High Selenium Yeast mitigates aluminum-induced cerebral inflammation by increasing oxidative stress and blocking NO production

Abstract

High Selenium Yeast (SeY) serves many important roles with respect to the maintenance of normal nervous system functioning. Studies have reported the nerve inflammation induced by Aluminum (Al) was associated with the increase of mortality. However, in-depth studies are required to verify the hypothesized neuro-protective efficacy of SeY against Al-induced cerebral damage through modulation of the inflammatory response. Here, mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 28 days. Inflammation was assessed by histopathological examination and expression of biomarkers for inflammation. Furthermore, the oxidation-reduction levels and the NO production were assessed using diagnostic kits and RT-PCR. The data indicated that SeY significantly protected cerebrum against Al-induced pathological changes, in addition to the disordered expression of biomarkers of inflammation, the imbalance of oxidation-reduction, and the increase of NO production. Therefore, the chemoprotective potential of SeY against Al-induced cerebral inflammation via restore the levels of oxidation-reduction and the generation of NO was demonstrated.

Neuroprotective Efficiency of Prodigiosins Conjugated with Selenium Nanoparticles in Rats Exposed to Chronic Unpredictable Mild Stress is Mediated Through Antioxidative, Anti-Inflammatory, Anti-Apoptotic, and Neuromodulatory Activities

“… 58 Previous investigations examining Se or SeNPs have indicated their abilities to improve the activities and expression of endogenous antioxidant proteins and suppress ROS production following neuronal damage. 66 , 75 , 76 Chitosan-stabilized Se nanoparticles also displayed more antioxidant power toward acrylamide-induced neural damage, as demonstrated by reduced cerebral MDA and NO levels and increased GSH levels. 77 The antioxidant potential of PDGs may also be associated with free radical-scavenging properties and the ability to interfere with NOS activity to suppress NO production.…”

<p>Selenium Nanoparticles Pre-Treatment Reverse Behavioral, Oxidative Damage, Neuronal Loss and Neurochemical Alterations in Pentylenetetrazole-Induced Epileptic Seizures in Mice</p>

“…It has been demonstrated that the epileptic mice treated with selenium showed a decrease in NO generation due to the inhibition of NOS. Cao et al 59 reported that dietary administration of selenium reversed the increased NO in the cerebral tissue following aluminum exposure. The authors attributed this reduction to the ability of selenium to down-regulate NOS.…”

Effects of Methyl Sulfonyl Methane and Selenium Yeast on Fatty Liver Syndrome in Laying Hens and Their Biological Mechanisms

“…Adding selenium to feed can also effectively reduce the damage caused by inflammation. For example, in mice, Se-Y can inhibit neuroinflammation caused by inorganic aluminum, including the disorder of inflammatory factor expression and the imbalance of the redox system [13]. In addition, selenium is also a commonly used antioxidant in poultry breeding and is mainly used to improve the production performance of poultry and for the production of selenium-rich eggs [7,14].…”