High selenium levels associate with reduced risk of mortality and new‐onset heart failure: data from <scp>PREVEND</scp>

Al‐Mubarak, Ali A.; Beverborg, Niels Grote; Suthahar, Navin; Gansevoort, Ron T.; Bakker, Stephan J. L.; Touw, Daan; Boer, Rudolf A. de; Meer, Peter van der

doi:10.1002/ejhf.2405

Cited by 26 publications

(25 citation statements)

References 32 publications

(107 reference statements)

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“…Patients with Keshan disease develop dilated cardiomyopathy and heart failure. High serum levels of selenium have also been independently associated with both reduced mortality and fewer cases of new-onset heart failure in a population-based cohort study 134 . Therefore, well-powered interventional studies designed to further evaluate the potential benefits of high selenium levels in humans are warranted.…”

Section: Molecular and Metabolic Drivers Of Ferroptosismentioning

confidence: 97%

The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease

et al. 2022

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The maintenance of iron homeostasis is essential for proper cardiac function. A growing body of evidence suggests that iron imbalance is the common denominator in many subtypes of cardiovascular disease. In the past 10 years, ferroptosis, an iron-dependent form of regulated cell death, has become increasingly recognized as an important process that mediates the pathogenesis and progression of numerous cardiovascular diseases, including atherosclerosis, drug-induced heart failure, myocardial ischaemia–reperfusion injury, sepsis-induced cardiomyopathy, arrhythmia and diabetic cardiomyopathy. Therefore, a thorough understanding of the mechanisms involved in the regulation of iron metabolism and ferroptosis in cardiomyocytes might lead to improvements in disease management. In this Review, we summarize the relationship between the metabolic and molecular pathways of iron signalling and ferroptosis in the context of cardiovascular disease. We also discuss the potential targets of ferroptosis in the treatment of cardiovascular disease and describe the current limitations and future directions of these novel treatment targets.

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Section: Molecular and Metabolic Drivers Of Ferroptosismentioning

confidence: 97%

The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease

et al. 2022

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“…Higher levels of selenium were independently associated with a lower risk of death and new‐onset HF. A significant interaction was found between smoking status and the impact of selenium levels on clinical events 9 …”

Section: Pathophysiologymentioning

confidence: 94%

February 2022 at a glance: focus on pathophysiology and acute heart failure

Tomasoni

Adamo

Metra

2022

European J of Heart Fail

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This issue includes a two-part position statement from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) about the pathophysiology of Takotsubo syndrome. It provides an overview on the role of catecholamines and sympathetic nervous system and a throughout discussion on vascular pathophysiology and gender differences. 1,2 Physical exercise and nutritionExercise capacity is impaired in patients with heart failure (HF) with a major impact on their poorer quality of life and frequent hospitalizations. [3][4][5] Nijholt et al. 6 reviewed the most recent findings in the field, focusing on newly discovered pathways associated with muscular growth, mechanisms of exercise intolerance and potential therapeutic options.The role of nutritional status in HF patients is well-established. 7,8 Malnutrition refers also to specific micronutrient deficiencies (i.e. selenium). The levels of selenium were measured in a cohort of 5973 Dutch subjects. Higher levels of selenium were independently associated with a lower risk of death and new-onset HF. A significant interaction was found between smoking status and the impact of selenium levels on clinical events. 9

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“…Moreover, Se levels were also associated with the incidence of new-onset heart failure, anemia, iron deficiency, high C-reactive protein (CRP) levels, and current smoking [ 74 ]. Recently, it was reported that serum Se is related to multiple indicators of metabolic syndrome, including high levels of blood glucose, cholesterol, and body mass index (BMI) in the general adult population [ 74 ]. For instance, a cross-sectional analysis of 4,339 participants found that Se levels were positively associated with IR and blood glucose; that is, a 10 μ g/L increase in Se was associated with a 1.5% increase in insulin [ 15 ].…”

Section: Se Levels and Metabolic Diseasesmentioning

confidence: 99%

Section: Se Levels and Metabolic Diseasesmentioning

confidence: 99%

“…Prospective studies have found that a high Se status is associated with decreased mortality, wherein low plasma Se was related to increased overall and cancer mortality [74][75][76]. Moreover, Se levels were also associated with the incidence of new-onset heart failure, anemia, iron deficiency, high Creactive protein (CRP) levels, and current smoking [74]. Recently, it was reported that serum Se is related to multiple indicators of metabolic syndrome, including high levels of blood glucose, cholesterol, and body mass index (BMI) in the general adult population [74].…”

Section: Se Levels and Metabolic Diseasesmentioning

confidence: 99%

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Selenium Status and Its Antioxidant Role in Metabolic Diseases

Huang

Xie

Song

et al. 2022

Oxidative Medicine and Cellular Longevity

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Selenium (Se), in the form of selenoproteins, is an essential micronutrient that plays an important role in human health and disease. To date, there are at least 25 selenoproteins in humans involved in a wide variety of biological functions, including mammalian development, metabolic progress, inflammation response, chemoprotective properties, and most notably, oxidoreductase functions. In recent years, numerous studies have reported that low Se levels are associated with increased risk, poor outcome, and mortality of metabolic disorders, mainly related to the limited antioxidant defense resulting from Se deficiency. Moreover, the correlation between Se deficiency and Keshan disease has received considerable attention. Therefore, Se supplementation as a therapeutic strategy for preventing the occurrence, delaying the progression, and alleviating the outcomes of some diseases has been widely studied. However, supranutritional levels of serum Se may have adverse effects, including Se poisoning. This review evaluates the correlation between Se status and human health, with particular emphasis on the antioxidant benefits of Se in metabolic disorders, shedding light on clinical treatment.

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High selenium levels associate with reduced risk of mortality and new‐onset heart failure: data from PREVEND

Abstract: To elucidate the relationship between serum selenium levels and the risk of mortality and new-onset heart failure (HF) in the general adult population.

Cited by 26 publications

References 32 publications

The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease

The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease

February 2022 at a glance: focus on pathophysiology and acute heart failure

Selenium Status and Its Antioxidant Role in Metabolic Diseases

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