High-sensitivity C-reactive protein affects central haemodynamics and augmentation index in apparently healthy persons

Kampus, Priit; Kals, Jaak; Ristimäe, Tiina; Fischer, Krista; Zilmer, Mihkel; Teesalu, Rein

doi:10.1097/00004872-200406000-00014

Cited by 63 publications

(58 citation statements)

References 41 publications

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“…Chronic coffee consumption is associated with increased inflammatory markers (Zampelas et al, 2004), denoting lowgrade inflammation. Despite the fact that acute inflammation decreases wave reflections (Vlachopoulos et al, 2005b), chronic low-grade inflammation has been linked to enhanced wave reflections in some studies (Kampus et al, 2004;Kullo et al, 2005;Mahmud and Feely, 2005). In our study, however, we found no association between coffee consumption and hsCRP, a finding that clearly deserves further investigation.…”

Section: Mechanismscontrasting

confidence: 87%

Effect of chronic coffee consumption on aortic stiffness and wave reflections in hypertensive patients

Alexopoulos

et al. 2006

Eur J Clin Nutr

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Objective: Aortic stiffness and wave reflections are important markers and prognosticators of cardiovascular risk. Caffeine increases acutely aortic stiffness and wave reflections. Furthermore, chronic coffee consumption is associated with increased aortic stiffness and wave reflections in normotensive subjects. In the present study, we aimed to assess the association between chronic coffee consumption, and aortic stiffness and wave reflections in hypertensive patients. Design: Epidemiological survey. Setting: Hypertension Unit, University Hospital. Subjects-methods: We examined 259 never-treated hypertensives (age 50712 years, 165 males) without diabetes mellitus, who were asked to describe in detail the type and amount of coffee they consumed. Carotid-femoral pulse wave velocity (PWV) and augmentation index (AIx) were measured non-invasively as indices of aortic stiffness and wave reflections, respectively. Results: When controlled for gender, age, height, smoking status, heart rate, mean pressure, HDL cholesterol and hsCRP, AIx was found to be higher with increasing daily coffee consumption. Post hoc analysis revealed that all groups of coffee consumption had higher AIx compared to no-consumption. PWV did not differ among groups of daily coffee consumption. Each participant had 35% higher relative risk of having high AIx for each cup (150 ml) of coffee per day, and 40% higher relative risk for each 10 cup-years. Conclusions: Coffee consumption is associated with increased wave reflections, but not aortic stiffness in never-treated hypertensive patients. This finding may have important clinical implications for cardiovascular health in hypertensive subjects. Sponsorship: None.

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Section: Mechanismscontrasting

confidence: 87%

Effect of chronic coffee consumption on aortic stiffness and wave reflections in hypertensive patients

Alexopoulos

et al. 2006

Eur J Clin Nutr

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“…Indeed, IBD patients are carriers of a significant inflammatory background, as shown by altered level of CRP, and the pivotal role of inflammation in the onset of atherosclerosis has been confirmed by previous studies, and has been also correlated with the level of proinflammatory cytokines [36,37]. In addition, it has been also reported that high levels of such cytokines, selectins and adhesion molecules were strongly related to the "markers" of arterial stiffness in patients suffering from cerebrovascular events [37,38]. Taken together, these data suggest that inflammation not only is strictly related to markers of arterial stiffness, but also is responsible of the raised atherogenic risk of these patients and, thus of cardio and cerebrovascular events in long-term exposed subjects.…”

Section: Discussionmentioning

confidence: 64%

Increased expression of markers of early atherosclerosis in patients with inflammatory bowel disease

