High Sensitivity C-Reactive Protein Predictive Value for Cardiovascular
                        Disease: A Nested Case Control from Isfahan Cohort Study (ICS)

Koosha, Pooya; Roohafza, Hamidreza; Sarrafzadegan, Nizal; Vakhshoori, Mehrbod; Talaei, Mohammad; Sheikhbahaei, Erfan; Sadeghi, Masoumeh

doi:10.5334/gh.367

Cited by 24 publications

(19 citation statements)

References 37 publications

(52 reference statements)

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“…However, there are only a few studies investigating the serum levels of these cytokines and their results are conflicting. Hs‐CRP is a very sensitive marker of systemic inflammation and is the most widely evaluated biomarker for CVD risk prediction 38 . In this study, we report higher serum IL‐1β, IL‐6, TNF‐α, and hs‐CRP levels in patients with rosacea compared with the control group.…”

Section: Discussionsupporting

confidence: 50%

Carotid intima‐media thickness and serum proinflammatory cytokine levels in rosacea patients without cardiovascular risk factors

Ertekin

Aksu²,

Koçyiğit

et al. 2021

Dermatologic Therapy

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There is a growing body of evidence linking rosacea to various systemic disorders, even though data regarding the association between rosacea and cardiovascular diseases are presently controversial. We sought to investigate the potential association of rosacea with subclinical atherosclerosis and serum proinflammatory/proatherogenic markers. This study included 44 patients with rosacea and 44 age‐matched and sex‐matched healthy control subjects. Patients with traditional cardiovascular risk factors or a history of cardiovascular events were excluded. Demographic, clinical, and laboratory data, including serum interleukin‐1 beta (IL‐1β), interleukin‐6 (IL‐6), tumor necrosis factor‐alpha (TNF‐α), and high‐sensitivity C‐reactive protein (hs‐CRP) levels were assessed. Carotid intima‐media thickness (CIMT) and carotid plaques were measured by carotid ultrasonography. Serum IL‐1β (P < .001), IL‐6 (P < .001), TNF‐α (P < .001), and hs‐CRP (P < .001) levels were significantly higher in the patient group compared with the control group. Mean CIMT values did not differ significantly between the patient group and control group (P > .05). Patients with moderate to severe rosacea had a significantly greater CIMT than those with mild rosacea (P = .047). Rosacea patients with eye involvement had a significantly greater CIMT than those without eye involvement (P = .008). There was no significant correlation between CIMT values and inflammation parameters. As conclusion, in the absence of other traditional cardiovascular risk factors, rosacea does not seem to affect mean CIMT value. However, specific subgroups such as patients with moderate to severe disease or with eye involvement are associated with increased subclinical atherosclerosis and may require additional attention for cardiovascular disease prevention.

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Section: Discussionsupporting

confidence: 50%

Carotid intima‐media thickness and serum proinflammatory cytokine levels in rosacea patients without cardiovascular risk factors

Ertekin

Aksu²,

Koçyiğit

et al. 2021

Dermatologic Therapy

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“…An appropriate approach toward HF management requires knowledge of mechanisms and precipitating factors contributing to its development [ 5 ]. Recently, biomarkers have been introduced to help physicians predicting clinical outcomes and improve the current knowledge about the precise pathophysiology of cardiovascular disorders, including HF [ 6 – 8 ]. Some of these biomarkers' prognostic values have been extensively investigated over the past decades [ 7 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

The association between platelet-to-lymphocyte ratio with mortality among patients suffering from acute decompensated heart failure

