High Seminal Platelet‐Activating Factor Acetylhydrolase Activity in Men With Spinal Cord Injury

Zhu, Jiuming; Brackett, Nancy L.; Aballa, Teodoro C.; Lynne, Charles M.; Witt, Michael A.; Kort, Hilton I.; Roudebush, William E.

doi:10.2164/jandrol.05159

Cited by 20 publications

(6 citation statements)

References 51 publications

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“…The latter substance has been found to have a significantly higher activity in the seminal plasma of SCI men than in healthy men. The enzymatic activity of PAFah is negatively correlated with sperm motility (Ricker et al, 1989;Zhu et al, 2006). This is because PAFah catalyses hydrolysis of esterified PAF at the sn-2 position producing acetate and biologically inactive lyso-PAF.…”

Section: Seminal Plasma Biochemistry and Scimentioning

confidence: 99%

Erectile function and male reproduction in men with spinal cord injury: a review

et al. 2010

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Spinal cord injury (SCI) in men results in defects in erectile function, ejaculatory process and male reproductive potential. There are alterations in the capacity of men with SCI to achieve reflexogenic, psychogenic and nocturnal erections. The sexual function in different stages after SCI and the types of erections depend mainly on the completeness of the injury and the level of neurological damage. Furthermore, most of the SCI men demonstrate defects concerning the entrance of semen into the posterior urethra and the expulsion of the semen through the penile urethra and the urethral orifice. In addition, SCI men develop defects in the secretory function of the Leydig cells, Sertoli cells and the male accessory genital glands. The overall result is a decreased quality of the semen is recovered either with penile vibratory stimulation (PVS) or with electroejaculation. Nowadays the therapeutic andrological approach of SCI men focuses on achievement of erectile function, recovery of spermatozoa and assisted reproductive technology. The first line of therapy recommended for infertility in SCI men is collection of semen via PVS with concomitant evaluation of total motile sperm yields for assisted conception which may include intravaginal insemination, intrauterine insemination, or in vitro fertilisation/intracytoplasmic sperm injection. Patients failing PVS may be referred for electroejaculation or surgical sperm retrieval.

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Section: Seminal Plasma Biochemistry and Scimentioning

confidence: 99%

Erectile function and male reproduction in men with spinal cord injury: a review

et al. 2010

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“…Platelet-activating factor is an important phospholipid mediator stimulating motility, capacitation, and fertiliza-tion activities of the sperm. Seminal plasma plateletactivating factor acetylhydrolase activity results in depleted platelet-activating factor levels and has been found to be higher in men with SCI with an associated correlation to decreased sperm motility (64). An additional possible causal factor underlying asthenozoospermia is an association between antisperm antibodies and semen from men with SCI.…”

Section: Seminal Fluid and Changesmentioning

confidence: 99%

Effects of Spinal Cord Injury on Semen Parameters

Patki

Woodhouse²,

Hamid³

et al. 2008

The Journal of Spinal Cord Medicine

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Objective/Background: Neurogenic reproductive dysfunction in men with spinal cord injury (SCI) is common and the result of a combination of impotence, ejaculatory failure, and abnormal semen characteristics. It is well established that the semen quality of men with SCI is poor and that changes are seen as early as 2 weeks after injury. The distinguishing characters of poor quality are abnormal sperm motility and viability. In the majority of the men with SCI, the sperm count is not abnormal. We elaborate on the effects of the SCI on semen parameters that may contribute to poor motility and poor viability. Methods: Review. Design: PubMed and MEDLINE databases were searched using the following key words: spinal cord injuries, fertility, sexual dysfunction, and spermatogenesis. All literature was reviewed by the team of authors according to the various stages of sperm development and transport in the male reproductive cycle. Findings: The cause of asthenozoospermia appears to be multifactorial. Conclusion: Current literature does not support the preeminence of a single factor relating to neurogenic reproductive dysfunction in men with SCI. After SCI, there is ample evidence of disturbance of sperm production, maturation and storage, and transport due to an abnormal neuroendocrine milieu. Semen quality seems to be primarily affected by changes to the seminal plasma constituents, type of bladder management, and the neurogenic impairment to the ejaculatory function. Further focused and structured studies are required.

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“…PAF-AH level has significant negative correlation with sperm motility in panda seminal plasma and has negative correlation with the state of sperm movement too [18]. The concentration of PAF-AH in seminal plasma of male patient, whose spinal column was injured, is prominently higher than normal people; meanwhile, it has negative correlation to sperm motility [19]. In a study investigating the relation between PAF-AH level and sperm vigor, the researchers found that when sperm motility was equal to or above 50%, PAF-AH density was 442.03 ± 14.37 IU/L, while when the vigor is below 50%, the PAF-AH density is 882.16 ± 18.45 IU/L [20].…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance and Expression of PAF and TNF-alpha in Seminal Plasma of Leukocytospermic Patients

Liu

Liu²,

Wang³

et al. 2012

Mediators of Inflammation

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Objective. Discuss the changes and roles of PAF in the reproductive tract infection by observing the expression of platelet activating factor (PAF) and tumor necrosis factor α (TNF-α) in seminal plasma of patients with leukocytospermia. Methods. The seminal plasma was obtained from 22 cases of leukocytospermia and 15 cases of normal males; the peroxidase dyeing method was adopted for seminal plasma white blood count; the ELISA was adopted to test PAF and TNF-α concentration in seminal plasma. Result. PAF concentration (2.14 ± 0.43 ng/mL) of leukocytospermia group was significantly lower than the normal group (6.21 ± 1.38 ng/mL, P < 0.01) while TNF-α (5.51 ± 1.46 ng/mL) was significantly higher than that of normal group (3.48 ± 1.08 ng/mL). There was negative correlation between PAF and TNF-α , (r = −0.68, P < 0.01); the same situation existed in PAF and WBC (r = −0.62, P < 0.01); but TNF-α was positively correlated to WBC (r = 0.77, P < 0.01). Conclusion. (1) Low expression of PAF and high expression of TNF-α in leukocytospermia affect the sperm motility, which is one of the reasons that leads to infertility. (2) Lower expression of PAF has its particularity during the reproductive tract infection.

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High Seminal Platelet‐Activating Factor Acetylhydrolase Activity in Men With Spinal Cord Injury

Cited by 20 publications

References 51 publications

Erectile function and male reproduction in men with spinal cord injury: a review

Erectile function and male reproduction in men with spinal cord injury: a review

Effects of Spinal Cord Injury on Semen Parameters

Clinical Significance and Expression of PAF and TNF-alpha in Seminal Plasma of Leukocytospermic Patients

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