High Sensitivity and Specificity of CA 19-9 for Pancreatic Carcinoma in Comparison to Chronic Pancreatitis. Serological and Immunohistochemical Findings

Safi, F.; Roscher, R.; Bittner, R.; Schenkluhn, B.; Döpfer, H.; Beger, H G

doi:10.1097/00006676-198707000-00006

Cited by 67 publications

(32 citation statements)

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“…In accordance with results reported by Safi et al [19], the preoperative CA19-9 level was higher in patients with distant metastasis. Nevertheless, the calculated standard deviation and standard error were too great to allow the use of this parameter as a preoperative selection method for patients likely to benefit from laparoscopy.…”

Section: Staging Of Pancreatic Carcinomasupporting

confidence: 92%

Diagnosing and Staging of Pancreatic Carcinoma – What Is Necessary?

Böttger¹,

Boddin²,

Düber

et al. 1998

Oncology

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The aim of the present prospective observational study was to diagnose and stage pancreatic carcinoma with a minimum of diagnostic procedures. Our experiences in 307 patients with a histologically confirmed pancreatic carcinoma show that for diagnosing pancreatic carcinoma sonography and computed tomography are sufficient in 95% of the cases. The combination of both has a sensitivity equal to that of endoscopic retrograde cholangiopancreatography (ERCP; 96.8 vs. 98.7%; n.s., χ² test). ERCP is only indicated in cases with negative sonography and computed tomography, and suspicion of pancreatic cancer. For tumor staging, the routine performance of angiography cannot be recommended in view of the fact that although it provides greater sensitivity for the evaluation of an infiltration of the portal vein (80% for angiography vs. 22% for sonography or computed tomography), it is associated with a lower positive predictive value (56.4 vs. 68 and 72%) which results in a lower accuracy. Despite recent advantages in diagnostic technology, less than 50% of unresectable tumors were identified preoperatively at a 10% false-positive rate. The major reason for unresectability is infiltration into the mesenteric axis, which cannot be identified laparoscopically. Laparoscopy or percutaneous biopsy is recommended only in the presence of a tumor with suspicion of distant metastasis detected by radiological imaging and requiring histological confirmation. In conclusion, sonography and computed tomography as the only diagnostic images are sufficient for diagnosing and staging of pancreatic carcinoma in more than 95% of the patients. Only a small number of patients needs further diagnostic procedures.

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Section: Staging Of Pancreatic Carcinomasupporting

confidence: 92%

Diagnosing and Staging of Pancreatic Carcinoma – What Is Necessary?

Böttger¹,

Boddin²,

Düber

et al. 1998

Oncology

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show abstract

“…Hyperbilirubinemia is also a significant confounding factor since it is associated with an increased CA 19-9 serum level in cases of both benign and malignant biliary obstruction [8,9,12,20]. Although CA 19-9 serum levels in the presence of obstructive jaundice may have higher sensitivity, it is at the cost of decreased specificity and accuracy.…”

Section: Limitations Of Ca 19-9 Serum Levels As a Pancreatic Cancer Bmentioning

confidence: 99%

“…Epigenetic silencing of the gene for 2→6 sialyl transferase during early stages of carcinogenesis leads to abnormal synthesis and accumulation of sialyl Lewis-a (CA . sLea may also play a role in cancer invasion/metastasis as it is known to be a ligand for endothelial cell E-selectin responsible for cell adhesion [8][9][10][11].…”

Section: Ca 19-9: Introductionmentioning

confidence: 99%

Serum CA 19-9 as a Biomarker for Pancreatic Cancer—A Comprehensive Review

Ballehaninna

Chamberlain

2011

Indian J Surg Oncol

211

161

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“…Epigenetic silencing of the gene for α 2→6 sialyltransferase during early stages of carcinogenesis leads to abnormal synthesis and accumulation of sialyl Lewis-a (CA 19-9) because decreases disialyl Lewis-a which is synthesized normally. (9)(10)(11)(12)(13) As shown in table 1 there was significance difference between cases and controls andthe mean CA 19-9 levels in controls was 14.6 ± 12.1, range was 0-59 U/ml and in cases 164.10 ± 217.35 U/ml and the p value was <0.001. Out of 30 controls the CA 19-9 levels, in 28 controls were <35 U/ml, in 2 controls >35 U/ml (but mildly elevated).…”

Section: Discussionmentioning

confidence: 93%

The importance of CA 19-9 in diagnosis and monitoring of Hepatobiliary and Gastrointestinal malignancies

Ali¹

2018

jmscr

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High Sensitivity and Specificity of CA 19-9 for Pancreatic Carcinoma in Comparison to Chronic Pancreatitis. Serological and Immunohistochemical Findings

Cited by 67 publications

References 0 publications

Diagnosing and Staging of Pancreatic Carcinoma – What Is Necessary?

Diagnosing and Staging of Pancreatic Carcinoma – What Is Necessary?

Serum CA 19-9 as a Biomarker for Pancreatic Cancer—A Comprehensive Review

The importance of CA 19-9 in diagnosis and monitoring of Hepatobiliary and Gastrointestinal malignancies

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