Heidarpour

Bashiri

Vakhshoori

et al. 2021

BMC Cardiovasc Disord

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Background Platelet-to-lymphocyte ratio (PLR) is an inflammation index suggested to have the prognostic capability in heart failure (HF). We sought to investigate the association of PLR with cardiovascular disease (CVD) mortality and creatinine (Cr) rise among Iranian individuals suffering from acute decompensated HF (ADHF). Methods This retrospective cohort study was in the context of the Persian Registry Of cardioVascular diseasE/Heart Failure (PROVE/HF) study. 405 individuals with ADHF admitted to the emergency department were recruited from April 2019 to March 2020. PLR was calculated by division of platelet to absolute lymphocyte counts and categorized based on quartiles. We utilized the Kaplan–Meier curve to show the difference in mortality based on PLR quartiles. Cr rise was defined as the increment of at least 0.3 mg/dl from baseline. Cox proportional hazard ratio (HR) was used to investigate the association of PLR with CVDs mortality. Results Mean age of participants was 65.9 ± 13.49 years (males: 67.7%). The mean follow-up duration was 4.26 ± 2.2 months. CVDs mortality or re-hospitalization was not significantly associated with PLR status. Multivariate analysis of PLR quartiles showed a minimally reduced likelihood of CVDs death in 2nd quartile versus the first one (HR 0.40, 95% confidence interval (CI) 0.16–1.01, P = 0.054). Cr rise had no remarkable relation with PLR status in neither model. Conclusion PLR could not be used as an independent prognostic factor among ADHF patients. Several studies are required clarifying the exact utility of this index.

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“…Future multi-center, large sample-size studies with long-term follow-up regarding the medical and socio-economic effects of CRP-guided interventions may be helpful. Since hsCRP is more sensitive to be quantified with a low detect threshold, 31 it might act as a more valuable biomarker than CRP in the clinical risk-stratification and prognostic prediction model.…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein predicts early clinical outcomes and long-term mortality after left ventricular assisted device

et al. 2022

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Objectives: Left ventricular assist device (LVAD) implantation has become a reliable therapeutic strategy in patients with advanced heart failure. C-reactive protein (CRP) is a well-established biomarker of inflammation. This study aims to determine the prognostic effect of CRP level on clinical outcomes of patients who undergo LVAD implantation. Methods: This is a single-center, observational, retrospective study. One hundred fifty-three patients who received continuous-flow LVAD implantation were included and were divided into two groups of high (>3.9 mg/dL) versus low CRP (⩽3.9 mg/dL). Results: Patients with high pre-implant CRP levels were prone to severe preoperative clinical conditions and complicated intraoperative procedures. Compared with patients in the low CRP group, elevated pre-implant CRP was associated with increased hospital mortality (31.4% vs 8.4%, p < 0.001), postoperative right ventricular failure (47.1% vs 30.1%, p = 0.031), right ventricular assist device use (34.3% vs 16.9%, p = 0.013), AKI (70% vs 51.8%, p = 0.022) and significantly prolonged duration of postoperative mechanical ventilation and intensive care unit length of stay. Univariate Cox regression showed that high pre-implant CRP was significantly associated with increased risk of long-term mortality (Hazard ratio (HR) 2.632 95%; CI: 1.657–4.183, p < 0.001), and multivariable Cox regression also revealed the higher risk of long-term mortality in patients with elevated pre-implant CRP (HR, 2.848 95%CI: 1.659–4.888, p < 0.001). These results remained stable when treating pre-implant CRP as a continuous variable. Besides, the prognostic effect of post-implant CRP was also observed. Conclusions: CRP is a reliable risk-stratification biomarker in patients receiving continuous-flow -LVAD and can be used as a predictor for short- and long-term outcomes.

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High Sensitivity C-Reactive Protein Predictive Value for Cardiovascular Disease: A Nested Case Control from Isfahan Cohort Study (ICS)

Cited by 24 publications

References 37 publications

Carotid intima‐media thickness and serum proinflammatory cytokine levels in rosacea patients without cardiovascular risk factors

Carotid intima‐media thickness and serum proinflammatory cytokine levels in rosacea patients without cardiovascular risk factors

The association between platelet-to-lymphocyte ratio with mortality among patients suffering from acute decompensated heart failure

C-reactive protein predicts early clinical outcomes and long-term mortality after left ventricular assisted device

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