High-Sensitive Smartphone-Based Raman System Based on Cloud Network Architecture

Mu, Taotao; Li, Su; Feng, Huanhuan; Zhang, Chengchen; Wang, Bing; Ma, Xing; Guo, Jinhong; Huang, Boji; Zhu, Lianqing

doi:10.1109/jstqe.2018.2832661

Cited by 31 publications

(25 citation statements)

References 22 publications

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“…For instance, SERS sensors can be incorporated into the monitoring system of smart toilets for health assessment. Recently, a smartphone system was proposed with Raman spectrometer integrated into the phone backside [ 134 ]. The wireless communication function of the smartphone could be used to connect with the cloud server for spectral analysis.…”

Section: Discussionmentioning

confidence: 99%

Human metabolite detection by surface-enhanced Raman spectroscopy

Liu

2022

Materials Today Bio

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Metabolites are important biomarkers in human body fluids, conveying direct information of cellular activities and physical conditions. Metabolite detection has long been a research hotspot in the field of biology and medicine. Surface-enhanced Raman spectroscopy (SERS), based on the molecular “fingerprint” of Raman spectrum and the enormous signal enhancement (down to a single-molecule level) by plasmonic nanomaterials, has proven to be a novel and powerful tool for metabolite detection. SERS provides favorable properties such as ultra-sensitive, label-free, rapid, specific, and non-destructive detection processes. In this review, we summarized the progress in recent 10 years on SERS-based sensing of endogenous metabolites at the cellular level, in tissues, and in biofluids, as well as drug metabolites in biofluids. We made detailed discussions on the challenges and optimization methods of SERS technique in metabolite detection. The combination of SERS with modern biomedical technology were also anticipated.

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Section: Discussionmentioning

confidence: 99%

Human metabolite detection by surface-enhanced Raman spectroscopy

Liu

2022

Materials Today Bio

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“…12) could provide resource-aware e-health frameworks for data sharing and diagnostically relevant information extraction, which allows medical specialists to improve service productivity and reduce computational complexity so as to decrease the cost for leukocyte counting. Both technologies are beneficial for the development of user-friendly point-of-care testing and have good prospects [117][118][119][120]. These key issues have led to the transformation of WBC detection from precision and high technology to low-cost and intelligent research.…”

Section: Discussionmentioning

confidence: 99%

White blood cell counting at point‐of‐care testing: A review

Luo

Chen

2020

Electrophoresis

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White blood cells, which are also called leukocytes, are found in the immune system that are involved in protecting the body against infections and foreign invaders. Conventional methods of leukocyte analysis provide valuable and accurate information to medical specialists. Analyzing and diagnosing of a disease requires a combination of multiple biomarkers, in some cases, however, such as personal health care, this will occupy some medical resources and causes unnecessary consumption. Traditional method (such as flow cytometer) for WBC counting is time and labor consuming. Compared to gold standard (flow‐based fraction/micropore filtration) or improved filtration methods for WBC counting, this is still a lengthy and time consuming process and can lead to membrane fouling due to the rapid accumulation of biological materials. Therefore, the analysis of WBC counts requires more compact and efficient equipment. The microfluidic technologies, powered by different field (force, thermal, acoustic, optical, magnetic) and other methods for leukocyte counting and analysis, are much cost‐efficient and can be used in in‐home or in resource‐limited areas to achieve Point‐of‐Care (POC). In this review, we highlight the mainstream devices that have been commercialized and extensively employed for patients for WBC counting, Next, we present some recent development with regards to leucocyte counting (mainly microfluidic technologies) and comment on their relative merits. We aim to focus and discuss the possibility of achieving POC and help researchers to tackle individual challenges accordingly. Finally, we offer some technologies in addition to previous detection devices, such as image recognition technology and cloud computing, which we believe have great potential to further promote real‐time detection and improve medical diagnosis.

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“…This technology, as a dielectrophoresis‐assisted clinical diagnosis, is featured by a front sensor to collect the relevant biomedical data to help the doctor analyze the patient's condition and make diagnostic decisions. Precise analysis of these data is critical to improve the reliability of diagnostic methods .…”

Section: Cell Manipulation Approaches By Dielectrophoresismentioning

confidence: 99%

Microfluidic device embedding electrodes for dielectrophoretic manipulation of cells‐A review

et al. 2018

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Microfluidic device embedding electrodes realizes cell manipulation with the help of dielectrophoresis. Cell manipulation is an important technology for cell sorting and cell population purification. Till now, the theory of dielectrophoresis has been greatly developed. Microfluidic devices with various arrangements of electrodes have been reported from the beginning of the single non‐uniform electric field to the later multiple physical fields. This paper reviews the research status of microfluidic device embedding electrodes for cell manipulation based on dielectrophoresis. Firstly, the working principle of dielectrophoresis is explained. Next, cell manipulation approaches based on dielectrophoresis are introduced. Then, different types of electrode arrangements in the microfluidic device for cell manipulation are discussed, including planar, multilayered and microarray dot electrodes. Finally, the future development trend of the dielectrophoresis with the help of microfluidic devices is prospected. With the rapid development of microfluidic technology, in the near future, high precision, high throughput, high efficiency, multifunctional, portable, economical and practical microfluidic dielectrophoresis will be widely used in the fields of biology, medicine, agriculture and so on.

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High-Sensitive Smartphone-Based Raman System Based on Cloud Network Architecture

Cited by 31 publications

References 22 publications

Human metabolite detection by surface-enhanced Raman spectroscopy

Human metabolite detection by surface-enhanced Raman spectroscopy

White blood cell counting at point‐of‐care testing: A review

Microfluidic device embedding electrodes for dielectrophoretic manipulation of cells‐A review

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