High Sensitivity Surface Plasmon Resonance Sensor Based on Periodic Multilayer Thin Films

Cai, Hong; Shan, Shihan; Wang, Xiaoping

doi:10.3390/nano11123399

Cited by 17 publications

(4 citation statements)

References 45 publications

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“…The high sensitivity is because the presence of the MoS 2 layer increases the efficiency of light absorption of the sensor. Most of the incident light energy is transferred to free electrons on the sensor surface, so more surface plasmons are generated, which results in the higher sensitivity [33,34]. In Figure 2c, the monolayer graphene is covered on top of the MoS 2 layer to further improve the sensitivity.…”

Section: Numerical Simulation Design the Proposed Spr Biosensormentioning

confidence: 99%

Performance Enhancement of SPR Biosensor Using Graphene–MoS2 Hybrid Structure

Cai

Wang

et al. 2022

Nanomaterials

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We investigate a high-sensitivity surface plasmon resonance (SPR) biosensor consisting of a Au layer, four-layer MoS2, and monolayer graphene. The numerical simulations, by the transfer matrix method (TMM), demonstrate the sensor has a maximum sensitivity of 282°/RIU, which is approximately 2 times greater than the conventional Au-based SPR sensor. The finite difference time domain (FDTD) indicates that the presence of MoS2 film generates a strong surface electric field and enhances the sensitivity of the proposed SPR sensor. In addition, the influence of the number of MoS2 layers on the sensitivity of the proposed sensor is investigated by simulations and experiments. In the experiment, MoS2 and graphene films are transferred on the Au-based substrate by the PMMA-based wet transfer method, and the fabricated samples are characterized by Raman spectroscopy. Furthermore, the fabricated sensors with the Kretschmann configuration are used to detect okadaic acid (OA). The okadaic acid–bovine serum albumin bioconjugate (OA-BSA) is immobilized on the graphene layer of the sensors to develop a competitive inhibition immunoassay. The results show that the sensor has a very low limit of detection (LOD) of 1.18 ng/mL for OA, which is about 22.6 times lower than that of a conventional Au biosensor. We believe that such a high-sensitivity SPR biosensor has potential applications for clinical diagnosis and immunoassays.

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Section: Numerical Simulation Design the Proposed Spr Biosensormentioning

confidence: 99%

Performance Enhancement of SPR Biosensor Using Graphene–MoS2 Hybrid Structure

Cai

Wang

et al. 2022

Nanomaterials

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“…To enhance LMR sensor performance, researchers have explored various 2D materials with appropriate refractive indices for the lossy layer [16][17][18]. In 2018, graphene was introduced as a lossy material and achieved a figure of merit (FOM) of 410 refractive index unit −1 (RIU −1 ) [19].…”

Section: Introductionmentioning

confidence: 99%

Lossy Mode Resonance Sensors Based on Anisotropic Few-Layer Black Phosphorus

Shen,

Zhu,

Chen

et al. 2024

Nanomaterials

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Lossy mode resonance (LMR) sensors offer a promising avenue to surpass the constraints of conventional surface plasmon resonance (SPR) sensors by delivering enhanced label-free detection capabilities. A notable edge of LMR over SPR is its excitation potential by both transverse electric (TE) and transverse magnetic (TM) polarized light. Yet this merit remains underexplored due to challenges to achieving high sensing performance under both TM and TE polarization within a singular LMR model. This study introduces a theoretical model for an LMR prism refractive index sensor based on a MgF2-few layer black phosphorus-MgF2 configuration, which can achieve angular sensitivity nearing 90∘ refractive index unit−1 (RIU−1) for both polarizations. Leveraging the distinct anisotropic nature of black phosphorus, the figure of merit (FOM) values along its two principal crystal axes (zigzag and armchair) show great difference, achieving an impressive FOM of 1.178 × 106 RIU−1 along the zigzag direction under TE polarized light and 1.231 × 104 RIU−1 along the armchair direction under TM polarized light. We also provide an analysis of the electric field distribution for each configuration at its respective resonant conditions. The proposed structure paves the way for innovative applications of anisotropic-material-based LMR sensors in various applications.

