High-Scatter Lymphocytes in the Blood of Erythrodermic Cutaneous T-Cell Lymphoma: Evidence for Large-Cell Transformation?

Large-cell transformation is an independent poor prognostic factor in Sézary syndrome: analysis of 117 cases

“…Although widely used since, the reliability of these criteria has never been specifically studied in SS. Additionally, the presence of large circulating Sézary cells (SCs) based on cytomorphological and flow cytometry analysis was independently associated with poor outcome and might predict LCT occurrence in skin 5,6 . Nevertheless, the prognostic impact of structure parameters [forward scatter (FSC) and side scatter (SSC)] of circulating cells in cytometry and correlation with LCT remains to be determined in SS.…”