High-sensitivity C-reactive protein predicts adverse cardiovascular events in patients with Takayasu arteritis with coronary artery involvement

Abstract

The study aimed to assess the association of high-sensitivity C-reactive protein (hsCRP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) to major adverse cardiovascular events (MACE) in Takayasu arteritis (TA) patients with coronary artery disease (CAD). Data on 60 TA patients with CAD and 60 age- and severity-matched patients with CAD hospitalized in Fuwai Hospital from 2005 to August 2014 were assessed. The clinical features, laboratory data, coronary angiographic findings, treatment, and follow-up outcomes were summarized retrospectively. MACE were defined as death from cardiac causes, myocardial infarction, nonfatal target vessel revascularization, or rehospitalization due to unstable or progressive angina. CAD patients had more atherogenic lipid and lipoprotein profiles such as lower levels of high-density lipoprotein cholesterol (HDL-C) (1.0 ± 0.2 vs. 1.3 ± 0.3 mmol/L, p = 0.01) and higher levels of low-density lipoprotein cholesterol (LDL-C) (2.5 ± 0.9 vs. 2.2 ± 1.1 mmol/L, p = 0.04) in contrast with TA-CAD patients. During a mean follow-up period of 3.2 years, 31 patients with Takayasu coronary arteritis reached the endpoint. Multivariate Cox proportional hazards model demonstrated that log(hsCRP) (HR = 5.3, 95 % CI = 1.1-27.8, p = 0.04) was a significant and independent predictor of MACE in patients with Takayasu coronary arteritis. Elevated baseline levels of hsCRP predict cardiovascular events, independent of other prognostic markers in TA-related CAD patients.

Hemographic indices are associated with mortality in acute heart failure

“…Such findings were in accord with Wang et al . that hsCRP was a prognostic factor only in patients with Takayasu arteritis if CAD was presented 40 . The study results may support that inflammation was a significant risk factor for mortality in AHF with various characteristics, especially in the subjects with CAD and reduced LVEF.…”

Management of Takayasu arteritis: a systematic literature review informing the 2018 update of the EULAR recommendation for the management of large vessel vasculitis

“…In one case–control study (n=120), high-sensitivity CRP was a significant predictor of major cardiac events 30. Adding to cardiovascular risk, patients with TAK present a more atherogenic lipid profile when compared with healthy controls, but not when compared with coronary artery disease controls 26 30…”

Predictors of cardiovascular complications in patients with Takayasu’s arteritis: results of a retrospective study and analysis of autopsy materials

“…В другой когорте больных АТ факторами повышенного сосудистого риска оказались анемия и низкая масса тела [9]. Удобным маркером оценки риска оказался высокий уровень С-реактивного белка [10]. В ряде случаев повышенный риск тромбозов при АТ ассоциировался с наличием волчаночного антикоагулянта и повышенной функцией тромбоцитов [11,12].…”