High sensitivity and automatic chemiluminescence detection of glucose and lactate using a spin-disc paper-based device

Tong, Wenqiang; Shi, Jiaming; Yu, Zhihang; Ran, Bin; Chen, Huaying; Zhu, Yonggang

doi:10.1039/d3lc00937h

Lab Chip

2024

DOI: 10.1039/d3lc00937h

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High sensitivity and automatic chemiluminescence detection of glucose and lactate using a spin-disc paper-based device

Wenqiang Tong,

Jiaming Shi,

Zhihang Yu

et al.

Abstract: This paper reports a spin-disc paper-based device with 10 individual detection units containing electromagnetic modules controlling the sample incubation time before chemiluminescence (CL) signal detection.

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Cited by 3 publications

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Self-assembly of DNA-Tb(Ⅲ) nanoparticles for label-free lactate aptasensing

Yi,

Liu,

Wang

2024

Microchemical Journal

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Self-assembly of DNA-Tb(Ⅲ) nanoparticles for label-free lactate aptasensing

Yi,

Liu,

Wang

2024

Microchemical Journal

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Dual-mode detection of glucose based on pistol-like DNAzyme-mediated exonuclease-assisted signal cycle

Lu,

Wang

2024

BioTechniques

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A tempo-spatial controllable microfluidic shear-stress generator for in-vitro mimicking of the thrombus

Yu,

Chen,

et al. 2024

J Nanobiotechnol

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Pathological conditions linked to shear stress have been identified in hematological diseases, cardiovascular diseases, and cancer. These conditions often exhibit significantly elevated shear stress levels, surpassing 1000 dyn/cm2 in severely stenotic arteries. Heightened shear stress can induce mechanical harm to endothelial cells, potentially leading to bleeding and fatal consequences. However, current technology still grapples with limitations, including inadequate flexibility in simulating bodily shear stress environments, limited range of shear stress generation, and spatial and temporal adaptability. Consequently, a comprehensive understanding of the mechanisms underlying the impact of shear stress on physiological and pathological conditions, like thrombosis, remains inadequate. To address these limitations, this study presents a microfluidic-based shear stress generation chip as a proposed solution. The chip achieves a substantial 929-fold variation in shear stress solely by adjusting the degree of constriction in branch channels after PDMS fabrication. Experiments demonstrated that a rapid increase in shear stress up to 1000 dyn/cm2 significantly detached 88.2% cells from the substrate. Long-term exposure (24 h) to shear stress levels below 8.3 dyn/cm2 did not significantly impact cell growth. Furthermore, cells exposed to shear stress levels equal to or greater than 8.3 dyn/cm2 exhibited significant alterations in aspect ratio and orientation, following a normal distribution. This microfluidic chip provides a reliable tool for investigating cellular responses to the wide-ranging shear stress existing in both physiological and pathological flow conditions. Graphical Abstract

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High sensitivity and automatic chemiluminescence detection of glucose and lactate using a spin-disc paper-based device

Abstract: This paper reports a spin-disc paper-based device with 10 individual detection units containing electromagnetic modules controlling the sample incubation time before chemiluminescence (CL) signal detection.

Cited by 3 publications

References 46 publications

Self-assembly of DNA-Tb(Ⅲ) nanoparticles for label-free lactate aptasensing

Self-assembly of DNA-Tb(Ⅲ) nanoparticles for label-free lactate aptasensing

Dual-mode detection of glucose based on pistol-like DNAzyme-mediated exonuclease-assisted signal cycle

A tempo-spatial controllable microfluidic shear-stress generator for in-vitro mimicking of the thrombus

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