High selenium exposure lowers the odds ratios for hypertension, stroke, and myocardial infarction associated with mercury exposure among Inuit in Canada

Hu, Xue; Eccles, Kristin M.; Chan, Hing Man

doi:10.1016/j.envint.2017.03.002

Cited by 63 publications

(34 citation statements)

References 57 publications

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“…2012b , 2012a ) were exposed to moderate to high level of Hg. The coastal and Indigenous population consists of Inuit living in the Arctic ( Hu et al. 2017 ; Nielsen et al.…”

Section: Resultsmentioning

confidence: 99%

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Mercury Exposure, Blood Pressure, and Hypertension: A Systematic Review and Dose–response Meta-analysis

Singh

Chan

2018

Environ Health Perspect

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113

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Background:Body burden of mercury has been linked to hypertension in populations exposed to high mercury levels.Objectives:We summarized, extracted, and pooled the results of published studies that investigated mercury biomarkers and hypertension or blood pressure (BP) measurements to examine this potential relationship.Methods:We searched PubMed, Embase, and TOXLINE and selected studies according to a priori defined inclusion criteria. Study quality was assessed by the Newcastle-Ottawa scale for cohort and case–control studies and the Quality Assessment Tool for cross-sectional studies. Study estimates were pooled using inverse-variance weighted random-effects models. Dose–response meta-analysis was performed with studies reporting hypertension and systolic BP for at least three mercury categories.Results:A total of 29 studies were included in the meta-analysis. The pooled odds ratio (OR) for hypertension, comparing the highest and lowest mercury exposure categories, was 1.35 [95% confidence interval (CI): 0.99, 1.83] for populations with hair mercury ≥2μg/g in comparison with the OR of 1.12 (95% CI: 0.82, 1.52) for populations with hair mercury <2μg/g. Positive associations were also observed for highest versus lowest mercury exposure categories on systolic and diastolic BP. Heterogeneity was observed for mercury species and exposure groups across different studies. Associations estimated using different mercury biomarkers generally agree with each other in the same study. A nonlinear dose–response relationship with an inflection point at 3μg/g was identified, for both hypertension and systolic BP.Conclusions:A significant positive association between mercury and hypertension and between mercury and BP was identified. The exposure dose is an important factor in determining the toxic effects of mercury on hypertension. https://doi.org/10.1289/EHP2863

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“…2012b , 2012a ) were exposed to moderate to high level of Hg. The coastal and Indigenous population consists of Inuit living in the Arctic ( Hu et al. 2017 ; Nielsen et al.…”

Section: Resultsmentioning

confidence: 99%

“…The estimates from nonfish consumers were extracted for the pooling of effect size estimates. In Example 2, OR of hypertension in the highest exposure category is smaller than that in the second highest exposure category ( Hu et al. 2017 ; Mozaffarian et al.…”

Section: Discussionmentioning

confidence: 98%

Mercury Exposure, Blood Pressure, and Hypertension: A Systematic Review and Dose–response Meta-analysis

Singh

Chan

2018

Environ Health Perspect

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113

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“…Nutrients and other contaminants can have substantial ameliorative or exacerbating influences on Hg toxicity, complicating estimates of the health risks associated with Hg exposure (Rice 2008 ). Although there are potentially limitless combinations of coexposure mixtures that may influence health outcomes associated with Hg exposure, the most common include selenium (Se; (Cuvin-Aralar and Furness 1991 ; Hu et al 2017 ), other biomagnifying contaminants such as polychlorinated biphenyls (PCBs) and other halogenated organic compounds (Braune et al 2005 ; Burgess et al 2005 ), co-occurring contaminants in point-source situations such as lead and arsenic in mining areas (Basu et al 2011 , 2015a ), and dietary nutrients like omega-3 fatty acids (Gribble et al 2016 ). Of these, Se is arguably the most compelling because of the extreme complexity and magnitude of its antagonistic interaction with Hg, which has evoked the greatest discussion and debate with no clear consensus.…”

Section: Domain 3: Interacting Extrinsic and Intrinsic Drivers That Imentioning

confidence: 99%

Modulators of mercury risk to wildlife and humans in the context of rapid global change

