High sensitivity and ultra-compact optical biosensor for detection of UREA concentration

Gharsallah, Zaineb; Najjar, Monia; Suthar, Bhuvneshwer; Janyani, Vijay

doi:10.1007/s11082-018-1520-2

Cited by 55 publications

(18 citation statements)

References 14 publications

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“…The process of biotin ling protein attachment to streptavidin would be used to study the interactions of the strongly sensitive proteins. Moreover, it is applied in biotechnology for detecting proteins [51]. It should be noted that the resulting streptavidin-biotin system shows the refractive index of 1.45.…”

Section: Resultsmentioning

confidence: 99%

High-Sensitivity Biosensor Based on Glass Resonance PhC Cavities for Detection of Blood Component and Glucose Concentration in Human Urine

et al. 2021

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In this work, a novel structure of an all-optical biosensor based on glass resonance cavities with high detection accuracy and sensitivity in two-dimensional photon crystal is designed and simulated. The free spectral range in which the structure performs well is about FSR = 630 nm. This sensor measures the concentration of glucose in human urine. Analyses to determine the glucose concentration in urine for a normal range (0~15 mg/dL) and urine despite glucose concentrations of 0.625, 1.25, 2.5, 5 and 10 g/dL in the wavelength range 1.326404~1.326426 μm have been conducted. The detection range is RIU = 0.2 × 10−7. The average bandwidth of the output resonance wavelengths is 0.34 nm in the lowest case. In the worst case, the percentage of optical signal power transmission is 77% with an amplitude of 1.303241 and, in the best case, 100% with an amplitude of 1.326404. The overall dimensions of the biosensor are 102.6 µm2 and the sensitivity is equal to S = 1360.02 nm/RIU and the important parameter of the Figure of Merit (FOM) for the proposed biosensor structure is equal to FOM = 1320.23 RIU−1.

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Section: Resultsmentioning

confidence: 99%

High-Sensitivity Biosensor Based on Glass Resonance PhC Cavities for Detection of Blood Component and Glucose Concentration in Human Urine

et al. 2021

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“…Another limitation of such sensors is the difficulty in obtaining a consistent signal while testing a complex biological media as well as the inability to be used in difficult to reach environments. Another type of widely studied biosensor is based on optical fibers, including grating-assisted (Lao et al, 2019;Sypabekova et al, 2019) and grating-free optical fibers (Sypabekova et al, 2020), photonic crystals (Gharsallah et al, 2018), resonators (Pongruengkiat and Pechprasarn, 2017) and interferometers (Liu et al, 2013) The first interest in optical fiber-based biosensors started with medical applications in the field of endoscopy and laser (Socorro-Leránoz et al, 2019). Since then, several studies showed that, by modifying the fiber structure (grating inscription, nanoparticle deposition, etching and tapering), it is also possible to detect binding events around the fiber.…”

Section: Optical Fiber Biosensors: Technological Aspectsmentioning

confidence: 99%

Perspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus Detector

Sypabekova

Tosi

Vangelista

2021

Front. Bioeng. Biotechnol.

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In time of COVID-19 biological detection technologies are of crucial relevance. We propose here the use of state of the art optical fiber biosensors to address two aspects of the fight against SARS-CoV-2 and other pandemic human coronaviruses (HCoVs). Fiber optic biosensors functionalized with HCoV spikes could be used to discover broadly neutralizing antibodies (bnAbs) effective against known HCoVs (SARS-CoV, MERS-CoV and SARS-CoV-2) and likely future ones. In turn, identified bnAbs, once immobilized onto fiber optic biosensors, should be capable to detect HCoVs as diagnostic and environmental sensing devices. The therapeutic and preventative value of bnAbs is immense as they can be used for passive immunization and for the educated development of a universal vaccine (active immunization). Hence, HCoV bnAbs represent an extremely important resource for future preparedness against coronavirus-borne pandemics. Furthermore, the assembly of bnAb-based biosensors constitutes an innovative approach to counteract public health threats, as it bears diagnostic competence additional to environmental detection of a range of pandemic strains. This concept can be extended to different pandemic viruses, as well as bio-warfare threats that entail existing, emerging and extinct viruses (e.g., the smallpox-causing Variola virus). We report here the forefront fiber optic biosensor technology that could be implemented to achieve these aims.

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“…[ 11–13 ] These properties of localized defect mode are used to design various devices such as optical filter, optical switch, sensor, DWDM etc. [ 12,14–21 ]…”

Section: Introductionmentioning

confidence: 99%

Graded Photonic Crystal as Improved Sensor for Nanobiophotonic Application

Suthar

Bissa²,

Bhargava³

2022

Macromolecular Symposia

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In the present communication, graded photonic crystal with defect layer is introduced to investigate a biosensor application. The study uses the well‐known transfer matrix method to calculate the transmission spectra. One‐dimensional photonic crystal with defect layer is used to obtain the sensitivity, quality factor, and figure of merit of the proposed device. The angular dependence of localized mode is used to improve the sensing parameters. The sensor parameters can be significantly improved with the graded thickness parameter for the proposed structure.

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High sensitivity and ultra-compact optical biosensor for detection of UREA concentration

Cited by 55 publications

References 14 publications

High-Sensitivity Biosensor Based on Glass Resonance PhC Cavities for Detection of Blood Component and Glucose Concentration in Human Urine

High-Sensitivity Biosensor Based on Glass Resonance PhC Cavities for Detection of Blood Component and Glucose Concentration in Human Urine

Perspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus Detector

Graded Photonic Crystal as Improved Sensor for Nanobiophotonic Application

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