Cappello

Licata

Calvaruso

et al. 2017

European Journal of Internal Medicine

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Background & Aims:Recent studies documented an increased cardiovascular risk in patients with inflammatory bowel disease (IBD). Our study aimed at investigating the prevalence of intima-media thickness (IMT) of the carotid arteries and the arterial stiffness indices as markers of early atherosclerosis in young IBD patients. Methods: We recruited 68 consecutive IBD patients, and 38 matched healthy controls less than 45 years old (median age 31.6 ± 8.1 years). Clinical and demographic features, cardiovascular risk factors, history of cardiovascular events, concomitant therapies were registered on a dedicate database. Carotid IMT was evaluated by using high resolution B-mode ultrasonography. Arterial stiffness was assessed by measurement of carotidfemoral Pulse Wave Velocity (PWV) and Augmentation Index (AIx). Results: Total cholesterol (P b 0.013) and LDL-cholesterol (P b 0.019) levels were significantly lower in IBD patients compared to controls. Carotid IMT was higher in IBD than in controls (P b 0.047), but there was no statistically significant difference among Crohn's Disease (CD) and Ulcerative Colitis (UC) patients. Moreover, PWV and AIx were significantly higher in patients as compared to controls (P b 0.006 and P b 0.004 respectively). No medication seemed to affect vascular measurements, though stiffness parameters were significantly higher in patients treated with 5-ASA (11.9 (9.7) vs 18.2 (10.2), P b 0.021), suggesting a lack of efficacy of 5-ASA in protecting IBD patients from early atherogenesis. Conclusions: Young IBD patients show an increase in subclinical markers of atherosclerosis. Future studies need to address whether these markers result in an increased risk of cardiovascular events in these patient.

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“…Similarly, an independent relation between Table 3 Multiple linear regression b-coefficients and 95% confidence intervals, standardized b-coefficients and explained variance R 2 describing the association between CRP quintiles compared to lowest quintile as reference (independent variable) and PWV (dependent variable) Abbreviations: AIx, augmentation index; CIMT, carotid intima-media thickness; CRP, C-reactive protein; CVD, cardiovascular disease; DM, diabetes mellitus; HDL, high-density cholesterol; hs-CRP, high-sensitivity C-reactive protein; PWV, pulse wave velocity. CRP and AIx has been shown in 158 asymptomatic middle-aged individuals by Kampus and colleagues 11 . In addition, based on a study carried out in apparently healthy UK adults, Yasmin et al 17 noted CRP only to be related to PWV.…”

Section: Discussionmentioning

confidence: 95%

“…9 PWV and AIx have been found to be elevated in patients with active arteritis. 10 Although some studies in healthy subjects also suggest a relationship between CRP and arterial stiffness measured by PWV or arterial wave reflections measured by AIx 11,12, other studies do not. 13 This study was, therefore, conducted to determine the association of serum hs-CRP levels with carotid-femoral PWV and radial AIx in a population-based sample of men living independently.…”

Section: Introductionmentioning

confidence: 99%

C-reactive protein and aortic stiffness and wave reflection in middle-aged and elderly men from the community

et al. 2007

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High plasma C-reactive protein (hs-CRP) levels and arterial stiffness are risk factors for cardiovascular diseases. Pulse wave velocity (PWV) and augmentation index (AIx) have been found to be elevated in patients with vascular inflammation, diabetes mellitus, hypertension, hypercholesterolemia and in smokers. We investigated the relation of high-sensitivity CRP (hs-CRP) with aortic stiffness in 362 men. The levels of hs-CRP were measured using a nephelometric method. Aortic PWV and AIx were assessed from carotid-femoral segment and radial artery waveforms with the use of the SphygmoCor device. In the crude model, aortic PWV increased significantly with increasing serum hs-CRP levels; PWV increased by 2.48 m/s (95% CI 1.58; 3.38) in the fifth compared to the first quintile of hs-CRP. In the adjusted model, the PWV increased by 0.84 m/s (95% CI 0.13; 1.55) in the fifth quintile compared to the first quintile (P-value was 0.02). In the crude model, AIx increased significantly with increasing serum hs-CRP levels; AIx increased by 7.17% (95% CI 3.72; 10.62) in the fifth versus the first quintile. Adjusted for confounders, AIx remained 4.57% (95% CI 1.32; 7.82) higher in the fifth compared to the first quintile (P-value for trend was o0.01). More adjustment for subclinical atherosclerosis attenuated the b-coefficient for PWV (difference 0.71 m/s (95% CI 0.01; 1.41), but not for AIx (4.60% (95% CI 1.34; 7.85)). In summary, low-grade inflammation seems to be independently related to increase of aortic artery stiffness over and above traditional risk factors and atherosclerosis.

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High-sensitivity C-reactive protein affects central haemodynamics and augmentation index in apparently healthy persons

Cited by 63 publications

References 41 publications

Effect of chronic coffee consumption on aortic stiffness and wave reflections in hypertensive patients

Effect of chronic coffee consumption on aortic stiffness and wave reflections in hypertensive patients

Increased expression of markers of early atherosclerosis in patients with inflammatory bowel disease

C-reactive protein and aortic stiffness and wave reflection in middle-aged and elderly men from the community

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