High Sensitivity C - Reactive Protein is Associated with Diastolic Dysfunction in Young African Americans without Clinically Evident Cardiac Disease

Rajaram, Venkataraman

doi:10.2174/1874192401105010188

Cited by 8 publications

(8 citation statements)

References 54 publications

(46 reference statements)

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“…In the general population, the triggers of DD progression to symptomatic stages include ischemia, arrhythmia, hypertension, or hospitalization, but are unknown in approximately 50% of the cases (37). One study of healthy individuals showed that DD was predicted by C‐reactive protein levels (41). Our systematic review identified an almost equal number of studies providing evidence for and against the role of disease duration and disease activity as predictors of DD (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Diastolic Dysfunction in Rheumatoid Arthritis: A Meta‐Analysis and Systematic Review

Aslam¹,

Bandeali²,

Khan³

et al. 2013

Arthritis Care & Research

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Objective. To determine if the prevalence of diastolic dysfunction is increased in rheumatoid arthritis (RA) patients. Methods. We conducted a time-and language-restricted literature search to identify studies conducted to compare echocardiographic parameters in patients with RA and controls. The mean difference for echocardiographic variables of interest was calculated using a random-effects model. A systematic review of the literature was performed.

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Section: Discussionmentioning

confidence: 99%

Diastolic Dysfunction in Rheumatoid Arthritis: A Meta‐Analysis and Systematic Review

Aslam¹,

Bandeali²,

Khan³

et al. 2013

Arthritis Care & Research

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“…However, IL-6 was not related to diastolic dysfunction in adolescent obesity. Hs-CRP has been shown to be associated with LV dysfunction in adult studies [9, 10]. Research showed that hs-CRP was related to plaque remodeling, oxidative stress, endothelial dysfunction, prothrombotic state, activation of complement, and vascular wall damage [39].…”

Section: Discussionmentioning

confidence: 99%

“…High-sensitivity C-reactive protein (hs-CRP) [9, 10], tumor necrosis factor-α (TNF-α) [11], and interleukin-6 (IL-6) [11, 12] have been reported as chronic inflammatory biomarkers associated with cardiac dysfunction in adults. M30 monoclonal antibody level can be used to reflect the degree of apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Serum apoptotic marker M30 is positively correlated with early diastolic dysfunction in adolescent obesity

Yang

Liu

et al. 2019

PLoS ONE

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Purpose Obesity in adolescence has been shown to be related to cardiac geometric and functional changes. Cardiac dysfunction in adults with obesity could be attributed to chronic low-grade inflammation, apoptosis of cardiomyocyte, and glucose metabolic disorder. The aforementioned association in adolescents with obesity have never been well studied. Our aim was to determine the types of cardiac dysfunction in adolescents with obesity and survey the association between cardiac dysfunction and chronic low-grade inflammation, apoptosis, and glucose dysregulation in adolescents with obesity. Methods Adolescents aged between 10 and 20 years were enrolled in this study. Body mass index, waist-to-hip ratio, blood pressure, glucose metabolism, and high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-α), and apoptosis marker M30 levels were measured. Echocardiographic indices were also measured. The association between serum biomarkers and echocardiographic function parameters was analyzed. Results Diastolic dysfunction was the major finding in the cardiac functional assessment. The main changes in glucose metabolism were elevated C-peptide level and insulin resistance. Hs-CRP, IL-6, and M30 levels also increased with adolescent obesity. M30 was the major biomarker that was highly correlated to diastolic dysfunction indices in adolescents with obesity. Conclusions Diastolic dysfunction was the main change in adolescent obesity. Insulin resistance, apoptotic marker M30, hs-CRP, and IL-6 were all elevated in adolescents with obesity. Only M30 was related to indices of left ventricular diastolic dysfunction among adolescents with obesity, rather than inflammation or insulin resistance.

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“…Serum hs-CRP was directly related to diastolic dysfunction (p=0.04, CI=1.07-10.5 (95%), Odds Ratio=3.36). Diastolic dysfunction is prevalent among African Americans and is independently related to the increased levels of hs-CRP 9 .…”

Section: Discussionmentioning

confidence: 99%

The Relationship between High Sensitive C-reaction Protein (hs-CRP) and Diastolic Heart Function in Diabetes Mellitus Type II

Ghavam¹,

Ahmadi²,

Mosavi³

et al. 2016

AJPRHC

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Among several inflammatory markers, high sensitive C-reaction protein (hs-CRP) is outstandingly observed in diabetic individuals. Serum hs-CRP is the main marker of inflammation whose levels independently predict the risk of cardiovascular events, and it has a prognostic value in heart patients. On the other hand, diabetes can lead to diastolic dysfunction of the heart. Diastolic dysfunction can cause symptoms of exertional dyspnea, which restricts the patient's activity. It is likely to predict diastolic dysfunction by screening through hs-CRP. The present investigation was a case-control study that was carried out on 52 patient diagnosed with diabetes mellitus type II. After the demographic data were recorded, and following the collection of data on the patients' history, physical examination, and para-clinical measures, individuals who had factors interfering with level of serum hs-CRP (kidney and liver diseases, inflammatory and infectious diseases, peripheral vascular disease, cerebrovascular disease, connective tissue disease, malignant tumor, trauma, consumption of statins, aspirin, ACEI, and fibrates) and diastolic dysfunction (ischemic heart disease, cardiomyopathies, pericardial disease, arrhythmias and valvular disease) were crossed out of the study. Serum hs-CRP was measured by nephelometry method. According to the results of tissue Doppler echocardiography, these patients are divided into two groups: one with diastolic dysfunction and the other without diastolic dysfunction. The serum hs-CRP levels of these patients were compared with each other. Among the participants, 30.8% were men and 69.2% were women, 36 individuals (69.2%) had diastolic dysfunction while 16 (30.8%) did not. There was a high level of correlation between the level of serumhs-CRP and diastolic dysfunction (p=0.02, t=2.36). The results of the present study indicated that there is a correlation between level of serum hs-CRP and diastolic dysfunction, such that the more the level of hs-CRP, the higher probability of diastolic dysfunction existence will be.

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High Sensitivity C - Reactive Protein is Associated with Diastolic Dysfunction in Young African Americans without Clinically Evident Cardiac Disease

Cited by 8 publications

References 54 publications

Diastolic Dysfunction in Rheumatoid Arthritis: A Meta‐Analysis and Systematic Review

Diastolic Dysfunction in Rheumatoid Arthritis: A Meta‐Analysis and Systematic Review

Serum apoptotic marker M30 is positively correlated with early diastolic dysfunction in adolescent obesity

The Relationship between High Sensitive C-reaction Protein (hs-CRP) and Diastolic Heart Function in Diabetes Mellitus Type II

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