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“…The choice of the SPR active metal, such as Au, Ag, or Al, has a significant impact on the sensitivity of the SPR-based sensor. Gold (Au) shows excellent optical properties in these materials, such as high resistance against oxidation and corrosion and high chemical stability, but leads to a large broadening of the SPR curve, which reduces the sensor's accuracy for sensing medium detection [15]. On the other side, Silver (Ag) and Aluminum (Al) provide a sharp SPR curve, but they have chemical instability [16].…”

Section: Introductionmentioning

confidence: 99%

“…The conventional sensors in the Kretschmann configuration consist of a single thin metallic film over the coupling prism. However, these sensors show a low sensitivity in the range 50-150°/ RIU due to the absorption loss of the metal [15]. In order to enhance the sensitivity of the conventional sensor, the single metallic layer can be replaced by a bimetallic layer.…”

Section: Introductionmentioning

confidence: 99%

SPR-Based refractive index sensor using BaTiO₃ and WS₂ with Al-Ni bimetal for glucose sensing

Uwais,

Bijalwan,

Rastogi

2023

Phys. Scr.

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In this work, we propose a high-performance surface plasmon resonance (SPR)-based refractive index biosensor to determine the glucose concentration in the urine samples. To achieve the most efficient design for the sensor, four possible designs have been investigated. The proposed design of the sensor uses the Kretschmann configuration, which consists of a BK7 glass prism with Aluminum (Al) and Nickel (Ni) metallic layers separated by a dielectric layer of barium titanate ( BaTiO 3 ), and a 2D material tungsten disulfide ( WS 2 ) layer placed above the Ni layer. The dielectric layer of BaTiO 3 is used to enhance the shift in the resonance angle and WS 2 to increase the absorption of the biomolecules, which results in an increase in the sensitivity of the sensor. The performance of the sensor has been numerically investigated using the transfer matrix method at 633 nm wavelength. Minimum reflectance at resonance is studied to show the coupling strength of the incident light with the surface plasmons. The thicknesses of the Al and Ni metallic layers have been optimized for maximum sensitivity and minimum reflectance at the resonance. The performance of the proposed sensor has been investigated to obtain sensitivity for different glucose concentrations in the urine samples. The sensor has a sensitivity of 330.5 ° / RIU for glucose concentration in the range 0 − 10 g\dl . The corresponding glucose concentration sensitivity is 0.4 ° / ( g / dl ) . The proposed study would be helpful in designing the refractive index-based biosensor for medical diagnostics applications.

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High Sensitivity Surface Plasmon Resonance Sensor Based on Periodic Multilayer Thin Films

Cited by 17 publications

References 45 publications

Performance Enhancement of SPR Biosensor Using Graphene–MoS2 Hybrid Structure

Performance Enhancement of SPR Biosensor Using Graphene–MoS2 Hybrid Structure

Lossy Mode Resonance Sensors Based on Anisotropic Few-Layer Black Phosphorus

SPR-Based refractive index sensor using BaTiO₃ and WS₂ with Al-Ni bimetal for glucose sensing

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High Sensitivity Surface Plasmon Resonance Sensor Based on Periodic Multilayer Thin Films

Cited by 17 publications

References 45 publications

Performance Enhancement of SPR Biosensor Using Graphene–MoS2 Hybrid Structure

Performance Enhancement of SPR Biosensor Using Graphene–MoS2 Hybrid Structure

Lossy Mode Resonance Sensors Based on Anisotropic Few-Layer Black Phosphorus

SPR-Based refractive index sensor using BaTiO3 and WS2 with Al-Ni bimetal for glucose sensing

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Product

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SPR-Based refractive index sensor using BaTiO₃ and WS₂ with Al-Ni bimetal for glucose sensing