High sensitivity C-reactive protein as a prognostic marker in ischaemic and haemorrhagic stroke

Lal, Ritesh; Gupta, Abhishek; Virmani, S. K.; Tyagi, V. K.; Sharma, Shruti

doi:10.18203/2349-3933.ijam20161094

Cited by 3 publications

(5 citation statements)

References 15 publications

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“…This suggests that higher hsCRP levels are associated with severe neurological deficit and thus worse outcome. Similar findings were obtained in the study by Pinky Talreja Mishra, (11) Jayachandra et al, (15) Ritesh Lal et al (18) and Davinder Singh Rana et al, (14) In the study by Ritesh Lal et al, (18) stroke patients were classified on the basis of Scandinavian Stroke Scale into minor, moderate and severe stroke. Patients with minor stroke had lower hsCRP values as compared to patients with severe stroke.…”

Section: Discussionsupporting

confidence: 78%

“…These findings are similar to the findings of Pinky Talreja Mishra et al (11) and Jayachandra et al (15) Thus higher hsCRP levels in haemorrhagic stroke suggest a more severe inflammatory response. However, these findings are in contradiction to findings of Yoshiyuki Wakugawa et al in the Hisayama study (17) and Ritesh Lal et al (18) In the study by Yoshiyuki Wakugawa et al, (17) high hsCRP levels were found to be an independent risk factor for ischemic stroke in men but not for haemorrhagic stroke in either men or women. In the study by Ritesh Lal et al, (18) mean hsCRP levels in ischemic stroke were higher than in haemorrhagic stroke.…”

Section: Discussioncontrasting

confidence: 65%

“…However, these findings are in contradiction to findings of Yoshiyuki Wakugawa et al in the Hisayama study (17) and Ritesh Lal et al (18) In the study by Yoshiyuki Wakugawa et al, (17) high hsCRP levels were found to be an independent risk factor for ischemic stroke in men but not for haemorrhagic stroke in either men or women. In the study by Ritesh Lal et al, (18) mean hsCRP levels in ischemic stroke were higher than in haemorrhagic stroke. This may be due to presence of some confounding factors like obesity, elderly age or due to large size of bleed in our study secondarily leading to ischemia and increasing hsCRP.…”

Section: Discussioncontrasting

confidence: 65%

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High Sensitivity C- Reactive Protein Level in Acute Cerebrovascular Accident (Stroke) at a Tertiary Care Centre

Bhaisare¹,

Jog²,

Rao³

et al. 2020

jemds

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BACKGROUNDStroke is the leading cause of death worldwide and one of the main causes of long term disability. According to WHO, 15 million suffer from stroke each year. Studies have shown that levels of hsCRP measured shortly after stroke predicted complimentary aspects of prognosis. There is possibility that elevated hsCRP levels has direct relation to extent of cerebral tissue injury. We wanted to measure the levels of hsCRP in acute cerebrovascular accident. To correlate the level of hsCRP with severity of stroke and outcome. METHODSStudy was conducted in patients admitted in medical ward and medical ICU in tertiary care hospital (Grant Government Medical College and Sir JJ Group of Hospitals). It was a cross sectional study. A total of 150 patients who presented with stroke and fulfilled inclusion and exclusion criteria were enrolled in the study. In all patients hsCRP levels were measured within 48 hours of admission. Data was collected prospectively in a Microsoft Excel database. Statistical analysis was done using non-parametric ANOVA (Kruskal Wallis test) and Mann Whitney test. RESULTSMean age of patients was 59  12 years. hsCRP levels were raised in stroke patients. Also values were found to be more in haemorrhagic stroke (value) than in ischemic stroke (value) and the difference was found to be significant. Significant correlation was also found between hsCRP levels and GCS with lower GCS scores associated with higher hsCRP levels in both types of stroke. Mean hsCRP level in survivors was 21.83  23.17 mg/L and in non survivors was 82.07  25.83 mg/L and the difference was statistically significant (p <0.0001) CONCLUSIONSWe concluded that hsCRP level is increased in cases of stroke (both ischemic and haemorrhagic) suggesting an inflammatory response in acute stroke. Increased levels of hsCRP correlated with severity of neurological deficit and worse outcome.