Eagles‐Smith

Silbergeld

Basu

et al. 2018

Ambio

282

163

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Environmental mercury (Hg) contamination is an urgent global health threat. The complexity of Hg in the environment can hinder accurate determination of ecological and human health risks, particularly within the context of the rapid global changes that are altering many ecological processes, socioeconomic patterns, and other factors like infectious disease incidence, which can affect Hg exposures and health outcomes. However, the success of global Hg-reduction efforts depends on accurate assessments of their effectiveness in reducing health risks. In this paper, we examine the role that key extrinsic and intrinsic drivers play on several aspects of Hg risk to humans and organisms in the environment. We do so within three key domains of ecological and human health risk. First, we examine how extrinsic global change drivers influence pathways of Hg bioaccumulation and biomagnification through food webs. Next, we describe how extrinsic socioeconomic drivers at a global scale, and intrinsic individual-level drivers, influence human Hg exposure. Finally, we address how the adverse health effects of Hg in humans and wildlife are modulated by a range of extrinsic and intrinsic drivers within the context of rapid global change. Incorporating components of these three domains into research and monitoring will facilitate a more holistic understanding of how ecological and societal drivers interact to influence Hg health risks.

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“…In a study of 852 Inuit adults who participated in the 2004 Nunavik Inuit Health Survey, up to 50% of plasma mercury was associated with SELENOP [32]. In the International Polar Year Inuit Health Survey (IHS) of Inuit in Canada conducted in 2007 and 2008, geometric mean blood Se and total Hg were 319.5 μg/L and 7.0 μg/L, respectively [33]. High Se exposure was shown to lower the odds ratios for hypertension, stroke, and myocardial infarction associated with mercury exposure [33].…”

Section: Adverse Health Effects Associated With or Caused By Both Smentioning

confidence: 99%

“…In the International Polar Year Inuit Health Survey (IHS) of Inuit in Canada conducted in 2007 and 2008, geometric mean blood Se and total Hg were 319.5 μg/L and 7.0 μg/L, respectively [33]. High Se exposure was shown to lower the odds ratios for hypertension, stroke, and myocardial infarction associated with mercury exposure [33]. In the same study, participants with stroke had lower blood Se (geometric mean: 260 μg/L vs. 319 μg/L) and dietary Se (144 μg/day vs. 190 μg/day) than individuals without stroke [34].…”

Section: Adverse Health Effects Associated With or Caused By Both Smentioning

confidence: 99%

Selenium intake, status, and health: a complex relationship

2019

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Both selenium (Se) deficiency and excess are found in natural locations throughout the world, though Se excess can also be caused by supplementation with Se. Both have been associated with adverse health effects that have often been characterized by a U-shaped relationship. Some health effects, such as increased mortality, are associated with both low and high Se status. Certain people and populations are better able to tolerate low or high Se intake than others; there are a number of possible explanations for this fact. Firstly, it may relate to the presence of polymorphisms (SNPs) in genes that improve the ability to deal with a low or high Se intake. Secondly, high Se status, with apparent absence of toxicity and even beneficial effects, can be found in populations exposed to toxic elements that are known to interact with Se, forming complexes in some cases. Thirdly, beneficial and harmful effects of Se depend on Se dose and form (speciation); for instance, at a high dose, selenomethionine (SeMet) has toxic effects that are mediated by metabolism to selenols/selenolates that can redox-cycle, generate superoxide radicals and react with thiols/diselenides to produce selenyl sulphides/disulphides. Finally, it is possible that exposure to a high Se intake from birth or from a very young age may alter the composition of the gut microbiota in such a way that excess Se is more readily excreted, thus reducing its toxicity.

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High selenium exposure lowers the odds ratios for hypertension, stroke, and myocardial infarction associated with mercury exposure among Inuit in Canada

Cited by 63 publications

References 57 publications

Mercury Exposure, Blood Pressure, and Hypertension: A Systematic Review and Dose–response Meta-analysis

Mercury Exposure, Blood Pressure, and Hypertension: A Systematic Review and Dose–response Meta-analysis

Modulators of mercury risk to wildlife and humans in the context of rapid global change

Selenium intake, status, and health: a complex relationship

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