High-sensitivity C-reactive protein may be an indicator of the development of atherosclerosis in myocardial bridging

Duygu, Hamza; Zoghi, Mehdi; Nalbantgil, Sanem; Özerkan, Filiz; Çakır, Çayan; Ertaş, Faruk; Yüksek, Ümit; Akilli, Azem; Akın, Mustafa; Ergene, Oktay

doi:10.1016/j.ijcard.2006.12.046

Cited by 14 publications

(8 citation statements)

References 11 publications

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“…This significant association is also supported not only by an autopsy study, 13 but also by the fact that the incidence of MI was significantly higher in patients with MB with severe stenosis at systole. 40 Thus, further therapeutic strategy may be necessary for patients with long and/or thick MB. In addition, a long-term follow-up study of patients with MB on LAD will elucidate the accurate cut-off values of MB length and thickness predisposing to MI.…”

Section: Resultsmentioning

confidence: 99%

Anatomical Characteristics of Myocardial Bridge in Patients With Myocardial Infarction by Multi-Detector Computed Tomography

Takamura

Fujimoto

Nanjo

et al. 2011

Circ J

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Background: Recent development of multi-detector computed tomography (MDCT) has made the detection of myocardial bridge (MB) easier on the left anterior descending coronary artery (LAD). The LAD segment proximal to the MB is well known to be susceptible to atherosclerosis. Anatomical characteristics of MB on LAD in patients with myocardial infarction (MI) were examined by MDCT. Methods and Results:Subjects were 43 MI patients who had MB in the LAD and comprised 2 groups: 14 with culprit lesions in the LAD proximal to MB (culprit group) and 29 without culprit lesions in the LAD (non-culprit group). MB length, MB thickness, and the distance from the orifice of left main trunk (LMT) to MB entrance were compared. Age and coronary risk factors showed no significant difference between the 2 groups. MB length (P=0.011), MB thickness (P=0.035), and index of the length multiplied by thickness of MB (P=0.031) were significantly greater in the culprit group. The distance from the orifice of the LMT to MB entrance was significantly shorter in the culprit group (P=0.006).Conclusions: Anatomical properties of MB, such as length and thickness of MB as well as MB location, are associated with the formation of culprit lesions of LAD proximal to MB in MI. (Circ J 2011; 75: 642 - 648)

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Section: Resultsmentioning

confidence: 99%

Anatomical Characteristics of Myocardial Bridge in Patients With Myocardial Infarction by Multi-Detector Computed Tomography

Takamura

Fujimoto

Nanjo

et al. 2011

Circ J

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“…It is unclear how these factors relate to symptom occurrence, however it elevated CRP and reduced eGFR may cause endothelial dysfunction [37,38], leading to changes in intracoronary plaque composition, which is difficult to accurately assess on CAG [39,40]. CRP increases atherosclerotic changes at MB segments [41]. Thus, it is possible that these factors contribute to the occurrence of exercise-induced myocardial ischemia in VSA patients.…”

Section: Discussionmentioning

confidence: 99%

What Factors Contribute to Chest Symptoms during Exercise in Patients with Vasospastic Angina?

Teragawa¹,

Fujii²,

Oshita³

et al. 2017

Angiol

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Objective: Chest symptoms in patients with vasospastic angina (VSA) typically occur during rest. However, we have occasionally experienced patients with VSA who have had chest symptoms even during exercise. However, factors contributing to the chest symptoms during exercise in patients with VSA remain unclear. Therefore, we investigated this relationship. Methods:We investigated 101 patients with VSA (median age: 69 years, 51 males and 50 females). We completed detailed chest symptom examinations at rest (n=85), during exercise (n=2), and both at rest and during exercise (n=14). Patients were divided into the two groups: Group I consisted of patients with VSA whose chest symptoms occurred only at rest (n=85, 84%) and Group II consisted of patients with VSA whose chest symptoms occurred during exercise (n=16, 16%). On a coronary angiography, the presence of atherosclerosis (% stenosis>25%), significant coronary stenosis (% stenosis>50%), and myocardial bridging (MB), defined as the narrowing of the coronary artery during systole, were checked. Clinical parameters, including angiographic findings, were assessed in the two groups.Results: There were no significant differences in coronary risk factors between the two groups. The presence of atherosclerosis (Group I: 58% vs. group II: 75%) and significant coronary stenosis (Group I: 10% vs. group II: 25%) did not differ between-groups. The presence of MB was significantly higher in Group II (50%) than in Group I (12%, p=0.0002). Logistic regression analysis showed that the presence of MB was associated with patients in Group II.Conclusions: MB, rather than coronary atherosclerosis or significant coronary stenosis, may contribute to chest symptoms during exercise in patients with VSA.

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“…29 Duygu et al found the existence of low-grade inflammation in patients with MB and atherosclerotic disease and claimed that high sensitive C reactive protein could be used as a marker for atherosclerotic development in MB patients. 30 In a study by Yıldız et al, the relationship between NLR and MB was investigated by comparing the hematological parameters of 71 patients with MB and 101 patients with normal coronary artery, obtained by automatized blood counter. No statistically significant difference was found between the groups in respect of hemoglobin, platelet count, glucose level and creatinine.…”

Section: Discussionmentioning

confidence: 99%

The relationship between neutrophil to lymphocyte ratio and myocardial bridge

2016

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High-sensitivity C-reactive protein may be an indicator of the development of atherosclerosis in myocardial bridging

Cited by 14 publications

References 11 publications

Anatomical Characteristics of Myocardial Bridge in Patients With Myocardial Infarction by Multi-Detector Computed Tomography

Anatomical Characteristics of Myocardial Bridge in Patients With Myocardial Infarction by Multi-Detector Computed Tomography

What Factors Contribute to Chest Symptoms during Exercise in Patients with Vasospastic Angina?

The relationship between neutrophil to lymphocyte ratio and myocardial bridge

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