High‐sensitivity CRP: Possible link between job stress and atherosclerosis

Xu, Weiting; Chen, Baoxia; Guo, Lijun; Li, Zhaoping; Zhao, Yiming; Zeng, Hui

doi:10.1002/ajim.22470

Cited by 18 publications

(12 citation statements)

References 37 publications

(50 reference statements)

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“…These variables are used as markers of potential psychobiological pathways mediating stressful experience with disease development. They include studies with experimental or cross-sectional design, where cardiovascular (six reports) [ 32 , 33 , 34 , 35 , 36 , 37 ], immune (three reports) [ 38 , 39 , 40 ] and hormonal parameters (seven reports) [ 32 , 41 , 42 , 43 , 44 , 45 , 46 ] were analyzed. As one report analyzed two different psychobiological markers [ 32 ] the number of studies presented in Table 1 is 27 instead of 28.…”

Section: Resultsmentioning

confidence: 99%

“…Immune system-related variables analyzed in this context include natural killer (NK) cells, T helper cells, and C-reactive protein (CRP) as an inflammatory marker. Two reports found significant associations of OC with increased CRP [ 38 ] and with reduced NK cells respectively. In this latter study, a lower increase of T helper cells following stress was also observed in association with OC and to some extent with ERI [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

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Associations of Extrinsic and Intrinsic Components of Work Stress with Health: A Systematic Review of Evidence on the Effort-Reward Imbalance Model

Siegrist

2016

IJERPH

185

216

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Mainstream psychological stress theory claims that it is important to include information on people’s ways of coping with work stress when assessing the impact of stressful psychosocial work environments on health. Yet, some widely used respective theoretical models focus exclusively on extrinsic factors. The model of effort-reward imbalance (ERI) differs from them as it explicitly combines information on extrinsic and intrinsic factors in studying workers’ health. As a growing number of studies used the ERI model in recent past, we conducted a systematic review of available evidence, with a special focus on the distinct contribution of its intrinsic component, the coping pattern “over-commitment”, towards explaining health. Moreover, we explore whether the interaction of intrinsic and extrinsic components exceeds the size of effects on health attributable to single components. Results based on 51 reports document an independent explanatory role of “over-commitment” in explaining workers’ health in a majority of studies. However, support in favour of the interaction hypothesis is limited and requires further exploration. In conclusion, the findings of this review support the usefulness of a work stress model that combines extrinsic and intrinsic components in terms of scientific explanation and of designing more comprehensive worksite stress prevention programs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Associations of Extrinsic and Intrinsic Components of Work Stress with Health: A Systematic Review of Evidence on the Effort-Reward Imbalance Model

Siegrist

2016

IJERPH

185

216

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“…Participants with high effort-reward imbalance exhibited a significantly stronger increase in CRP under acute laboratory stress compared to those with low levels of work stress [ 91 ]. In two cross-sectional studies, one conducted among 204 Jordanian men [ 69 ] and one conducted in 731 working men and women in China [ 92 ], CRP was significantly associated with ERI, and in China additionally with over-commitment. More recently, baseline screening data from a large cohort of working men and women in France ( N = 43,593) were analysed where high ERI was associated with higher white blood cell counts—a marker of increased low-grade systemic inflammation—both among men and women [ 93 ].…”

Section: Resultsmentioning

confidence: 99%

Work Stress and Altered Biomarkers: A Synthesis of Findings Based on the Effort–Reward Imbalance Model

Siegrist

2017

IJERPH

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While epidemiological studies provide statistical evidence on associations of exposures such as stressful work with elevated risks of stress-related disorders (e.g., coronary heart disease or depression), additional information on biological pathways and biomarkers underlying these associations is required. In this contribution, we summarize the current state of the art on research findings linking stressful work, in terms of an established theoretical model—effort-reward imbalance—with a broad range of biomarkers. Based on structured electronic literature search and recent available systematic reviews, our synthesis of findings indicates that associations of work stress with heart rate variability, altered blood lipids, and risk of metabolic syndrome are rather consistent and robust. Significant relationships with blood pressure, heart rate, altered immune function and inflammation, cortisol release, and haemostatic biomarkers were also observed, but due to conflicting findings additional data will be needed to reach a firm conclusion. This narrative review of empirical evidence supports the argument that the biomarkers under study can act as mediators of epidemiologically established associations of work stress, as measured by effort–reward imbalance, with incident stress-related disorders.

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“…Previous studies indicate that a number of factors affect job stress, including depression (14-16), personality type (17, 18), physical activity (19, 20), socioeconomic status (17, 21, 22), job satisfaction (23, 24), and demographic variables like age, education, and marital status (1, 17, 24-26). Given the importance of job stress, especially in staff personnel, there is an urgent need to study all related factors simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Job Stress and Related Factors Among Iranian Male Staff Using a Path Analysis Model

Azad-Marzabadi

Fesharaki

2016

Iran Red Crescent Med J

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BackgroundIn recent years, job stress has been cited as a risk factor for some diseases.ObjectivesGiven the importance of this subject, we established a new model for classifying job stress among Iranian male staff using path analysis.Materials and MethodsThis cross-sectional study was done on male staff in Tehran, Iran, 2013. The participants in the study were selected using a proportional stratum sampling method. The tools used included nine questionnaires (1- HSE questionnaire; 2- GHQ questionnaire; 3- Beck depression inventory; 4- Framingham personality type; 5- Azad-Fesharaki’s physical activity questionnaire; 6- Adult attachment style questionnaire; 7- Azad socioeconomic questionnaire; 8- Job satisfaction survey; and 9- demographic questionnaire).ResultsA total of 575 individuals (all male) were recruited for the study. Their mean (±SD) age was 33.49 (±8.9) and their mean job experience was 12.79 (±8.98) years. The pathway of job stress among Iranian male staff showed an adequate model fit (RMSEA=0.021, GFI=0.99, AGFI=0.97, P=0.136). In addition, the total effect of variables like personality type (β=0.283), job satisfaction (β=0.287), and age (β=0.108) showed a positive relationship with job stress, while variables like general health (β=-0.151) and depression (β=-0.242) showed the reverse effect on job stress.ConclusionsAccording to the results of this study, we can conclude that our suggested model is suited to explaining the pathways of stress among Iranian male staff.

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High‐sensitivity CRP: Possible link between job stress and atherosclerosis

Abstract: High effort, overcommmitment, and ERI were positively associated with hs-CRP. Inflammation indicated by hs-CRP may be one of important mediators linking job stress and atherosclerosis.

Cited by 18 publications

References 37 publications

Associations of Extrinsic and Intrinsic Components of Work Stress with Health: A Systematic Review of Evidence on the Effort-Reward Imbalance Model

Associations of Extrinsic and Intrinsic Components of Work Stress with Health: A Systematic Review of Evidence on the Effort-Reward Imbalance Model

Work Stress and Altered Biomarkers: A Synthesis of Findings Based on the Effort–Reward Imbalance Model

Job Stress and Related Factors Among Iranian Male Staff Using a Path Analysis Model

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