2017
DOI: 10.1093/geroni/igx004.2890
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High-Sensitivity C-Reactive Protein and Risks of All-Cause and Cause-Specific Mortality in Japan

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Cited by 8 publications
(22 citation statements)
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“…Similar results were shown in the EPIC-Norfolk study in which the association between elevated CRP levels and all-cause mortality was apparent in all men, but only in those women with the highest levels of the CRP distribution [19]. Although CRP levels are lower in Japanese subjects compared with Western ones, CRP was an independent predictor of all-cause mortality in apparently healthy Japanese men but not women [20]. The reason for this gender diff erence needs to be elucidated.…”
Section: Discussionsupporting
confidence: 74%
“…Similar results were shown in the EPIC-Norfolk study in which the association between elevated CRP levels and all-cause mortality was apparent in all men, but only in those women with the highest levels of the CRP distribution [19]. Although CRP levels are lower in Japanese subjects compared with Western ones, CRP was an independent predictor of all-cause mortality in apparently healthy Japanese men but not women [20]. The reason for this gender diff erence needs to be elucidated.…”
Section: Discussionsupporting
confidence: 74%
“…It is also important to note that sex was not a modifier in our study. Some studies showed a positive association in both sexes [8,23], while significant differences appeared to exist in a single sex (mostly male [27,40,41]). However, whether males or females are at a greater risk remains controversial [8,23,41,42].…”
Section: Discussionmentioning
confidence: 99%
“…CRP, an acute-phase protein produced predominantly by hepatocytes, is a sensitive and exquisitely systemic marker of inflammation [9]. CRP has been commonly assayed for infections [10], in-hospital complications [11], prognosis influences [12] and aging-related health outcomes in clinical applications, especially cardiovascular and metabolic disease risk [13,14].Higher CRP levels have been proposed as a predictor of all-cause mortality in many [15][16][17][18][19][20][21][22][23][24][25][26] but not all studies [27].…”
Section: Introductionmentioning
confidence: 99%
“…Numerous studies have investigated the associations between hsCRP concentrations and mortality. For instance, recently, elevated hsCRP concentrations were shown to be associated with the risk of all-cause mortality in both men and women in many [69], but not all studies [10]. Two other prospective studies were conducted in the United States and indicated that high CRP levels were associated with significantly increased risks of all-cause and CVD-related mortality [11, 12].…”
Section: Introductionmentioning
confidence: 99%
“…However, findings regarding the effect of hsCRP concentrations on cancer mortality remain controversial. Several studies have suggested that an increased risk of cancer mortality is associated with elevated hsCRP concentrations [9, 10, 1316]. In contrast, a recent prospective study failed to identify a similar association [17].…”
Section: Introductionmentioning
confidence: 99%