High sensitivity of diffusion tensor imaging in discriminating idiopathic demyelinating optic neuritis

Zhang, Yan; Sihai, Wan; Wu, Guijun; Zhang, Xuelin

doi:10.18240/ijo.2016.07.25

Cited by 1 publication

(3 citation statements)

References 21 publications

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“…RD seems to have enhanced discriminatory value compared to FA for detecting the effects of ON within the visual system ( Figure 3B ). Within the optic nerve, a significant increase of RD was found for eleven out of sixteen performed comparisons, with five resulting from acute ON ( 27 , 28 , 103 , 104 ) and six from remote ON ( 25 , 26 , 103 , 109 ), though the ratio of significance was higher for acute ON. When assessing their ON patient group with a wide range of time from onset (median of 4.0 years since the first instance of ON), Naismith and colleagues [2010] ( 26 ) reported that they were able to distinguish the affected optic nerve from the unaffected optic nerve based on RD, while also differentiating between severity of visual outcomes (mild to severe).…”

Section: Resultsmentioning

confidence: 92%

“…When comparing ON subjects with healthy controls, decreased FA has been found in the optic nerve ( 103 , 104 ), and optic radiation ( 103 , 105 - 107 ) (including up to the visual cortex ( 105 , 108 ) (see Table S6 ). This decrease in FA between ON subjects and healthy controls was observable for both acute ( 103 - 105 ) and remote ( 103 , 106 , 107 ) forms of ON, showing that ON is associated with long term FA alterations along the primary visual system pathway.…”

Section: Resultsmentioning

confidence: 99%

“…MD increases have been found in the optic nerve ( 25 , 28 , 102 - 104 , 108 , 109 ) and optic radiations ( 105 ), as well as within the occipital lobe ( 112 ). These findings, however, are slightly sparser than for FA and RD, especially in the optic radiations ( Figure 3B ).…”

Section: Resultsmentioning

confidence: 99%

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Diffusion tensor imaging of optic neuropathies: a narrative review

Cooper,

Tchernykh,

Shmuel

et al. 2024

Quant Imaging Med Surg

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Background and Objective Diffusion tensor imaging (DTI) has been implemented in a breadth of scientific investigations of optic neuropathies, though it has yet to be fully adopted for diagnosis or prognosis. This is potentially due to a lack of standardization and weak replication of results. The aim of this investigation was to review DTI results from studies specific to three distinct optic neuropathies in order to probe its current clinical utility. Methods We reviewed the DTI literature specific to primary open-angle glaucoma (POAG), optic neuritis (ON), and traumatic optic neuropathy (TON) by systematically searching the PubMed database on March 1 st , 2023. Four distinct DTI metrics are considered: fractional anisotropy (FA), along with mean diffusivity (MD, axial diffusivity (AD), and radial diffusivity (RD). Results from within-group, between-group, and correlational studies were thoroughly assessed. Key Content and Findings POAG studies most consistently report a decrease in FA, especially in the optic radiations, followed in prevalence by an increase in RD and then MD, whilst AD yields conflicting results between studies. It is notable that there is not an equal distribution of investigated DTI metrics, with FA utilized the most, followed by MD, RD, and AD. Studies of ON are similar in that the most consistent findings are specific to FA, RD, and MD. These results are specific to the optic nerve and radiation since only one study measured the intermediary regions. More studies are needed to assess the effect that ON has on the tracts of the visual system. Finally, only three studies assessing DTI of TON have been performed to date, displaying low to moderate replicability of results. To improve the level of agreement between studies assessing each optic neuropathy, an increased level of standardization is recommended. Conclusions Both POAG and ON studies have yielded some prevalent DTI findings, both for contrast and correlation-based assessments. Although the clinical need is high for TON, considering the limitations of the current diagnostic tools, too few studies exist to make confident conclusions. Future use of standardized and longitudinal DTI, along with the foreseen methodological and technical improvements, is warranted to effectively study optic neuropathies.

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