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Section: Discussionsupporting

confidence: 78%

Section: Discussioncontrasting

confidence: 65%

Section: Discussioncontrasting

confidence: 65%

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High Sensitivity C- Reactive Protein Level in Acute Cerebrovascular Accident (Stroke) at a Tertiary Care Centre

Bhaisare¹,

Jog²,

Rao³

et al. 2020

jemds

View full text Add to dashboard Cite

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“…This was similar to the study conducted by Yoshiyuki Wakugawa et al 20 Estrogen is postulated to have a modulating effect over response to atherosclerosis and injury which may possibly account for this. 29 There was no statistical significance between the two types of stroke (p = 0.456) in contrast to research done by Lal R et al 30 Prevalence of ischemic stroke among men was higher than hemorrhagic type, 75.9% vs 69.6% while among women, the prevalence of hemorrhagic type was higher (30.4%) compared to ischemic type (24.1%).…”

Section: Discussionmentioning

confidence: 63%

“…Ritesh Lal et al, showed a similar prognostic correlation using the Scandinavian stroke scale. 30 The Bergen stroke study, also reported a similar result which showed that higher hs-CRP level was associated with higher stroke severity and mortality. 32 Study by Elkind et al, concluded that hs-CRP which is an acute phase reactant is elevated in more severe stroke and can be associated with mortality.…”

Section: Discussionmentioning

confidence: 77%

High sensitivity C-reactive protein level in cerebrovascular accident

Kumar¹,

Vidya

2020

Int J Adv Med

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Background: Stroke is the second leading cause of death worldwide according to WHO. High sensitivity C-Reactive Protein (hs-CRP) is an acute phase reactant which is being studied extensively to delineate its role in development of stroke as well as in prognostication. This study was done to assess correlation of hs-CRP with risk factors of stroke and its association with types of stroke and prognosis.Methods: A prospective case control study of 100 patients with acute stroke along with 100 controls was conducted with informed consent. At baseline, hs-CRP levels were measured and Modified Rankin Scale (MRS) was assessed. On day 90 the Modified Rankin Scale was assessed again. Patients were divided into groups based on hs-CRP levels and MRS and the results were analysed.Results: Prevalence of stroke was more in men than women (p=0.0002). Statistically significant difference was found between mean hs-CRP levels in men (4.722±0.8982 mg/L) and women (4.133±0.9446 mg/L) (p=0.005) and between cases and controls (p=0.0003). There was no significant association with type of stroke (p=0.456). Mean total cholesterol levels between cases and controls showed statistically significant difference (p=0.0005). High MRS was significantly associated with high hs-CRP levels (p=0.003). Higher hs-CRP on day 1 correlated with higher MRS on day 90.Conclusions: hs-CRP level is increased in stroke and shows significant association with severity of stroke and prognosis.

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Study of C-Reactive Protein Level in Acute Cerebrovascular Accidents

Gupta¹,

Gupta

Gupta³

et al. 2023

IJAR

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BACKGROUND Stroke is a major cause of death and physical, mental, psychological morbidity worldwide. According to WHO, about 15 million peoples suffer from stroke each year. C- reactive protein (CRP) is a major acute phase protein in humans. The levels of CRP have been found to be raised in atherothrombotic diseases and related to plaque formation. This study was done to assess the levels of CRP (hs-CRP) in various types of stroke patients, and to predict the severity and prognosis. METHODS Study was conducted in 90 patients admitted in LLR and associated hospitals, G.S.V.M. medical college Kanpur. All patients of stroke fullling the Inclusion and exclusion criteria were enrolled in the study. Serum CRP (hs-CRP) was measured by Turbidimetric immunoassay. Statistical analysis was done by using T test and chi square test. Our patients were mostly in the age group of 40-79 RESULTS years with mean age 59 year. Patients were mostly males. hsCRP levels were found to be raised statistically signicant in all types of stroke patients as compared to controls. There was signicant rise from rst day to third day (P<0.05). CRP was maximum in patients of cerebral infarction as compared to other types of stroke. Mean CRP of expired patients was higher as compared to whole study group (P<0.05). CONCLUSIONS We concluded that hsCRP level elevation is common in stroke patients and its evaluation could be an important prognostic parameter in stroke patients

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High sensitivity C-reactive protein as a prognostic marker in ischaemic and haemorrhagic stroke

Cited by 3 publications

References 15 publications

High Sensitivity C- Reactive Protein Level in Acute Cerebrovascular Accident (Stroke) at a Tertiary Care Centre

High Sensitivity C- Reactive Protein Level in Acute Cerebrovascular Accident (Stroke) at a Tertiary Care Centre

High sensitivity C-reactive protein level in cerebrovascular accident

Study of C-Reactive Protein Level in Acute Cerebrovascular Accidents

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