-CoV-2 in children under conditions of novel coronavirus infection COVID-19

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