“…In our review, half of the studies were conducted in the United States with a population of 2915 patients 11,[15][16][17][18]20,25,28,31,32,34,35 compared with 747 patients from studies performed in either Europe, Asia, or South America. 10,19,[21][22][23][24]26,27,29,30,33,36 The average age of transfeminine was older in the United States when compared with the rest of the world at 40.48 years and 32.41 years, respectively. In contrast, the average age of transmasculine patients was younger in the United States when compared with the rest of the world at 21.57 and 29.58 years, respectively, although neither comparison was statistically significant.…”